PRU00863
General rule information
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Accession | PRU00863 |
Dates | 10-AUG-2011 (Created) 21-NOV-2019 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51531; FV_PR |
Name | Foamy virus protease (FV PR) domain |
Function | The FV PR domain forms peptidase family A9 (spumapepsin family). Retrovriral PRs belong to the family of aspartic proteases and are active as homodimers, with the active site triplets (Asp-Thr/Ser-Gly; D-T/S-G) from both chain contributing to the symetric active site of the enzyme. |
Propagated annotation
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Comments
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case <FT:2>
Subunit | The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. |
Gene Ontology
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GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
Keywords
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end case
Features
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From: PS51531 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase A9 # | |||||||||
ACT_SITE | 21 | 21 | For protease activity | D |
Additional information
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Size range | 130-153 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P14350 (POL_FOAMV) |
Scope | Viruses; Spumavirus |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Viruses [5]
- Retrieve set of proteins with 3D structure for this domain