ProRule PRU00798
General rule information
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| Accession | PRU00798 |
| Dates | 20-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51465; KAZAL_2 |
Name | Kazal domain |
| Function | Kazal-type inhibitors represent the most studied canonical proteinase inhibitors. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P00995 (ISK1_HUMAN); |
Propagated annotation
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Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
| Protease inhibitor | |
| Serine protease inhibitor | |
Gene Ontology
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| GO:0010466; Biological process:negative regulation of peptidase activity |
| GO:0004867; Molecular function:serine-type endopeptidase inhibitor activity |
Cross-references
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| PROSITE | PS00282; KAZAL_1; 1; |
Features
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| From: PS51465 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Kazal-like #" | |||||||||
| SITE | 15 | 16 | /note="Reactive bond" | |||||||||
| DISULFID | 7 | 36 | disulf | C-x*-C | ||||||||
| DISULFID | 13 | 32 | disulf | C-x*-C | ||||||||
| DISULFID | 21 | 53 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 28-76 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-9 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [385] All [ 385 ]
- Retrieve set of proteins with 3D structure for this domain