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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00805


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00805
General rule information [?]

Accession PRU00805
Dates 08-DEC-2009 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51471; FE2OG_OXY
Name Fe(2+) 2-oxoglutarate dioxygenase domain
Function Enzymes with the Fe(2+) and 2-oxoglutarate (2OG)-dependent dioxygenase domain typically catalyse the oxidation of an organic substrate using a dioxygen molecule, mostly by using ferrous iron as the active site cofactor and 2OG as a cosubstrate which is decarboxylated to succinate and CO2.
Scope(s) Bacteria
Eukaryota
Viruses
Example(s) A1K320;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:2>
Protein name + RecName: EC=1.14.11.-;
else case <FTGroup:1>
Protein name + RecName: EC=1.14.-.-;
end case

Comments [?]

case <FTGroup:1>
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
end case

Keywords [?]

case <FTGroup:1>
Dioxygenase
Iron
Metal-binding
Oxidoreductase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
case <FTGroup:2>
GO:0016706; Molecular function:2-oxoglutarate-dependent dioxygenase activity
else case <FTGroup:1>
GO:0016705; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
end case

Features [?]

From: PS51471
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Fe2OG dioxygenase #"
BINDING 20 20 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 H 1
BINDING 20 20 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 H 2
BINDING 22 22 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 D 1
BINDING 22 22 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 D 2

Additional information [?]

Size range 80-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]