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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00834


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00834
General rule information [?]

Accession PRU00834
Dates 08-DEC-2010 (Created)
19-NOV-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51501; ZF_DNL
Name Zinc finger DNL-type
Function Tim15 contains a zinc-finger motif (CXXC and CXXC) of ~100 residues, which has been named DNL after a short C-terminal motif of D(N/H)L.
Scope(s) Eukaryota
Example(s) B5VQB0;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS51501:12=[CH]> and <Feature:PS51501:15=[CH]> and <Feature:PS51501:37=[CH]> and <Feature:PS51501:40=[CH]>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51501
Key From To Description Tag Condition FTGroup
case <Feature:PS51501:12=C> and <Feature:PS51501:15=C> and <Feature:PS51501:37=C> and <Feature:PS51501:40=C>
ZN_FING 1 98 /note="DNL-type"
else case <Feature:PS51501:12=[CH]> and <Feature:PS51501:15=[CH]> and <Feature:PS51501:37=[CH]> and <Feature:PS51501:40=[CH]>
ZN_FING from to /note="DNL-type #; atypical"
else
ZN_FING from to /note="DNL-type #; degenerate"
end case
BINDING 12 12 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 15 15 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 86-108 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]