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annotation rule: PRU00780

General rule information [?]

Accession PRU00780
Dates 28-MAY-2009 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51449; MTTASE_N
Predictors PROSITE; PS01278; MTTASE_RADICAL
Name Methylthiotransferase domains
Function Methylthiotransferases (MTTases) catalyze a C-H to C-S bond conversion in the methylthiolation of tRNA or ribosomal protein substrate.

Propagated annotation [?]


Description [?]

case <OC:Bacteria> or <OC:Archaea>
+ RecName: EC 2.-.-.-;
end case


Comments [?]

Cofactor [4Fe-4S] cluster
Note: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
case <OC:Bacteria>
Subcellular location Cytoplasm.
end case


Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
case <OC:Bacteria> or <OC:Archaea>
GO:0016740; Molecular function: transferase activity.
end case

case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.
end case


Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
end case

case <OC:Bacteria>
end case


Features [?]

From: PS51449
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MTTase N-terminal #        
METAL     10     10       Iron-sulfur (4Fe-4S)     C  
METAL     46     46       Iron-sulfur (4Fe-4S)     C  
METAL     77     77       Iron-sulfur (4Fe-4S)     C  
From: PS01278
METAL     4     4       Iron-sulfur (4Fe-4S-S-AdoMet)        
METAL     5     5       Iron-sulfur (4Fe-4S-S-AdoMet)        
METAL     8     8       Iron-sulfur (4Fe-4S-S-AdoMet)        

Additional information [?]

Size range 90-150 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q54KV4 (CK5P1_DICDI); B4RNW8 (MIAB_NEIG2): [Recover all]
Scope
Bacteria
Eukaryota
Archaea
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]