We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00839
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00839
General rule information
[?]
| Accession | PRU00839 |
| Dates | 31-AUG-2010 (Created)
19-NOV-2022 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51506; CBL_PTB |
Name | Cbl-type phosphotyrosine-binding (Cbl-PTB) domain |
| Function | Cbl-PTB is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The three domains together form an integrated phosphoprotein-recognition module. |
| Scope(s) |
Eukaryota Viruses Murine leukemia virus |
| Example(s) | Q557E7; |
Propagated annotation
[?]
Comments
[?]
| DOMAIN | The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. |
Keywords
[?]
Gene Ontology
[?]
| GO:0005509; Molecular function:calcium ion binding |
| GO:0007166; Biological process:cell surface receptor signaling pathway |
Features
[?]
| From: PS51506 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Cbl-PTB #" | |||||||||
| REGION | from | 131 | /note="4H #" | |||||||||
| REGION | 132 | 204 | /note="EF-hand-like #" | |||||||||
| REGION | 205 | to | /note="SH2-like #" | |||||||||
| case <Feature:PS51506:185-197=D-{W}-[DNST]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW]> | ||||||||||||
| BINDING | 185 | 185 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
binds | [HCUEDKQNMYWSTRX] | |||||||
| BINDING | 187 | 187 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
binds | [HCUEDKQNMYWSTRX] | |||||||
| BINDING | 189 | 189 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
binds | [HCUEDKQNMYWSTRX] | |||||||
| BINDING | 191 | 191 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
binds | [HCUEDKQNMYWSTRX] | |||||||
| BINDING | 196 | 196 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="#1" |
binds | [HCUEDKQNMYWSTRX] | |||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 282-325 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [12] Viruses [1] All [ 13 ]
- Retrieve set of proteins with 3D structure for this domain