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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00872


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00872
General rule information [?]

Accession PRU00872
Dates 31-MAY-2011 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51539; AV_PCP_ALPHA
Name Arterivirus papain-like cysteine protease alpha (PCPalpha) domain
Function The PCPalpha domain mediates the nsp1alpha|1beta cleavage.
Scope(s) Viruses
Arteriviridae
Example(s) Q9YN02;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51539
Key From To Description Tag Condition FTGroup
case <FTGroup:1>
DOMAIN from to /note="Peptidase C31 #"
else
DOMAIN from to /note="Peptidase C31 (inactive) #"
end case
ACT_SITE 8 8 /note="For Nsp1-alpha papain-like cysteine proteinase activity" C 1
ACT_SITE 77 77 /note="For Nsp1-alpha papain-like cysteine proteinase activity" H 1
case <FTGroup:1>
SITE to to+1 /note="Cleavage; by autolysis"
end case

Additional information [?]

Size range 81-123 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]