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annotation rule: PRU00780

General rule information [?]

Accession PRU00780
Dates 28-MAY-2009 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51449; MTTASE_N
Name Methylthiotransferase domains
Function Methylthiotransferases (MTTases) catalyze a C-H to C-S bond conversion in the methylthiolation of tRNA or ribosomal protein substrate.

Propagated annotation [?]

Description [?]

case <OC:Bacteria> or <OC:Archaea>
+ RecName: EC 2.-.-.-;
end case

Comments [?]

Cofactor [4Fe-4S] cluster
Note: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
case <OC:Bacteria>
Subcellular location Cytoplasm.
end case

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
case <OC:Bacteria> or <OC:Archaea>
GO:0016740; Molecular function: transferase activity.
end case

case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.
end case

Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
end case

case <OC:Bacteria>
end case

Features [?]

From: PS51449
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MTTase N-terminal #        
BINDING     10     10       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1     C  
BINDING     46     46       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1     C  
BINDING     77     77       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1     C  
From: PS01278
BINDING     4     4       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet        
BINDING     5     5       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet        
BINDING     8     8       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet        

Additional information [?]

Size range 90-150 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q54KV4 (CK5P1_DICDI); B4RNW8 (MIAB_NEIG2): [Recover all]
Comments None


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UniProtKB rule member sequences [?]