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ProRule PRU00780


General rule information [?]

Accession PRU00780
Dates 28-MAY-2009 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51449; MTTASE_N
PROSITE; PS01278; MTTASE_RADICAL
Name Methylthiotransferase domains
Function Methylthiotransferases (MTTases) catalyze a C-H to C-S bond conversion in the methylthiolation of tRNA or ribosomal protein substrate.
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) Q54KV4 (CK5P1_DICDI); B4RNW8 (MIAB_NEIG2);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria> or <OC:Archaea>
Protein name + RecName: EC=2.-.-.-;
end case

Comments [?]

COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
case <OC:Bacteria>
SUBCELLULAR LOCATIONCytoplasm.
end case

Keywords [?]

4Fe-4S
Iron
Iron-sulfur
Metal-binding
S-adenosyl-L-methionine
case <OC:Bacteria> or <OC:Archaea>
Transferase
end case
case <OC:Bacteria>
Cytoplasm
end case

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
case <OCellular component:Bacteria> or <OC:Archaea>
GO:0016740; Molecular function:transferase activity
end case
case <OCellular component:Bacteria>
GO:0005737; Cellular component:cytoplasm
end case

Features [?]

From: PS51449
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MTTase N-terminal #"
BINDING 10 10 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"		 C
BINDING 46 46 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"		 C
BINDING 77 77 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="1"		 C
From: PS01278
Key From To Description Tag Condition FTGroup
BINDING 4 4 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"
BINDING 5 5 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"
BINDING 8 8 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_label="2"
/ligand_note="4Fe-4S-S-AdoMet"

Additional information [?]

Size range 90-150 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]