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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00798


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00798
General rule information [?]

Accession PRU00798
Dates 20-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51465; KAZAL_2
Name Kazal domain
Function Kazal-type inhibitors represent the most studied canonical proteinase inhibitors.
Scope(s) Eukaryota
Metazoa
Example(s) P00995;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case
Protease inhibitor
Serine protease inhibitor

Gene Ontology [?]

GO:0010466; Biological process:negative regulation of peptidase activity
GO:0004867; Molecular function:serine-type endopeptidase inhibitor activity

Cross-references [?]

PROSITE PS00282; KAZAL_1; 1;

Features [?]

From: PS51465
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Kazal-like #"
SITE 15 16 /note="Reactive bond"
DISULFID 7 36 disulf C-x*-C
DISULFID 13 32 disulf C-x*-C
DISULFID 21 53 disulf C-x*-C

Additional information [?]

Size range 28-76 amino acids
Related rules None
Fusion None
Repeats 1-9
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]