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| annotation rule: PRU00773 |
General rule information
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| Accession | PRU00773 |
| Dates | 8-APR-2009 (Created) 3-JUN-2021 (Last updated, Version 9) |
| Data class | Domain |
| Predictors | PROSITE; PS51443; PCS |
| Name | Phytochelatin synthase (PCS) domain |
| Function | Phytochelatins (PCs) are synthesized posttranslationally by the PC synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC) transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1) formation of gamma-EC concomitant with the cleavage of Gly from GSH; and (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an oligomeric PC peptide (PCn). |
Propagated annotation
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Description
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case <FTGroup:1>
| + AltName: Full=Glutathione gamma-glutamylcysteinyltransferase; EC 2.3.2.15; |
end case
Comments
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case <FTGroup:1>
| Catalytic activity | RHEA:17917: [Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine
EC 2.3.2.15 |
end case
| Similarity | Belongs to the phytochelatin synthase family. |
Gene Ontology
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case <FTGroup:1>
GO:0016756; Molecular function: glutathione gamma-glutamylcysteinyltransferase activity.
GO:0046938; Biological process: phytochelatin biosynthetic process.
GO:0016746; Molecular function: acyltransferase activity.
GO:0046938; Biological process: phytochelatin biosynthetic process.
GO:0016746; Molecular function: acyltransferase activity.
Keywords
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end case
Features
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| From: PS51443 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase C83 # | |||||||||
| ACT_SITE | 56 | 56 | C | 1 | ||||||||
| ACT_SITE | 168 | 168 | H | 1 | ||||||||
| ACT_SITE | 186 | 186 | D | 1 | ||||||||
Additional information
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| Size range | 210-231 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q2TE74 (PCS2_LOTJA) |
| Scope | Eukaryota
Bacteria; Cyanobacteria |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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