ProRule PRU00839

General rule information [?]

Accession	PRU00839
Dates	31-AUG-2010 (Created) 19-NOV-2022 (Last updated, Version 10)
Data class	Domain;
Predictors	PROSITE; PS51506; CBL_PTB
Name	Cbl-type phosphotyrosine-binding (Cbl-PTB) domain
Function	Cbl-PTB is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The three domains together form an integrated phosphoprotein-recognition module.
Scope(s)	Eukaryota Viruses Murine leukemia virus
Example(s)	Q557E7 (CBLA_DICDI);

Propagated annotation [?]

Comments [?]

DOMAIN

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

Keywords [?]

Calcium

Metal-binding

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding

GO:0007166; Biological process:cell surface receptor signaling pathway

Features [?]

From: PS51506

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="Cbl-PTB #"

REGION

from

131

/note="4H #"

REGION

132

204

/note="EF-hand-like #"

REGION

205

/note="SH2-like #"

case <Feature:PS51506:185-197=D-{W}-[DNST]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW]>

BINDING

185