General rule information
[?]
Accession |
PRU00773 |
Dates |
8-APR-2009 (Created) 3-JUN-2021 (Last updated, Version 9) |
Name |
Phytochelatin synthase (PCS) domain |
Function |
Phytochelatins (PCs) are synthesized posttranslationally by the PC synthase (PCS) (EC 2.3.2.15), a gamma-glutamylcysteine (gamma-EC) transpeptidase. PC synthesis is proposed to have two distinct steps: (Step1) formation of gamma-EC concomitant with the cleavage of Gly from GSH; and (Step 2) transfer of the gamma-EC unit to an acceptor GSH molecule or an oligomeric PC peptide (PCn). |
Propagated annotation
[?]
case <FTGroup:1>
+ AltName: Full=Glutathione gamma-glutamylcysteinyltransferase;
EC 2.3.2.15; |
end case
case <FTGroup:1>
Catalytic activity |
RHEA:17917: [Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine
EC 2.3.2.15
|
end case
Similarity |
Belongs to the phytochelatin synthase family. |
case <FTGroup:1>
GO:0016756; Molecular function: glutathione gamma-glutamylcysteinyltransferase activity.
GO:0046938; Biological process: phytochelatin biosynthetic process.
GO:0016746; Molecular function: acyltransferase activity.
end case
From: PS51443 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase C83 #
|
|
|
|
|
|
|
ACT_SITE
|
|
56
|
|
56
|
|
|
|
|
|
C
|
|
1
|
ACT_SITE
|
|
168
|
|
168
|
|
|
|
|
|
H
|
|
1
|
ACT_SITE
|
|
186
|
|
186
|
|
|
|
|
|
D
|
|
1
|
Additional information
[?]
Size range |
210-231 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q2TE74 (PCS2_LOTJA) |
Scope |
Eukaryota
Bacteria; Cyanobacteria |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]
UniProtKB/Swiss-Prot sets