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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00855


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00855
General rule information [?]

Accession PRU00855
Dates 04-FEB-2011 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51522; ZF_NANOS
Name Zinc finger nanos-type
Function The nanos-type zinc finger has two conserved Cys-Cys-His-Cys (CCHC)- type zinc-finger motifs that are indispensable for nanos function.
Scope(s) Eukaryota
Metazoa
Example(s) P60323;

Propagated annotation [?]

Comments [?]

case <Feature:PS51522:2=C> and <Feature:PS51522:5=C> and <Feature:PS51522:18=H> and <Feature:PS51522:29=C> and <Feature:PS51522:37=C> and <Feature:PS51522:40=C> and <Feature:PS51522:48=H> and <Feature:PS51522:53=C>
DOMAINThe Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
end case
SIMILARITYBelongs to the nanos family.

Keywords [?]

Metal-binding
Zinc
end case
RNA-binding
Translation regulation
Zinc-finger

Gene Ontology [?]

GO:0006417; Biological process:regulation of translation
GO:0003723; Molecular function:RNA binding
case (<Feature:PS51522:2=CH> and <Feature:PS51522:5=CH> and <Feature:PS51522:18=HC> and <Feature:PS51522:29=CH>) or (<Feature:PS51522:37=CH> and <Feature:PS51522:40=CH> and <Feature:PS51522:48=HC> and <Feature:PS51522:53=CH>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51522
Key From To Description Tag Condition FTGroup
case (<Feature:PS51522:2=C> and <Feature:PS51522:5=C> and <Feature:PS51522:18=H> and <Feature:PS51522:29=C>) and (<Feature:PS51522:37=C> and <Feature:PS51522:40=C> and <Feature:PS51522:48=H> and <Feature:PS51522:53=C>)
ZN_FING from to /note="Nanos-type #"
else case (<Feature:PS51522:2=[CH]> and <Feature:PS51522:5=[CH]> and <Feature:PS51522:18=[HC]> and <Feature:PS51522:29=[CH]>) and (<Feature:PS51522:37=[CH]> and <Feature:PS51522:40=[CH]> and <Feature:PS51522:48=[HC]> and <Feature:PS51522:53=[CH]>)
ZN_FING from to /note="Nanos-type #; atypical"
else
ZN_FING from to /note="Nanos-type #; degenerate"
end case
case <FTGroup:1>
MOTIF 2 29 /note="C2HC #1"
end case
case <FTGroup:2>
MOTIF 37 53 /note="C2HC #2"
end case
BINDING 2 2 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 48 48 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 53 53 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 45-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]