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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00796


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00796
General rule information [?]

Accession PRU00796
Dates 10-SEP-2009 (Created)
11-NOV-2021 (Last updated, Version 7)
Data class Protein;
Predictors PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3
Name Glucose-6-phosphate isomerase family
Function Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) or phosphoglucose isomerase (PGI) is a glycolytic enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) Q39SU1;

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier G6PI
Protein name + RecName: Full=Glucose-6-phosphate isomerase;
                 Short=GPI;
                 EC=5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
                 Short=PGI;
AltName: Full=Phosphohexose isomerase;
                 Short=PHI;
Gene name Name=pgi;

Comments [?]

CATALYTIC ACTIVITY Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9;
PATHWAYCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the GPI family.

Keywords [?]

Gluconeogenesis
Glycolysis
Isomerase
Cytoplasm

Gene Ontology [?]

GO:0004347; Molecular function:glucose-6-phosphate isomerase activity
GO:0006096; Biological process:glycolytic process
GO:0006094; Biological process:gluconeogenesis
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00765; P_GLUCOSE_ISOMERASE_1; 1;
PROSITE PS00174; P_GLUCOSE_ISOMERASE_2; 1;

Features [?]

From: PS51463
Key From To Description Tag Condition FTGroup
ACT_SITE 328 328 /note="Proton donor" E
ACT_SITE 360 360 H
ACT_SITE 472 472 K

Additional information [?]

Size range 150-600 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]