PROSITE logo

ProRule PRU00772


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00772
Accession PRU00772
Dates 20-JUL-2010 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51442; M_PRO
Name Coronavirus main protease (M-pro) domain
Function It is a viral cysteine proteinase wich mediates most maturation cleavage events within the precursor polyprotein.
Scope(s) Viruses
Coronavirinae
Example(s) P0C6Y1 (R1AB_IBVB);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
FUNCTIONThe main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]- Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu- Gln-CMK.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

GO:0019082; Biological process:viral protein processing
GO:0006508; Biological process:proteolysis
GO:0008233; Molecular function:peptidase activity
GO:0016787; Molecular function:hydrolase activity
GO:0008234; Molecular function:cysteine-type peptidase activity

Features [?]

From: PS51442
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C30 #"
ACT_SITE 41 41 /note="For 3CL-PRO activity" H 1
ACT_SITE 144 144 /note="For 3CL-PRO activity" C 1

Additional information [?]

Size range 292-317 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]