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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00774


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00774
General rule information [?]

Accession PRU00774
Dates 08-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51444; FH2
Name Formin homology-2 (FH2) domain
Function The defining feature of formins is a highly conserved ~400 residue region, the Formin Homology-2 (FH2) domain, which forms a head-to-tail ring- shaped dimer, and directly binds to the actin filament at its barbed end. The FH2 domain catalyzes the nucleation and elongation of actin filament, preventing capping proteins from binding to the barbed end.
Scope(s) Eukaryota
Example(s) O60610;

Propagated annotation [?]

Keywords [?]

Actin-binding
Cytoskeleton

Gene Ontology [?]

GO:0003779; Molecular function:actin binding
GO:0030036; Biological process:actin cytoskeleton organization
GO:0005856; Cellular component:cytoskeleton

Features [?]

From: PS51444
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="FH2 #"

Additional information [?]

Size range 285-486 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]