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ProRule PRU00796


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PURL: https://purl.expasy.org/prosite/rule/PRU00796
General rule information [?]

Accession PRU00796
Dates 10-SEP-2009 (Created)
11-NOV-2021 (Last updated, Version 7)
Data class Protein;
Predictors PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3
Name Glucose-6-phosphate isomerase family
Function Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) or phosphoglucose isomerase (PGI) is a glycolytic enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) Q39SU1 (G6PI_GEOMG);

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier G6PI
Protein name + RecName: Full=Glucose-6-phosphate isomerase;
                 Short=GPI;
                 EC=5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
                 Short=PGI;
AltName: Full=Phosphohexose isomerase;
                 Short=PHI;
Gene name Name=pgi;

Comments [?]

CATALYTIC ACTIVITY Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9;
PATHWAYCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the GPI family.

Keywords [?]

Gluconeogenesis
Glycolysis
Isomerase
Cytoplasm

Gene Ontology [?]

GO:0004347; Molecular function:glucose-6-phosphate isomerase activity
GO:0006096; Biological process:glycolytic process
GO:0006094; Biological process:gluconeogenesis
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00765; P_GLUCOSE_ISOMERASE_1; 1;
PROSITE PS00174; P_GLUCOSE_ISOMERASE_2; 1;

Features [?]

From: PS51463
Key From To Description Tag Condition FTGroup
ACT_SITE 328 328 /note="Proton donor" E
ACT_SITE 360 360 H
ACT_SITE 472 472 K

Additional information [?]

Size range 150-600 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]