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General rule information [?]

Accession PRU00805
Dates 8-DEC-2009 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS51471; FE2OG_OXY
Names Fe(2+) 2-oxoglutarate dioxygenase domain; Fe(II) 2-oxoglutarate dioxygenase domain; PKHD (prolyl/lysyl hydroxylase) domain; P4Hc domain; 2-oxoglutarate and Fe(II)-dependent oxygenases; 2OG-Fe(II) oxygenase superfamily; 2OG oxygenase families
Function Enzymes with the Fe(2+) and 2-oxoglutarate (2OG)-dependent dioxygenase domain typically catalyse the oxidation of an organic substrate using a dioxygen molecule, mostly by using ferrous iron as the active site cofactor and 2OG as a cosubstrate which is decarboxylated to succinate and CO2.

Propagated annotation [?]

Description [?]

case <FTGroup:2>
+ RecName: EC 1.14.11.-;
else case <FTGroup:1>
+ RecName: EC 1.14.-.-;
end case

Comments [?]

case <FTGroup:1>
Cofactor Fe(2+)
Note: Binds 1 Fe(2+) ion per subunit.
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case

case <FTGroup:2>
GO:0016706; Molecular function: 2-oxoglutarate-dependent dioxygenase activity.
else case <FTGroup:1>
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
end case

Keywords [?]

case <FTGroup:1>
end case

Features [?]

From: PS51471
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Fe2OG dioxygenase #        
BINDING     20     20       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H   1,2
BINDING     22     22       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     D   1,2
BINDING     70     70       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875     H   1,2
BINDING     80     80       /ligand="2-oxoglutarate" /ligand_id="ChEBI:CHEBI:16810     [RK]   2

Additional information [?]

Size range 80-160 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A1K320 (Y608_AZOSB)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]