ProRule PRU00839

General rule information [?]

Accession PRU00839
Dates 31-AUG-2010 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51506; CBL_PTB
Name Cbl-type phosphotyrosine-binding (Cbl-PTB) domain
Function Cbl-PTB is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The three domains together form an integrated phosphoprotein-recognition module.
Scope(s) Eukaryota
Murine leukemia virus
Example(s) Q557E7 (CBLA_DICDI);

Propagated annotation [?]

Comments [?]

DOMAINThe N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

Keywords [?]

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding
GO:0007166; Biological process:cell surface receptor signaling pathway

Features [?]

From: PS51506
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Cbl-PTB #"
REGION from 131 /note="4H #"
REGION 132 204 /note="EF-hand-like #"
REGION 205 to /note="SH2-like #"
case <Feature:PS51506:185-197=D-{W}-[DNST]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW]>
BINDING 185 185 /ligand="Ca(2+)"
BINDING 187 187 /ligand="Ca(2+)"
BINDING 189 189 /ligand="Ca(2+)"
BINDING 191 191 /ligand="Ca(2+)"
BINDING 196 196 /ligand="Ca(2+)"
end case

Additional information [?]

Size range 282-325 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]