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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00752


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00752
General rule information [?]

Accession PRU00752
Dates 11-FEB-2025 (Created)
11-FEB-2025 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51418; RAN
Name Small GTPase Ran-type domain
Function GTP-binding proteins involved in nucleocytoplasmic transport. Required for the import of proteins into the nucleus and also for RNA export.
Scope(s) Eukaryota
Example(s) P38545;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the small GTPase superfamily. Ran family.

Keywords [?]

GTP-binding
Nucleotide-binding
Nucleus
Protein transport
Transport

Gene Ontology [?]

GO:0003924; Molecular function:GTPase activity
GO:0005525; Molecular function:GTP binding
GO:0005634; Cellular component:nucleus
GO:0006606; Biological process:protein import into nucleus
GO:0000054; Biological process:ribosomal subunit export from nucleus
GO:0005737; Cellular component:cytoplasm

Features [?]

From: PS51418
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Small GTPase Ran-type #"
REGION 31 39 /note="Switch-I #"
REGION 62 78 /note="Switch-II #"

Additional information [?]

Size range 162-182 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]