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|
| annotation rule: PRU00780 |
General rule information
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| Accession | PRU00780 |
| Dates | 28-MAY-2009 (Created) 20-JAN-2022 (Last updated, Version 9) |
| Data class | Domain |
| Predictors | PROSITE; PS51449; MTTASE_N |
| Predictors | PROSITE; PS01278; MTTASE_RADICAL |
| Name | Methylthiotransferase domains |
| Function | Methylthiotransferases (MTTases) catalyze a C-H to C-S bond conversion in the methylthiolation of tRNA or ribosomal protein substrate. |
Propagated annotation
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Description
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case <OC:Bacteria> or <OC:Archaea>
| + RecName: EC 2.-.-.-; |
end case
Comments
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| Cofactor | [4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
case <OC:Bacteria>
| Subcellular location | Cytoplasm. |
end case
Gene Ontology
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GO:0005506; Molecular function: iron ion binding.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
case <OC:Bacteria> or <OC:Archaea>
GO:0016740; Molecular function: transferase activity.
end case
case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.
end case
Keywords
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case <OC:Bacteria> or <OC:Archaea>
end case
case <OC:Bacteria>
end case
Features
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| From: PS51449 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | MTTase N-terminal # | |||||||||
| METAL | 10 | 10 | Iron-sulfur (4Fe-4S) 1 | C | ||||||||
| METAL | 46 | 46 | Iron-sulfur (4Fe-4S) 1 | C | ||||||||
| METAL | 77 | 77 | Iron-sulfur (4Fe-4S) 1 | C | ||||||||
| From: PS01278 | ||||||||||||
| METAL | 4 | 4 | Iron-sulfur (4Fe-4S) 2; 4Fe-4S-S-AdoMet | |||||||||
| METAL | 5 | 5 | Iron-sulfur (4Fe-4S) 2; 4Fe-4S-S-AdoMet | |||||||||
| METAL | 8 | 8 | Iron-sulfur (4Fe-4S) 2; 4Fe-4S-S-AdoMet | |||||||||
Additional information
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| Size range | 90-150 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Examples | Q54KV4 (CK5P1_DICDI); B4RNW8 (MIAB_NEIG2): [Recover all] |
| Scope | Bacteria
Eukaryota
Archaea |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Archaea [5] Bacteria [1031] Eukaryota [15] All [ 1051 ]
- Retrieve set of proteins with 3D structure for this domain