ProRule PRU00796
General rule information
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| Accession | PRU00796 |
| Dates | 10-SEP-2009 (Created)
11-NOV-2021 (Last updated, Version 6) |
| Data class | Protein; |
| Predictors |
PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3 |
Name | Glucose-6-phosphate isomerase family |
| Function | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) or phosphoglucose isomerase (PGI) is a glycolytic enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. |
| Scope(s) |
Bacteria Eukaryota Archaea |
| Example(s) | Q39SU1 (G6PI_GEOMG); |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | G6PI |
| Protein name | + RecName: Full=Glucose-6-phosphate isomerase; Short=GPI; EC=5.3.1.9; AltName: Full=Phosphoglucose isomerase; Short=PGI; AltName: Full=Phosphohexose isomerase; Short=PHI; |
| Gene name | Name=pgi; |
Comments
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| CATALYTIC ACTIVITY | Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9; |
| PATHWAY | Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GPI family. |
Keywords
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Gene Ontology
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| GO:0004347; Molecular function:glucose-6-phosphate isomerase activity |
| GO:0006096; Biological process:glycolytic process |
| GO:0006094; Biological process:gluconeogenesis |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: PS51463 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 328 | 328 | /note="Proton donor" | E | ||||||||
| ACT_SITE | 360 | 360 | H | |||||||||
| ACT_SITE | 472 | 472 | K | |||||||||
Additional information
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| Size range | 150-600 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [6] Bacteria [569] Eukaryota [48] All [ 623 ]
- Retrieve set of proteins with 3D structure for this domain