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ProRule PRU00805


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00805
Accession PRU00805
Dates 8-DEC-2009 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51471; FE2OG_OXY
Name Fe(2+) 2-oxoglutarate dioxygenase domain
Function Enzymes with the Fe(2+) and 2-oxoglutarate (2OG)-dependent dioxygenase domain typically catalyse the oxidation of an organic substrate using a dioxygen molecule, mostly by using ferrous iron as the active site cofactor and 2OG as a cosubstrate which is decarboxylated to succinate and CO2.
Scope(s) Bacteria
Eukaryota
Viruses
Example(s) A1K320 (Y608_AZOSB);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:2>
Protein name + RecName: EC=1.14.11.-;
else case <FTGroup:1>
Protein name + RecName: EC=1.14.-.-;
end case

Comments [?]

case <FTGroup:1>
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
end case

Keywords [?]

case <FTGroup:1>
Dioxygenase
Iron
Metal-binding
Oxidoreductase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
case <FTGroup:2>
GO:0016706; Molecular function:2-oxoglutarate-dependent dioxygenase activity
else case <FTGroup:1>
GO:0016705; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
end case

Features [?]

From: PS51471
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Fe2OG dioxygenase #"
BINDING 20 20 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 H 1
BINDING 20 20 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 H 2
BINDING 22 22 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 D 1
BINDING 22 22 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"		 D 2

Additional information [?]

Size range 80-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]