ProRule PRU00812

Accession	PRU00812
Dates	24-APR-2020 (Created) 19-NOV-2022 (Last updated, Version 4)
Data class	Domain;
Predictors	PROSITE; PS51479; ZF_RTR1
Name	RTR1-type zinc
Function	The eukaryotic protein family Rtr1/RPAP2 interacts with the C- terminal domain CTD of RNA polymerase II (RNAPII). It has been shown in yeast that Rtr1 is a CTD phosphatase that regulates RNAPII during the transition from serine 5 to serine 2 phosphorylation. Rtr1 proteins are poorly conserved overall, but they share a motif with three strictly conserved Cys residues and another residue conserved as His (in most fungi) or Cys (in animals and S. pombe), suggestive of a zinc finger motif (C-x(4)-C-x(n)-C-x(3)-[CH], where n ranges from 30 to 50).
Scope(s)	Eukaryota
Example(s)	F6RRD7 (RPAP2_BOVIN);

From: PS51479
Key	From	To	Description	Tag	Condition	FTGroup
case <Feature:PS51479:24=C> and <Feature:PS51479:29=C> and <Feature:PS51479:61=C> and <Feature:PS51479:65=[CH]>
ZN_FING	from	to	/note="RTR1-type #"
else case <Feature:PS51479:24=[CH]> and <Feature:PS51479:29=[CH]> and <Feature:PS51479:61=[CH]> and <Feature:PS51479:65=[CH]>
ZN_FING	from	to	/note="RTR1-type #; atypical"
else
ZN_FING	from	to	/note="RTR1-type #; degenerate"
end case
BINDING	24	24	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	29	29	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	61	61	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	65	65	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1