ProRule PRU00772
General rule information
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| Accession | PRU00772 |
| Dates | 20-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51442; M_PRO |
Name | Coronavirus main protease (M-pro) domain |
| Function | It is a viral cysteine proteinase wich mediates most maturation cleavage events within the precursor polyprotein. |
| Scope(s) |
Viruses Coronavirinae |
| Example(s) | P0C6Y1 (R1AB_IBVB); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| FUNCTION | The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]- Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu- Gln-CMK. |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| GO:0019082; Biological process:viral protein processing |
| GO:0006508; Biological process:proteolysis |
| GO:0008233; Molecular function:peptidase activity |
| GO:0016787; Molecular function:hydrolase activity |
| GO:0008234; Molecular function:cysteine-type peptidase activity |
Features
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| From: PS51442 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C30 #" | |||||||||
| ACT_SITE | 41 | 41 | /note="For 3CL-PRO activity" | H | 1 | |||||||
| ACT_SITE | 144 | 144 | /note="For 3CL-PRO activity" | C | 1 | |||||||
Additional information
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| Size range | 292-317 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [59] All [ 59 ]
- Retrieve set of proteins with 3D structure for this domain