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annotation rule: PRU00774

General rule information [?]

Accession PRU00774
Dates 8-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51444; FH2
Name Formin homology-2 (FH2) domain
Function The defining feature of formins is a highly conserved ~400 residue region, the Formin Homology-2 (FH2) domain, which forms a head-to-tail ring- shaped dimer, and directly binds to the actin filament at its barbed end. The FH2 domain catalyzes the nucleation and elongation of actin filament, preventing capping proteins from binding to the barbed end.

Propagated annotation [?]

Gene Ontology [?]

GO:0003779; Molecular function: actin binding.
GO:0030036; Biological process: actin cytoskeleton organization.
GO:0005856; Cellular component: cytoskeleton.

Keywords [?]

Features [?]

From: PS51444
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       FH2 #        

Additional information [?]

Size range 285-486 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O60610 (DIAP1_HUMAN)
Comments None


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UniProtKB rule member sequences [?]