PROSITE entry PS51418

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51418
Entry name [info]	RAN
Accession [info]	PS51418
Entry type [info]	MATRIX
Date [info]	01-DEC-2008 CREATED; 18-JUN-2025 DATA UPDATE; 18-JUN-2025 INFO UPDATE.
PROSITE Doc. [info]	PDOC51417
Associated ProRule [info]	PRU00752

Name and characterization of the entry

Description [info]

Small GTPase Ran-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=165;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=160;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.6267861; R2=0.0053948; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=3639; N_SCORE=19.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1322; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-6; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P';  M=  7,  6,-31,  7,  9,-35,  2,  0, -6,  0,-14, -7,  5, 18,  6, -3,  5,  5, -3,-62,-39,  6;
/M: SY='V';  M= -2, -1,-30, -4, -1,-11, -9, -4,  6, -3,  2,  4, -1, -7, -2, -4, -4, -2,  7,-48,-14, -2;
/M: SY='P';  M=  7,  2,-21,  0,  2,-27,  2, -8,  2, -8, -9, -4, -3, 21, -2, -9,  6,  8,  4,-59,-35, -2;
/M: SY='A';  M=  5,  1,-25,  1,  0,-22,  0, -3,  3, -1, -6,  1,  1,  3,  2,  0,  3,  5,  3,-44,-26,  0;
/M: SY='F';  M=-29,-39,-39,-49,-49,107,-49,-20, 20,-49, 30, 10,-29,-39,-39,-39,-29,-29,  1, 18, 96,-49;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 11,-20, 39,-20,  0, 10,  0, 11, 39,  0,  0,-20,-31,-40, 10;
/M: SY='L';  M=-20,-30,-51,-31,-31, 27,-30,-20, 28,-21, 65, 36,-30,-20,-21,-30,-19,-10, 28,-22,  0,-21;
/M: SY='V';  M=  0,-12,-20,-20,-12,  4,-12,-20, 32,-20, 30, 20,-10,-10,-12,-20,-10,  0, 38,-58,-16,-12;
/M: SY='L';  M=-18,-29,-57,-29,-29, 29,-29,-20, 31,-20, 67, 38,-28,-19,-20,-29,-19, -9, 30,-22,  0,-20;
/M: SY='V';  M=  0,-13,-19,-20,-13,  5,-13,-20, 33,-20, 29, 20,-10,-10,-13,-20,-10,  0, 37,-57,-14,-13;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='G';  M=  7,  5, -7,  4,  3,-48, 31,-12,-20,-14,-33,-23,  6, -2, -5,-21,  9,  7,-11,-69,-43, -5;
/M: SY='A';  M=  9, -1,-20, -2, -1,-26,  8,-11,  4, -2, -5,  2, -1,  8, -1, -2,  8,  9,  5,-51,-29, -1;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 10,-20, 40,-20,  0, 10,  0, 10, 40,  0,  0,-20,-30,-40, 10;
/M: SY='A';  M= 10,  0,-20,  0,  0,-30, 10,-10,  0,  0,-10,  0,  0, 10,  0,  0, 10, 10,  0,-50,-30,  0;
/M: SY='A';  M= 10,  1,-20,  1,  1,-30, 10,-10,  0, -1,-11, -1,  0, 10,  0, -1, 10, 10,  0,-51,-30,  0;
/M: SY='F';  M=-28,-38,-44,-46,-46, 96,-46,-20, 22,-45, 37, 15,-30,-36,-36,-38,-28,-26,  5, 13, 82,-45;
/M: SY='V';  M=  0,-11,-20,-20,-11,  2,-11,-20, 31,-20, 30, 20,-10,-10,-11,-20,-10,  0, 39,-59,-18,-11;
/M: SY='K';  M= -8,  9,-47,  9,  9,-48, -8,  8,-18, 36,-19,  0,  9,  1,  9, 36,  1,  1,-18,-32,-39,  9;
/M: SY='R';  M=-10,  0,-40,  0,  0,-40,-20, 20,-20, 40,-30,  0, 10,  0, 10, 50,  0,  0,-20, 30,-40, 10;
/M: SY='H';  M=-12,  5,-31,  4,  4, -6,-14, 42,-16,  4,-15, -8,  6, -4, 22, 14, -3,-12,-18,-16, 11, 12;
/M: SY='L';  M=-17,-28,-54,-28,-28, 27,-28,-20, 31,-19, 63, 38,-27,-18,-19,-28,-18, -8, 30,-25, -1,-19;
/M: SY='A';  M= 10,  0,-19,  0,  0,-30, 10,-10,  0,  0,-10,  0,  0, 10,  0,  0, 10, 10,  0,-49,-30,  0;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='D';  M=  8, 19,-50, 28, 28,-50,  8, 10,-20, 13,-29,-18, 19,  0, 19,  4,  0,  0,-11,-66,-40, 28;
/M: SY='F';  M=-30,-40,-40,-50,-50,110,-50,-20, 20,-50, 30, 10,-30,-40,-40,-40,-30,-30,  0, 20,100,-50;
/M: SY='D';  M=  6, 18,-50, 26, 26,-50,  6, 10,-20, 15,-28,-16, 18,  0, 18,  7,  0,  0,-12,-63,-40, 26;
/M: SY='K';  M=-10,  4,-50,  4,  4,-39,-12,  7,-13, 33,-10,  9,  6, -2,  6, 33, -2,  0,-13,-29,-35,  6;
/M: SY='R';  M= -7, 12,-47, 12, 12,-46, -6, 14,-19, 31,-21, -3, 10,  0, 14, 32,  1,  0,-17,-32,-39, 12;
/M: SY='Y';  M=-30,-30, 10,-40,-40,100,-50,  0,  0,-40,  0,-10,-30,-50,-40,-40,-30,-30,-20, 10,130,-40;
/M: SY='V';  M= -1, -3,-27, -7, -2,-11, -7, -8, 14, -6,  9, 10, -2, -6, -3, -5, -5,  0, 19,-46,-23, -2;
/I:         I=-13; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='P';  M= 10,  9,-19,  9,  9,-30,  9, -9, -1, -9,-19,-10,  0, 12,  0, -9, 10, 10, -1,-58,-30,  0; D=-13;
/I:         I=-13; DM=-27;
/M: SY='A';  M= 10,  0,-20,  0,  0,-30, 10,-10,  0,  0,-10,  0,  0, 10,  0,  0, 10, 10,  0,-50,-30,  0;
/M: SY='L';  M=-17,-29,-55,-29,-29, 29,-29,-20, 31,-20, 65, 37,-27,-19,-20,-29,-19, -9, 30,-24,  0,-20;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='V';  M=  0, -9,-20,-19, -9, -1, -9,-20, 29,-20, 28, 19,-10, -9,-10,-20, -9,  0, 38,-60,-20,-10;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0,  0,  0,-10,-70,-40, 30;
/M: SY='V';  M=  0,-11,-20,-20,-11,  2,-11,-20, 31,-20, 30, 20,-10,-10,-11,-20,-10,  0, 39,-59,-18,-11;
/M: SY='H';  M= -7, 12,-33, 13, 13,-25, -6, 43,-20, 10,-22,-12, 12,  0, 28, 17,  0, -8,-18,-28, -7, 21;
/M: SY='P';  M=  7,  5,-27,  5,  5,-40,  0,  8,-13,  3,-20,-10,  3, 37,  8,  3,  7,  7,-10,-57,-47,  5;
/M: SY='L';  M=-19,-29,-59,-29,-29, 29,-29,-20, 30,-20, 68, 40,-29,-19,-20,-29,-19, -9, 30,-21,  0,-20;
/M: SY='L';  M= -2, -8,-33,-12, -8, -4, -8,-14, 18,-14, 24, 15, -8, -9, -7,-18, -7, -1, 23,-49,-20, -7;
/M: SY='F';  M=-30,-40,-40,-50,-50,110,-50,-20, 20,-50, 30, 10,-30,-40,-40,-40,-30,-30,  0, 20,100,-50;
/M: SY='H';  M= -9,  7,-31,  6,  6, -8,-10, 30,-14,  2,-17, -8,  4, -6, 16,  8, -2, -9,-15,-24,  3,  9;
/M: SY='A';  M= 10,  0,-20,  0,  0,-30, 10,-10,  0,  0,-10,  0,  0, 10,  0,  0, 10, 10,  0,-50,-30,  0;
/M: SY='B';  M=  1, 18,-28, 18, 18,-30, 10,  9,-10,  9,-28, -9,  9,  1,  9,  9, 10,  1, -9,-41,-30,  9;
/M: SY='R';  M=-13, -8,-16,-10,-10,-23,-23, 10,-16, 18,-25, -5,  1, -7, -2, 27, -3, -6,-18,  8,-17, -3;
/I:         I=-8; MD=-17;
/M: SY='G';  M=  9,  9,-28,  9,  9,-47, 38, -9,-19, -9,-28,-19,  9,  0,  0,-19,  9,  9, -9,-66,-47,  0; D=-8;
/I:         I=-8; MD=-17;
/M: SY='P';  M=  5,  3,-23,  2,  2,-27,  0, -3, -1, -1, -9, -2,  1, 13,  1, -1,  4,  6,  1,-48,-32,  1; D=-8;
/I:         I=-8; MD=-17;
/M: SY='I';  M= -5,-21,-22,-24,-23, 31,-23,-19, 34,-24, 29, 18,-13,-14,-21,-22,-13, -5, 25,-37, 14,-23; D=-8;
/I:         I=-8; MD=-17;
/M: SY='R';  M= -8,  3,-32,  3,  3,-37,-13, 11,-15, 26,-21, -2,  6, -1,  7, 30, -1, -1,-15,-13,-32,  6; D=-8;
/I:         I=-8; MI=-17; MD=-17; IM=-17; DM=-17;
/M: SY='F';  M=-24,-34,-33,-42,-42, 90,-43,-18, 21,-42, 27, 10,-25,-34,-35,-35,-25,-24,  4,  8, 80,-42; D=-8;
/I:         I=-8; DM=-17;
/M: SY='D';  M=  1, 16,-31, 18, 18,-25,  5,  9,-12,  6,-26,-12, 10, -3,  9,  3,  7, -2,-13,-43,-20,  9; D=-8;
/I:         I=-8; DM=-17;
/M: SY='V';  M= -1,-11, -6,-21,-12, -3,-11,-20, 25,-21, 22, 14,-11,-10,-12,-20, -9, -1, 34,-58,-17,-12; D=-8;
/I:         I=-8; DM=-17;
/M: SY='W';  M=-57,-47,-76,-66,-66, 19,-66,-19,-47,-28,-19,-38,-38,-57,-47, 28,-28,-47,-57,246,  9,-57; D=-8;
/I:         I=-8; DM=-17;
/M: SY='D';  M=  9, 19,-47, 28, 28,-47,  9,  9,-19,  9,-28,-19, 19,  0, 19,  0,  9,  0,-19,-66,-38, 19; D=-8;
/I:         I=-8; DM=-17;
/M: SY='A';  M=  9,  0,-19,  0,  0,-28,  9, -9,  0,  0, -9,  0,  0,  9,  0,  0,  9,  9,  0,-47,-28,  0; D=-8;
/I:         I=-8; DM=-17;
/M: SY='A';  M=  9,  9,-19,  9,  9,-28,  9, -9,  0, -9,-19, -9,  0,  9,  0, -9,  9,  9,  0,-57,-28,  0; D=-8;
/I:         I=-8; DM=-17;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='H';  M= -2, 15,-51, 15, 15,-33, -3, 25,-15,  7,-11, -5,  6, -2, 25,  6, -2, -1, -6,-47,-36, 16;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0,  0,  0,-10,-70,-40, 30;
/M: SY='R';  M=-10,  8,-48,  8,  8,-48,-12, 12,-20, 40,-22,  0, 10,  0, 10, 42,  0,  0,-20,-21,-40, 10;
/M: SY='F';  M=-30,-38,-32,-48,-48,108,-50,-17, 17,-48, 25,  7,-30,-42,-40,-40,-30,-30, -3, 18,105,-48;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='L';  M=-20,-30,-60,-30,-30, 30,-30,-20, 30,-20, 70, 40,-30,-20,-20,-30,-20,-10, 30,-20,  0,-20;
/M: SY='R';  M=-10,  0,-40,  0,  0,-40,-20, 20,-20, 40,-30,  0, 10,  0, 10, 50,  0,  0,-20, 30,-40, 10;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='Y';  M=-30,-30, 10,-40,-40,100,-50,  0,  0,-40,  0,-10,-30,-50,-40,-40,-30,-30,-20, 10,130,-40;
/M: SY='Y';  M=-30,-32,  2,-42,-42,102,-50, -3,  3,-42,  5, -7,-30,-48,-40,-40,-30,-30,-17, 12,125,-42;
/M: SY='I';  M=  0,-18,-20,-20,-18, 17,-18,-20, 38,-20, 30, 20,-10,-10,-18,-20,-10,  0, 32,-52, -3,-18;
/M: SY='H';  M= -3, 14,-47, 14, 14,-31, -2, 26,-15,  7,-12, -6,  6, -2, 24,  6, -1, -2, -7,-44,-31, 15;
/M: SY='G';  M= 10, 11,-28, 12, 12,-41, 24, -8,-11, -8,-26,-16,  7,  4,  2,-14,  9,  9, -6,-66,-40,  3;
/M: SY='H';  M= -1, 18,-49, 18, 18,-40, -1, 28,-20, 13,-21, -9, 10,  0, 28, 14,  0,  0,-11,-45,-40, 19;
/M: SY='C';  M=-19,-36,150,-45,-45,-40,-29,-25,-20,-41,-57,-45,-26,-18,-44,-31,  0,-18,-20,-70,  5,-44;
/M: SY='G';  M= 10, 10,-21, 10, 10,-31, 12,-10, -1,-10,-21,-11,  1,  9,  0,-11, 10, 10, -1,-61,-31,  0;
/I:         I=-13; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='I';  M=  0,-19,-20,-20,-19, 19,-19,-20, 39,-20, 30, 20,-10,-10,-19,-20,-10,  0, 31,-51, -1,-19;
/M: SY='I';  M=  0,-20,-20,-20,-20, 20,-20,-20, 40,-20, 30, 20,-10,-10,-20,-20,-10,  0, 30,-50,  0,-20;
/M: SY='M';  M=-11,-21,-50,-21,-21, 13,-21,-10, 20, -2, 40, 49,-11,-11,-11, -1,-11, -1, 19,-38, -7,-11;
/M: SY='F';  M=-29,-39,-40,-49,-49,107,-49,-20, 20,-49, 30, 10,-30,-39,-39,-40,-30,-29,  1, 18, 97,-49;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='V';  M=  0,-10,-20,-19,-10, -1, -9,-20, 29,-20, 29, 19,-10,-10,-10,-20,-10,  0, 39,-60,-21,-10;
/M: SY='A';  M= 10,  2,-20,  2,  2,-30, 10,-10,  0, -1,-12, -2,  0, 10,  0, -1, 10, 10,  0,-51,-30,  0;
/M: SY='A';  M= 10, 10, -3, 10,  2,-30, 10, -2, -8, -2,-20,-10,  8, 10,  0, -2, 10, 10, -8,-35,-30,  0;
/M: SY='R';  M= -7,  2,-34,  2,  0,-39,-15, 16,-18, 34,-28, -2, 10,  2,  8, 42,  2,  2,-18, 18,-38,  8;
/M: SY='V';  M=  0, -6,-24,-12, -6, -3, -8,-14, 22,-14, 19, 14, -7, -7, -8,-15, -6,  0, 26,-53,-19, -8;
/M: SY='A';  M= 10,  0,-20,  0,  0,-30, 10,-10,  0,  0,-10,  0,  0, 10,  0,  0, 10, 10,  0,-50,-30,  0;
/M: SY='Y';  M=-30,-30, 10,-40,-40,100,-50,  0,  0,-40,  0,-10,-30,-50,-40,-40,-30,-30,-20, 10,130,-40;
/M: SY='K';  M= -8, 12,-47, 12, 12,-47, -7, 10,-18, 35,-22, -2, 10,  0, 10, 35,  2,  0,-18,-32,-38, 10;
/M: SY='B';  M=  0, 20,-30, 20, 20,-30, 10, 10,-10, 10,-30,-10, 10,  0, 10, 10, 10,  0,-10,-40,-30, 10;
/M: SY='V';  M=  0,-10,-20,-20,-10,  0,-10,-20, 30,-20, 30, 20,-10,-10,-10,-20,-10,  0, 40,-60,-20,-10;
/M: SY='P';  M=  7,  2,-25,  2,  2,-42, -2,  2,-12,  6,-20, -8,  2, 42,  2,  6,  8,  8,-12,-55,-48,  2;
/M: SY='B';  M= -1, 16,-31, 16, 16,-32,  5, 10,-11, 14,-29, -8,  9,  1,  9, 16,  8,  1,-11,-30,-32,  9;
/M: SY='W';  M=-60,-50,-80,-70,-70, 20,-70,-20,-50,-30,-20,-40,-40,-60,-50, 30,-30,-50,-60,260, 10,-60;
/M: SY='H';  M=-12,  6,-29,  5,  5,-10,-13, 45,-17,  5,-17, -9,  7, -4, 24, 15, -2,-12,-19,-17, 10, 15;
/M: SY='R';  M=-10,  0,-40,  0,  0,-40,-20, 20,-20, 40,-30,  0, 10,  0, 10, 50,  0,  0,-20, 28,-40, 10;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='L';  M=-20,-30,-60,-30,-30, 30,-30,-20, 30,-20, 70, 40,-30,-20,-20,-30,-20,-10, 30,-20,  0,-20;
/M: SY='V';  M=  0,-11, -9,-18,-11, -5,-10,-19, 23,-19, 19, 12, -9, -9,-12,-19, -8, -1, 30,-60,-18,-11;
/M: SY='R';  M=-10,  0,-40,  0,  0,-40,-20, 20,-20, 40,-30,  0, 10,  0, 10, 50,  0,  0,-20, 30,-40, 10;
/M: SY='V';  M=  0,-10,-20,-20,-10,  0,-10,-20, 30,-20, 30, 20,-10,-10,-10,-20,-10,  0, 40,-60,-20,-10;
/M: SY='C';  M=-20,-40,163,-49,-49,-38,-30,-30,-18,-49,-56,-47,-30,-20,-49,-40, -1,-20,-18,-78, 10,-49;
/M: SY='D';  M= 10, 18,-47, 27, 27,-50, 15,  7,-20,  7,-30,-20, 18,  0, 17, -3,  2,  2,-10,-70,-42, 25;
/M: SY='D';  M=  1, 19,-32, 20, 20,-33, 10, 10,-12,  9,-29,-12, 11,  0, 11,  8, 10,  0,-11,-44,-31, 11;
/M: SY='I';  M=  0,-20,-20,-20,-20, 19,-19,-20, 39,-20, 30, 20,-10,-10,-20,-20,-10,  0, 30,-50, -1,-20;
/M: SY='P';  M= 10,  0,-20,  0,  0,-40,  0,  0,-10,  0,-20,-10,  0, 50,  0,  0, 10, 10,-10,-60,-50,  0;
/M: SY='I';  M= -1,-20,-22,-20,-20, 19,-20,-19, 39,-19, 31, 22,-10,-10,-19,-19,-10,  0, 29,-49, -1,-19;
/M: SY='V';  M=  0,-10,-20,-20,-10,  0,-10,-20, 30,-20, 30, 20,-10,-10,-10,-20,-10,  0, 40,-60,-20,-10;
/M: SY='L';  M=-17,-28,-54,-28,-28, 28,-28,-20, 32,-20, 64, 37,-27,-18,-20,-28,-18, -8, 30,-25,  0,-20;
/M: SY='C';  M=-19,-39,163,-49,-48,-39,-29,-30,-18,-49,-57,-48,-29,-19,-48,-39,  0,-19,-18,-79,  9,-48;
/M: SY='G';  M= 10, 10,-30, 10, 10,-50, 40,-10,-20,-10,-30,-20, 10,  0,  0,-20, 10, 10,-10,-70,-50,  0;
/M: SY='B';  M=  0, 20,-30, 20, 20,-30, 10, 10,-10, 10,-30,-10, 10,  0, 10, 10, 10,  0,-10,-40,-30, 10;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 10,-20, 40,-20,  0, 10,  0, 10, 40,  0,  0,-20,-30,-40, 10;
/M: SY='V';  M=  0,-10,-20,-20,-10,  0,-10,-20, 30,-20, 30, 20,-10,-10,-10,-20,-10,  0, 40,-60,-20,-10;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0, 10,  0,-20,-70,-40, 20;
/M: SY='I';  M=  0,-18,-21,-20,-18, 15,-18,-20, 37,-19, 30, 21,-10,-10,-17,-19,-10,  0, 32,-52, -5,-17;
/M: SY='K';  M= -8,  7,-50,  8,  8,-40, -9,  8,-14, 29,-12,  5,  8, -2,  9, 28, -2,  0,-12,-36,-35,  9;
/M: SY='D';  M=  6, 18,-46, 26, 26,-44,  7, 16,-19, 10,-28,-18, 18,  0, 21,  4,  8, -2,-18,-60,-33, 20;
/M: SY='R';  M=-10,  2,-42,  2,  2,-42,-18, 18,-20, 40,-28,  0, 10,  0, 10, 48,  0,  0,-20, 21,-40, 10;
/M: SY='K';  M= -9, 11,-50, 11, 11,-49, -9, 11,-20, 38,-20, -1, 10,  0, 11, 38,  0,  0,-19,-31,-40, 11;
/M: SY='V';  M=  2, -8,-20,-17, -8, -5, -7,-18, 25,-17, 24, 17, -8, -7, -8,-17, -7,  2, 34,-58,-22, -8;
/M: SY='R';  M=-18,  1,-55, -2, -2,-39,-19,  5,-25, 29,-20, -6,  2, -9,  1, 38, -5, -8,-26, 15,-32, -1;
/M: SY='B';  M=  7, 10,-25, 10, 10,-33,  7, -7, -3, -2,-20, -8,  2,  8,  2, -2,  8,  8, -3,-55,-32,  2;
/M: SY='K';  M= -9, 10,-49, 10, 10,-50, -8,  9,-20, 38,-20, -1, 10,  0, 10, 37,  0,  0,-20,-32,-40, 10;
/M: SY='G';  M=  8, 10,-17, 10,  5,-35, 13,  1,-11, -1,-20,-10,  7,  7,  5, -2,  8,  8, -7,-45,-35,  3;
/M: SY='I';  M=  0,-16,-20,-20,-16, 13,-16,-20, 36,-20, 30, 20,-10,-10,-16,-20,-10,  0, 34,-54, -7,-16;
/M: SY='V';  M=  6,  0,-25, -2,  2,-22,  3,-10,  7, -5,  1,  4,  0,  1,  0, -7,  3,  5, 11,-56,-28,  0;
/M: SY='F';  M=-33,-41,-44,-52,-52,101,-52,-20, 13,-48, 25,  5,-31,-42,-41,-33,-30,-32, -6, 43, 91,-51;
/M: SY='H';  M= -7, 12,-33, 13, 13,-25, -7, 44,-20, 10,-22,-12, 12,  0, 28, 17,  2, -8,-20,-28, -6, 20;
/M: SY='R';  M=-10,  0,-40,  0,  0,-40,-20, 20,-20, 40,-30,  0, 10,  0, 10, 50,  0,  0,-20, 30,-40, 10;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 10,-20, 40,-20,  0, 10,  0, 10, 40,  0,  0,-20,-30,-40, 10;
/M: SY='K';  M= -7,  8,-45,  8,  8,-47, -7,  7,-17, 34,-18,  0,  8,  2,  8, 34,  2,  2,-17,-33,-38,  8;
/I:         I=-15; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='B';  M=  0, 18,-31, 18, 18,-28,  9,  9, -9, 10,-27, -7,  9,  0,  9, 10,  9,  0, -9,-40,-29,  9;
/M: SY='L';  M=-17,-28,-53,-28,-28, 28,-28,-20, 32,-20, 63, 37,-27,-18,-20,-28,-18, -8, 30,-25,  0,-20;
/M: SY='H';  M= -4, 12,-41, 12, 12,-19, -7, 23,-17,  2,-18,-11,  5, -8, 18,  1, -5, -5,-12,-43,-13, 12;
/M: SY='Y';  M=-26,-28, -4,-37,-36, 80,-43, -5,  8,-35, 14,  1,-28,-42,-34,-37,-27,-24, -7, -1, 96,-34;
/M: SY='Y';  M=-23,-31, 34,-39,-39, 61,-42,-10,  3,-39, -5,-12,-27,-38,-39,-37,-21,-23,-11,-16, 86,-39;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0,  7,  0,-17,-70,-40, 23;
/M: SY='I';  M= -3,-18,-27,-18,-18, 12,-20,-15, 31,-11, 26, 23, -8, -9,-15,-10, -9,  0, 24,-41, -6,-15;
/M: SY='A';  M= 10, 10,  0, 10,  0,-30, 10,  0,-10,  0,-20,-10, 10, 10,  0,  0, 10, 10,-10,-30,-30,  0;
/M: SY='A';  M=  9,  8,-20,  7,  8,-27,  8,-11,  3,-11,-15, -7, -1,  8, -1,-11,  8,  9,  4,-60,-29, -1;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 10,-20, 40,-20,  0, 10,  0, 10, 40,  0,  0,-20,-30,-40, 10;
/M: SY='C';  M=  7,  5, 18,  4, -5,-31,  6, -3,-11, -5,-24,-14,  6,  7, -5, -4,  9,  7,-11,-35,-26, -5;
/M: SY='B';  M=  0, 20,-30, 20, 20,-30, 10, 10,-10, 10,-30,-10, 10,  0, 10, 10, 10,  0,-10,-40,-30, 10;
/M: SY='Y';  M=-28,-26,  3,-35,-35, 88,-46,  4, -1,-35, -1, -9,-26,-44,-33,-34,-27,-28,-19,  7,115,-34;
/M: SY='B';  M=  0, 20,-30, 20, 20,-30, 10, 10,-10, 10,-30,-10, 10,  0, 10, 10, 10,  0,-10,-40,-30, 10;
/M: SY='F';  M=-24,-34,-39,-43,-41, 83,-41,-20, 23,-42, 34, 15,-27,-33,-33,-36,-26,-23, 10,  2, 69,-40;
/M: SY='D';  M= 10, 20,-50, 30, 30,-50, 10, 10,-20, 10,-30,-20, 20,  0, 20,  0,  0,  0,-10,-70,-40, 30;
/M: SY='K';  M=-10, 10,-50, 10, 10,-50,-10, 10,-20, 40,-20,  0, 10,  0, 10, 40,  0,  0,-20,-30,-40, 10;
/M: SY='P';  M= 10,  0,-20,  0,  0,-40,  0,  0,-10,  0,-20,-10,  0, 50,  0,  0, 10, 10,-10,-60,-50,  0;
/M: SY='F';  M=-30,-40,-40,-50,-50,110,-50,-20, 20,-50, 30, 10,-30,-40,-40,-40,-30,-30,  0, 20,100,-50;
/M: SY='L';  M=-16,-26,-53,-28,-26, 25,-26,-20, 30,-20, 63, 36,-26,-18,-18,-28,-18, -8, 32,-27, -4,-18;
/M: SY='W';  M=-46,-42,-46,-57,-57, 41,-59,-15,-27,-32, -6,-23,-36,-52,-44,  2,-28,-39,-38,151, 42,-50;
/M: SY='L';  M=-21,-30,-60,-31,-31, 29,-31,-20, 27,-20, 67, 38,-30,-21,-21,-27,-20,-11, 27,-13,  0,-21;
/M: SY='I';  M=  2,  0,-29, -1, -1,-10, -1,-12,  7,-14, -1,  0, -7,  1, -6,-15,  2,  4,  5,-48,-17, -7;
/M: SY='R';  M=-10,  1,-41,  1,  1,-41,-19, 19,-20, 40,-29,  0, 10,  0, 10, 49,  0,  0,-20, 26,-40, 10;
/M: SY='R';  M=-10,  9,-49,  9,  9,-49,-11, 11,-20, 40,-21,  0, 10,  0, 10, 41,  0,  0,-20,-27,-40, 10;
/M: SY='L';  M=-19,-30,-59,-30,-30, 30,-30,-20, 30,-20, 69, 39,-29,-20,-20,-30,-20,-10, 30,-21,  0,-20;
/M: SY='V';  M=  3, -5,-17, -9, -7, -7, -5,-14, 19,-14, 11,  9, -5, -2, -9,-14, -2,  4, 20,-53,-19, -9;
/I:         I=-15; MD=-32;
/M: SY='G';  M=  8, 11,-29, 11, 11,-45, 35, -7,-18, -7,-29,-18, 10,  0,  1,-16, 10,  8,-10,-63,-45,  1; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='D';  M=  9, 19,-48, 28, 28,-48,  9, 10,-19, 10,-28,-18, 18,  0, 19,  1,  9,  0,-18,-67,-39, 19;
/I:         E1=0; IE=-105; DE=-105;

» more

Post-processing [info]

COMPETES_HIT_WITH

PS51417; PS51419; PS51420; PS51421; PS51422; PS51423; PS51424; PS52057

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	51 in 51 different sequences
Number of true positive hits	51 in 51 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Small GTPase Ran-type
Version [info]	8

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

51 sequences

GSP1_CANAW  (Q9P4E9), GSP1_CANGA  (Q6FR65), GSP1_ENCCU  (Q8SS11),

GSP1_EREGS  (Q74ZA9), GSP1_NEUCR  (Q7RVL0), GSP1_YARLI  (Q8TFK3), 
GSP1_YEAST  (P32835), GSP2_YEAST  (P32836), RAN1A_LOTJA (P54765), 
RAN1B_LOTJA (P54766), RAN1_ARATH  (P41916), RAN1_ORYSI  (A2WSI7), 
RAN1_ORYSJ  (Q7F7I7), RAN1_SOLLC  (P38546), RAN2_ARATH  (P41917), 
RAN2_ORYSI  (A2Y7R5), RAN2_ORYSJ  (Q7GD79), RAN2_SOLLC  (P38547), 
RAN3_ARATH  (Q8H156), RAN3_ORYSI  (A2YEQ6), RAN3_ORYSJ  (Q69XM7), 
RAN4_ARATH  (Q9FLQ3), RANA1_TOBAC (P41918), RANB1_TOBAC (P41919), 
RANL_DROME  (Q9VUN3), RANT_MOUSE  (Q61820), RANT_RAT(Q8K586), 
RAN_BOVIN   (Q3T054), RAN_BRUMA   (P38542), RAN_CAEEL   (O17915), 
RAN_CANLF   (P62825), RAN_CARAU   (Q7ZZX9), RAN_CHICK   (P42558), 
RAN_DANRE   (P79735), RAN_DICDI   (P33519), RAN_DROME   (Q9VZ23), 
RAN_GIAIN   (P38543), RAN_HUMAN   (P62826), RAN_MACFA   (Q4R4M9), 
RAN_MOUSE   (P62827), RAN_ONCVO   (P38544), RAN_PLAFA   (P38545), 
RAN_PONAB   (Q5R556), RAN_RAT (P62828), RAN_SALSA   (Q9YGC0), 
RAN_TETPY   (P41914), RAN_TETTH   (P41915), RAN_VICFA   (P38548), 
RAN_XENLA   (P52301), RAN_XENTR   (Q6GL85), SPI1_SCHPO  (P28748)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

150 PDB

1BYU; 1I2M; 1IBR; 1K5D; 1K5G; 1QBK; 1QG2; 1QG4; 1RRP; 1WA5; 2BKU; 2MMC; 2MMG; 2N1B; 2X19; 3A6P; 3CH5; 3EA5; 3GJ0; 3GJ3; 3GJ4; 3GJ5; 3GJ6; 3GJ7; 3GJ8; 3GJX; 3ICQ; 3M1I; 3NBY; 3NBZ; 3NC0; 3NC1; 3RAN; 3W3Z; 3WYG; 3ZJY; 4C0Q; 4DJT; 4GMX; 4GPT; 4HAT; 4HAU; 4HAV; 4HAW; 4HAX; 4HAY; 4HAZ; 4HB0; 4HB2; 4HB3; 4HB4; 4OL0; 4WVF; 5BXQ; 5CIQ; 5CIT; 5CIW; 5CJ2; 5CLL; 5CLQ; 5DH9; 5DHA; 5DHF; 5DI9; 5DIF; 5DIS; 5DLQ; 5JLJ; 5UWH; 5UWI; 5UWJ; 5UWO; 5UWP; 5UWQ; 5UWR; 5UWS; 5UWT; 5UWU; 5UWW; 5YRO; 5YST; 5YSU; 5YTB; 5YU6; 5ZPU; 6A38; 6A3A; 6A3B; 6A3C; 6A3E; 6CIT; 6KFT; 6LQ9; 6M60; 6M6X; 6Q82; 6Q84; 6TVO; 6X2M; 6X2O; 6X2P; 6X2R; 6X2S; 6X2U; 6X2V; 6X2W; 6X2X; 6X2Y; 6XJP; 6XJR; 6XJS; 6XJT; 6XJU; 7B51; 7CND; 7DBG; 7L5E; 7MNP; 7MNQ; 7MNR; 7MNS; 7MNT; 7MNU; 7MNV; 7MNW; 7MNX; 7MNY; 7MNZ; 7MO0; 7MO1; 7MO2; 7MO3; 7MO4; 7MO5; 7YPZ; 8DYO; 8F19; 8F1E; 8F7A; 8HQ3; 8HQ4; 8HQ5; 8HQ6; 8HUF; 8HUG; 8ITV; 8QYZ; 8UX1; 9B3I; 9B62
» more