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ProRule PRU00773


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PURL: https://purl.expasy.org/prosite/rule/PRU00773
General rule information [?]

Accession PRU00773
Dates 08-APR-2009 (Created)
17-FEB-2023 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51443; PCS
Name Phytochelatin synthase (PCS) domain
Function Phytochelatins (PCs) are synthesized posttranslationally by the PC synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC) transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1) formation of gamma-EC concomitant with the cleavage of Gly from GSH; and (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an oligomeric PC peptide (PCn).
Scope(s) Eukaryota
Bacteria
Cyanobacteriota
Example(s) Q2TE74;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + AltName: Full=Glutathione gamma-glutamylcysteinyltransferase;
                 EC=2.3.2.15;
end case

Comments [?]

case <FTGroup:1>
CATALYTIC ACTIVITY Reaction=[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine; Xref=Rhea:RHEA:17917, Rhea:RHEA-COMP:12438, Rhea:RHEA- COMP:12439, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:131728; EC=2.3.2.15;
end case
SIMILARITYBelongs to the phytochelatin synthase family.

Keywords [?]

Transferase
Acyltransferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016756; Molecular function:glutathione gamma-glutamylcysteinyltransferase activity
GO:0046938; Biological process:phytochelatin biosynthetic process
GO:0016746; Molecular function:acyltransferase activity

Features [?]

From: PS51443
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C83 #"
ACT_SITE 56 56 C 1
ACT_SITE 168 168 H 1
ACT_SITE 186 186 D 1

Additional information [?]

Size range 210-231 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]