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annotation rule: PRU00773

General rule information [?]

Accession PRU00773
Dates 8-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51443; PCS
Name Phytochelatin synthase (PCS) domain
Function Phytochelatins (PCs) are synthesized posttranslationally by the PC synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC) transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1) formation of gamma-EC concomitant with the cleavage of Gly from GSH; and (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an oligomeric PC peptide (PCn).

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ AltName: Full=Glutathione gamma-glutamylcysteinyltransferase; EC 2.3.2.15;
end case


Comments [?]

case <FTGroup:1>
Catalytic activity RHEA:17917: [Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine
EC 2.3.2.15
end case

Similarity Belongs to the phytochelatin synthase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0016756; Molecular function: glutathione gamma-glutamylcysteinyltransferase activity.
GO:0046938; Biological process: phytochelatin biosynthetic process.
GO:0016746; Molecular function: transferase activity, transferring acyl groups.

Keywords [?]

end case


Features [?]

From: PS51443
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C83 #        
ACT_SITE     56     56             C   1
ACT_SITE     168     168             H   1
ACT_SITE     186     186             D   1

Additional information [?]

Size range 210-231 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q2TE74 (PCS2_LOTJA)
Scope
Eukaryota
Bacteria; Cyanobacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [7]