ProRule PRU00798

General rule information [?]

Accession PRU00798
Dates 20-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51465; KAZAL_2
Name Kazal domain
Function Kazal-type inhibitors represent the most studied canonical proteinase inhibitors.
Scope(s) Eukaryota
Example(s) P00995 (ISK1_HUMAN);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0010466; Biological process:negative regulation of peptidase activity
GO:0004867; Molecular function:serine-type endopeptidase inhibitor activity

Cross-references [?]

PROSITE PS00282; KAZAL_1; 1;

Features [?]

From: PS51465
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Kazal-like #"
SITE 15 16 /note="Reactive bond"
DISULFID 7 36 disulf C-x*-C
DISULFID 13 32 disulf C-x*-C
DISULFID 21 53 disulf C-x*-C

Additional information [?]

Size range 28-76 amino acids
Related rules None
Fusion None
Repeats 1-9
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]