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annotation rule: PRU00772 |
Accession | PRU00772 |
Dates | 20-JUL-2010 (Created) 21-NOV-2019 (Last updated, Version 5) |
Data class | Domain |
Predictors | PROSITE; PS51442; M_PRO |
Names | Coronavirus main protease (M-pro) domain; 3C-like proteinase (3CL-pro); peptidase family C30 |
Function | It is a viral cysteine proteinase wich mediates most maturation cleavage events within the precursor polyprotein. |
Function | The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. |
From: PS51442 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase C30 # | |||||||||
ACT_SITE | 41 | 41 | For 3CL-PRO activity | H | 1 | |||||||
ACT_SITE | 144 | 144 | For 3CL-PRO activity | C | 1 |
Size range | 292-317 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6Y1 (R1AB_IBVB) |
Scope | Viruses; Coronavirinae |
Comments | None |
Viruses | [59] |