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annotation rule: PRU00796

General rule information [?]

Accession PRU00796
Dates 10-SEP-2009 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Protein
Predictors PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3
Name Glucose-6-phosphate isomerase family
Function Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) or phosphoglucose isomerase (PGI) is a glycolytic enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.

Propagated annotation [?]


Description [?]

Identifier G6PI
+ RecName: Full=Glucose-6-phosphate isomerase; Short=GPI; EC 5.3.1.9; AltName: Full=Phosphoglucose isomerase; Short=PGI; AltName: Full=Phosphohexose isomerase; Short=PHI;
Gene name pgi

Comments [?]

Catalytic activity RHEA:11816: aldehydo-D-glucose 6-phosphate = keto-D-fructose 6-phosphate
EC 5.3.1.9
Pathway Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location Cytoplasm.
Similarity Belongs to the GPI family.

Cross-references [?]

PROSITE PS00765; P_GLUCOSE_ISOMERASE_1; 1;
case <Feature:PS51463:472=K>
PS00174; P_GLUCOSE_ISOMERASE_2; 1;
end case


Gene Ontology [?]

GO:0004347; Molecular function: glucose-6-phosphate isomerase activity.
GO:0006096; Biological process: glycolytic process.
GO:0006094; Biological process: gluconeogenesis.
GO:0005737; Cellular component: cytoplasm.

Keywords [?]


Features [?]

From: PS51463
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     328     328       Proton donor     E  
ACT_SITE     360     360             H  
ACT_SITE     472     472             K  

Additional information [?]

Size range 150-600 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q39SU1 (G6PI_GEOMG)
Scope
Bacteria
Eukaryota
Archaea
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]