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General rule information [?]

Accession PRU00867
Dates 10-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51534; SEFIR
Name SEFIR domain
Function The SEFIR domain (after SEFs and IL17Rs) is a conserved sequence segment identified in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria. It is related to the TIR domain. The similarity between the SEFIR and TIR domains involves the conserved boxes 1 and 2 of the TIR domain that are implicated in homotypic dimerization, but there is no sequence similarity between SEFIR domains and the TIR sequence box 3.

Propagated annotation [?]

Features [?]

From: PS51534
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       SEFIR #        

Additional information [?]

Size range 127-175 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q8QHJ9 (I17RD_DANRE)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]