ProRule PRU00774

General rule information [?]

Accession PRU00774
Dates 8-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51444; FH2
Name Formin homology-2 (FH2) domain
Function The defining feature of formins is a highly conserved ~400 residue region, the Formin Homology-2 (FH2) domain, which forms a head-to-tail ring- shaped dimer, and directly binds to the actin filament at its barbed end. The FH2 domain catalyzes the nucleation and elongation of actin filament, preventing capping proteins from binding to the barbed end.
Scope(s) Eukaryota
Example(s) O60610 (DIAP1_HUMAN);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0003779; Molecular function:actin binding
GO:0030036; Biological process:actin cytoskeleton organization
GO:0005856; Cellular component:cytoskeleton

Features [?]

From: PS51444
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="FH2 #"

Additional information [?]

Size range 285-486 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]