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ProRule PRU00855


General rule information [?]

Accession PRU00855
Dates 4-FEB-2011 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51522; ZF_NANOS
Name Zinc finger nanos-type
Function The nanos-type zinc finger has two conserved Cys-Cys-His-Cys (CCHC)- type zinc-finger motifs that are indispensable for nanos function.
Scope(s) Eukaryota
Metazoa
Example(s) P60323 (NANO3_HUMAN);

Propagated annotation [?]

Comments [?]

case <Feature:PS51522:2=C> and <Feature:PS51522:5=C> and <Feature:PS51522:18=H> and <Feature:PS51522:29=C> and <Feature:PS51522:37=C> and <Feature:PS51522:40=C> and <Feature:PS51522:48=H> and <Feature:PS51522:53=C>
DOMAINThe Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
end case
SIMILARITYBelongs to the nanos family.

Keywords [?]


Gene Ontology [?]

GO:0006417; Biological process:regulation of translation
GO:0003723; Molecular function:RNA binding
case (<Feature:PS51522:2=CH> and <Feature:PS51522:5=CH> and <Feature:PS51522:18=HC> and <Feature:PS51522:29=CH>) or (<Feature:PS51522:37=CH> and <Feature:PS51522:40=CH> and <Feature:PS51522:48=HC> and <Feature:PS51522:53=CH>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51522
Key From To Description Tag Condition FTGroup
case (<Feature:PS51522:2=C> and <Feature:PS51522:5=C> and <Feature:PS51522:18=H> and <Feature:PS51522:29=C>) and (<Feature:PS51522:37=C> and <Feature:PS51522:40=C> and <Feature:PS51522:48=H> and <Feature:PS51522:53=C>)
ZN_FING from to /note="Nanos-type #"
else case (<Feature:PS51522:2=[CH]> and <Feature:PS51522:5=[CH]> and <Feature:PS51522:18=[HC]> and <Feature:PS51522:29=[CH]>) and (<Feature:PS51522:37=[CH]> and <Feature:PS51522:40=[CH]> and <Feature:PS51522:48=[HC]> and <Feature:PS51522:53=[CH]>)
ZN_FING from to /note="Nanos-type #; atypical"
else
ZN_FING from to /note="Nanos-type #; degenerate"
end case
case <FTGroup:1>
MOTIF 2 29 /note="C2HC #1"
end case
case <FTGroup:2>
MOTIF 37 53 /note="C2HC #2"
end case
BINDING 2 2 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
[CH] 1
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 48 48 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2
BINDING 53 53 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
[CH] 2

Additional information [?]

Size range 45-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]