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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00776


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00776
General rule information [?]

Accession PRU00776
Dates 15-APR-2009 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51446; PACIFASTIN
Name Pacifastin domain
Function Fill in
Scope(s) Eukaryota
Arthropoda
Example(s) O46163;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the protease inhibitor I19 family.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
Protease inhibitor
Serine protease inhibitor

Gene Ontology [?]

GO:0004866; Molecular function:endopeptidase inhibitor activity
GO:0004867; Molecular function:serine-type endopeptidase inhibitor activity

Features [?]

From: PS51446
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Pacifastin #"
SITE 29 30 /note="Reactive bond" x-K
DISULFID 4 19 disulf C-x*-C
DISULFID 14 32 disulf C-x*-C
DISULFID 17 27 disulf C-x*-C

Additional information [?]

Size range 25-48 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]