ProRule PRU00867

General rule information [?]

Accession PRU00867
Dates 10-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51534; SEFIR
Name SEFIR domain
Function The SEFIR domain (after SEFs and IL17Rs) is a conserved sequence segment identified in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria. It is related to the TIR domain. The similarity between the SEFIR and TIR domains involves the conserved boxes 1 and 2 of the TIR domain that are implicated in homotypic dimerization, but there is no sequence similarity between SEFIR domains and the TIR sequence box 3.
Scope(s) Eukaryota
Example(s) Q8QHJ9 (I17RD_DANRE);

Propagated annotation [?]

Features [?]

From: PS51534
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SEFIR #"

Additional information [?]

Size range 127-175 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]