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annotation rule: PRU00839

General rule information [?]

Accession PRU00839
Dates 31-AUG-2010 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51506; CBL_PTB
Names Cbl-type phosphotyrosine-binding (Cbl-PTB) domain; Cbl N-terminal (Cbl-N) domain; Tyrosine kinase binding (TKB) domain
Function Cbl-PTB is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The three domains together form an integrated phosphoprotein-recognition module.

Propagated annotation [?]

Comments [?]

Domain The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

Gene Ontology [?]

GO:0005509; Molecular function: calcium ion binding.
GO:0007166; Biological process: cell surface receptor signaling pathway.

Keywords [?]

Features [?]

From: PS51506
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Cbl-PTB #        
REGION     from     131       4H #        
REGION     132     204       EF-hand-like #        
REGION     205     to       SH2-like #        
CA_BIND     183     194       #        

Additional information [?]

Size range 282-325 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q557E7 (CBLA_DICDI)
Viruses; Murine leukemia virus
Comments None


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UniProtKB rule member sequences [?]