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annotation rule: PRU00863

General rule information [?]

Accession PRU00863
Dates 10-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51531; FV_PR
Name Foamy virus protease (FV PR) domain
Function The FV PR domain forms peptidase family A9 (spumapepsin family). Retrovriral PRs belong to the family of aspartic proteases and are active as homodimers, with the active site triplets (Asp-Thr/Ser-Gly; D-T/S-G) from both chain contributing to the symetric active site of the enzyme.

Propagated annotation [?]


Comments [?]

case <FT:2>
Subunit The protease is a homodimer, whose active site consists of two apposed aspartic acid residues.

Gene Ontology [?]

GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.

Keywords [?]

end case


Features [?]

From: PS51531
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase A9 #        
ACT_SITE     21     21       For protease activity     D  

Additional information [?]

Size range 130-153 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P14350 (POL_FOAMV)
Scope
Viruses; Spumavirus
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]