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ProRule PRU00867
General rule information
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| Accession | PRU00867 |
| Dates | 10-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51534; SEFIR |
Name | SEFIR domain |
| Function | The SEFIR domain (after SEFs and IL17Rs) is a conserved sequence segment identified in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria. It is related to the TIR domain. The similarity between the SEFIR and TIR domains involves the conserved boxes 1 and 2 of the TIR domain that are implicated in homotypic dimerization, but there is no sequence similarity between SEFIR domains and the TIR sequence box 3. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q8QHJ9 (I17RD_DANRE); |
Propagated annotation
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Features
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| From: PS51534 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="SEFIR #" | |||||||||
Additional information
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| Size range | 127-175 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [17] All [ 17 ]
- Retrieve set of proteins with 3D structure for this domain