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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00812


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00812
General rule information [?]

Accession PRU00812
Dates 24-APR-2020 (Created)
19-NOV-2022 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51479; ZF_RTR1
Name RTR1-type zinc
Function The eukaryotic protein family Rtr1/RPAP2 interacts with the C- terminal domain CTD of RNA polymerase II (RNAPII). It has been shown in yeast that Rtr1 is a CTD phosphatase that regulates RNAPII during the transition from serine 5 to serine 2 phosphorylation. Rtr1 proteins are poorly conserved overall, but they share a motif with three strictly conserved Cys residues and another residue conserved as His (in most fungi) or Cys (in animals and S. pombe), suggestive of a zinc finger motif (C-x(4)-C-x(n)-C-x(3)-[CH], where n ranges from 30 to 50).
Scope(s) Eukaryota
Example(s) F6RRD7;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the RPAP2 family.

Keywords [?]

Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51479
Key From To Description Tag Condition FTGroup
case <Feature:PS51479:24=C> and <Feature:PS51479:29=C> and <Feature:PS51479:61=C> and <Feature:PS51479:65=[CH]>
ZN_FING from to /note="RTR1-type #"
else case <Feature:PS51479:24=[CH]> and <Feature:PS51479:29=[CH]> and <Feature:PS51479:61=[CH]> and <Feature:PS51479:65=[CH]>
ZN_FING from to /note="RTR1-type #; atypical"
else
ZN_FING from to /note="RTR1-type #; degenerate"
end case
BINDING 24 24 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 61 61 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 65 65 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 70-90 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]