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annotation rule: PRU00772

General rule information [?]

Accession PRU00772
Dates 20-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51442; M_PRO
Names Coronavirus main protease (M-pro) domain; 3C-like proteinase (3CL-pro); peptidase family C30
Function It is a viral cysteine proteinase wich mediates most maturation cleavage events within the precursor polyprotein.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Function The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.

Gene Ontology [?]

GO:0019082; Biological process: viral protein processing.
GO:0006508; Biological process: proteolysis.
GO:0008233; Molecular function: peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008234; Molecular function: cysteine-type peptidase activity.

Keywords [?]

end case

Features [?]

From: PS51442
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C30 #        
ACT_SITE     41     41       For 3CL-PRO activity     H   1
ACT_SITE     144     144       For 3CL-PRO activity     C   1

Additional information [?]

Size range 292-317 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6Y1 (R1AB_IBVB)
Viruses; Coronavirinae
Comments None


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UniProtKB rule member sequences [?]