ProRule PRU00855

PURL	https://purl.expasy.org/prosite/rule/PRU00855
Accession	PRU00855
Dates	4-FEB-2011 (Created) 19-NOV-2022 (Last updated, Version 9)
Data class	Domain;
Predictors	PROSITE; PS51522; ZF_NANOS
Name	Zinc finger nanos-type
Function	The nanos-type zinc finger has two conserved Cys-Cys-His-Cys (CCHC)- type zinc-finger motifs that are indispensable for nanos function.
Scope(s)	Eukaryota Metazoa
Example(s)	P60323 (NANO3_HUMAN);

From: PS51522
Key	From	To	Description	Tag	Condition	FTGroup
case (<Feature:PS51522:2=C> and <Feature:PS51522:5=C> and <Feature:PS51522:18=H> and <Feature:PS51522:29=C>) and (<Feature:PS51522:37=C> and <Feature:PS51522:40=C> and <Feature:PS51522:48=H> and <Feature:PS51522:53=C>)
ZN_FING	from	to	/note="Nanos-type #"
else case (<Feature:PS51522:2=[CH]> and <Feature:PS51522:5=[CH]> and <Feature:PS51522:18=[HC]> and <Feature:PS51522:29=[CH]>) and (<Feature:PS51522:37=[CH]> and <Feature:PS51522:40=[CH]> and <Feature:PS51522:48=[HC]> and <Feature:PS51522:53=[CH]>)
ZN_FING	from	to	/note="Nanos-type #; atypical"
else
ZN_FING	from	to	/note="Nanos-type #; degenerate"
end case
case <FTGroup:1>
MOTIF	2	29	/note="C2HC #1"
end case
case <FTGroup:2>
MOTIF	37	53	/note="C2HC #2"
end case
BINDING	2	2	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	5	5	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	18	18	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	29	29	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	37	37	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	40	40	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	48	48	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	53	53	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2