General rule information
[?]
Accession |
PRU00780 |
Dates |
28-MAY-2009 (Created) 21-NOV-2019 (Last updated, Version 8) |
Predictors |
PROSITE; PS51449; MTTASE_N
|
Predictors |
PROSITE; PS01278; MTTASE_RADICAL
|
Name |
Methylthiotransferase domains |
Function |
Methylthiotransferases (MTTases) catalyze a C-H to C-S bond conversion in the methylthiolation of tRNA or ribosomal protein substrate. |
Propagated annotation
[?]
case <OC:Bacteria> or <OC:Archaea>
end case
Cofactor |
[4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
case <OC:Bacteria>
Subcellular location |
Cytoplasm. |
end case
GO:0005506; Molecular function: iron ion binding.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
case <OC:Bacteria> or <OC:Archaea>
GO:0016740; Molecular function: transferase activity.
end case
case <OC:Bacteria>
end case
case <OC:Bacteria> or <OC:Archaea>
end case
case <OC:Bacteria>
end case
From: PS51449 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
MTTase N-terminal #
|
|
|
|
|
|
|
METAL
|
|
10
|
|
10
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
|
METAL
|
|
46
|
|
46
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
|
METAL
|
|
77
|
|
77
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
|
From: PS01278 |
METAL
|
|
4
|
|
4
|
|
Iron-sulfur (4Fe-4S-S-AdoMet)
|
|
|
|
|
|
|
METAL
|
|
5
|
|
5
|
|
Iron-sulfur (4Fe-4S-S-AdoMet)
|
|
|
|
|
|
|
METAL
|
|
8
|
|
8
|
|
Iron-sulfur (4Fe-4S-S-AdoMet)
|
|
|
|
|
|
|
Additional information
[?]
Size range |
90-150 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Examples |
Q54KV4 (CK5P1_DICDI); B4RNW8 (MIAB_NEIG2): [Recover all] |
Scope |
Bacteria
Eukaryota
Archaea |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]