ProRule PRU00774
General rule information
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| Accession | PRU00774 |
| Dates | 8-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51444; FH2 |
Name | Formin homology-2 (FH2) domain |
| Function | The defining feature of formins is a highly conserved ~400 residue region, the Formin Homology-2 (FH2) domain, which forms a head-to-tail ring- shaped dimer, and directly binds to the actin filament at its barbed end. The FH2 domain catalyzes the nucleation and elongation of actin filament, preventing capping proteins from binding to the barbed end. |
| Scope(s) |
Eukaryota |
| Example(s) | O60610 (DIAP1_HUMAN); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0003779; Molecular function:actin binding |
| GO:0030036; Biological process:actin cytoskeleton organization |
| GO:0005856; Cellular component:cytoskeleton |
Features
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| From: PS51444 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="FH2 #" | |||||||||
Additional information
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| Size range | 285-486 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [105] All [ 105 ]
- Retrieve set of proteins with 3D structure for this domain