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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00871


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00871
General rule information [?]

Accession PRU00871
Dates 08-AUG-2011 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51538; AV_CP
Name Arterivirus nsp2 cysteine protease (AV CP) domain
Function The AV CP is an unusual Cys protease with amino acid sequence similarities to both papain-like and chymotrypsin-like proteases. The catalytic dyad is composed of Cys and His residues. The AV CP domain forms peptidase family C33.
Scope(s) Viruses
Arteriviridae
Example(s) Q9YN02;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008234; Molecular function:cysteine-type peptidase activity
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0019082; Biological process:viral protein processing

Features [?]

From: PS51538
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C33 #"
ACT_SITE 10 10 /note="For Nsp2 cysteine proteinase activity" C 1
ACT_SITE 79 79 /note="For Nsp2 cysteine proteinase activity" H 1

Additional information [?]

Size range 90-118 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]