We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00873
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00873
General rule information
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| Accession | PRU00873 |
| Dates | 31-MAY-2011 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51540; AV_PCP_BETA |
Name | Arterivirus papain-like cysteine protease beta (PCPbeta) domain |
| Function | The PCPbeta domain mediates the nsp1beta|2 cleavage. |
| Scope(s) |
Viruses Arteriviridae |
| Example(s) | Q9YN02; |
Propagated annotation
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Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0008233; Molecular function:peptidase activity | |
| GO:0004197; Molecular function:cysteine-type endopeptidase activity | |
Features
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| From: PS51540 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <FTGroup:1> | ||||||||||||
| DOMAIN | from | to | /note="Peptidase C32 #" | |||||||||
| else | ||||||||||||
| DOMAIN | from | to | /note="Peptidase C32 (inactive) #" | |||||||||
| end case | ||||||||||||
| ACT_SITE | 8 | 8 | /note="For Nsp1-beta papain-like cysteine proteinase activity" | C | 1 | |||||||
| ACT_SITE | 73 | 73 | /note="For Nsp1-beta papain-like cysteine proteinase activity" | H | 1 | |||||||
| case <FTGroup:1> and <Feature:PS51540:113=Y> | ||||||||||||
| SITE | to | to+1 | /note="Cleavage; by autolysis" | G-[GA] | ||||||||
| else case <FTGroup:1> | ||||||||||||
| SITE | to | to+1 | /note="Cleavage; by autolysis" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 94-131 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [12] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain