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annotation rule: PRU00812

General rule information [?]

Accession PRU00812
Dates 24-APR-2020 (Created)
16-MAR-2021 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51479; ZF_RTR1
Name RTR1-type zinc
Function The eukaryotic protein family Rtr1/RPAP2 interacts with the C- terminal domain CTD of RNA polymerase II (RNAPII). It has been shown in yeast that Rtr1 is a CTD phosphatase that regulates RNAPII during the transition from serine 5 to serine 2 phosphorylation. Rtr1 proteins are poorly conserved overall, but they share a motif with three strictly conserved Cys residues and another residue conserved as His (in most fungi) or Cys (in animals and S. pombe), suggestive of a zinc finger motif (C-x(4)-C-x(n)-C-x(3)-[CH], where n ranges from 30 to 50).

Propagated annotation [?]

Comments [?]

Similarity Belongs to the RPAP2 family.

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

case <Feature:PS51479:24=C> and <Feature:PS51479:29=C> and <Feature:PS51479:61=C> and <Feature:PS51479:65=[CH]>
From: PS51479
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       RTR1-type #        
else case <Feature:PS51479:24=[CH]> and <Feature:PS51479:29=[CH]> and <Feature:PS51479:61=[CH]> and <Feature:PS51479:65=[CH]>
ZN_FING     from     to       RTR1-type #; atypical        
ZN_FING     from     to       RTR1-type #; degenerate        
end case

METAL     24     24       Zinc #1     [CH]   1
METAL     29     29       Zinc #1     [CH]   1
METAL     61     61       Zinc #1     [CH]   1
METAL     65     65       Zinc #1     [CH]   1

Additional information [?]

Size range 70-90 amino acids
Related rules None
Repeats 1
Topology Undefined
Example F6RRD7 (RPAP2_BOVIN)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]