ProRule PRU00812

General rule information [?]

Accession PRU00812
Dates 24-APR-2020 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51479; ZF_RTR1
Name RTR1-type zinc
Function The eukaryotic protein family Rtr1/RPAP2 interacts with the C- terminal domain CTD of RNA polymerase II (RNAPII). It has been shown in yeast that Rtr1 is a CTD phosphatase that regulates RNAPII during the transition from serine 5 to serine 2 phosphorylation. Rtr1 proteins are poorly conserved overall, but they share a motif with three strictly conserved Cys residues and another residue conserved as His (in most fungi) or Cys (in animals and S. pombe), suggestive of a zinc finger motif (C-x(4)-C-x(n)-C-x(3)-[CH], where n ranges from 30 to 50).
Scope(s) Eukaryota
Example(s) F6RRD7 (RPAP2_BOVIN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the RPAP2 family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51479
Key From To Description Tag Condition FTGroup
case <Feature:PS51479:24=C> and <Feature:PS51479:29=C> and <Feature:PS51479:61=C> and <Feature:PS51479:65=[CH]>
ZN_FING from to /note="RTR1-type #"
else case <Feature:PS51479:24=[CH]> and <Feature:PS51479:29=[CH]> and <Feature:PS51479:61=[CH]> and <Feature:PS51479:65=[CH]>
ZN_FING from to /note="RTR1-type #; atypical"
ZN_FING from to /note="RTR1-type #; degenerate"
end case
BINDING 24 24 /ligand="Zn(2+)"
[CH] 1
BINDING 29 29 /ligand="Zn(2+)"
[CH] 1
BINDING 61 61 /ligand="Zn(2+)"
[CH] 1
BINDING 65 65 /ligand="Zn(2+)"
[CH] 1

Additional information [?]

Size range 70-90 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]