PRU00863
General rule information
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| Accession | PRU00863 |
| Dates | 10-AUG-2011 (Created) 21-NOV-2019 (Last updated, Version 7) |
| Data class | Domain |
| Predictors | PROSITE; PS51531; FV_PR |
| Name | Foamy virus protease (FV PR) domain |
| Function | The FV PR domain forms peptidase family A9 (spumapepsin family). Retrovriral PRs belong to the family of aspartic proteases and are active as homodimers, with the active site triplets (Asp-Thr/Ser-Gly; D-T/S-G) from both chain contributing to the symetric active site of the enzyme. |
Propagated annotation
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Comments
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case <FT:2>
| Subunit | The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. |
Gene Ontology
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GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
Keywords
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end case
Features
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| From: PS51531 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase A9 # | |||||||||
| ACT_SITE | 21 | 21 | For protease activity | D | ||||||||
Additional information
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| Size range | 130-153 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P14350 (POL_FOAMV) |
| Scope | Viruses; Spumavirus |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [5]
- Retrieve set of proteins with 3D structure for this domain