PRU00894
General rule information
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| Accession | PRU00894 |
| Dates | 25-NOV-2011 (Created) 19-NOV-2022 (Last updated, Version 14) |
| Data class | Domain |
case <Length>=211> and <Length<=317>
| Predictors | PROSITE; PS51561; SAM_NNMT_PNMT_TEMT_1 |
end case
| Name | Nicotinamide N-methyltransferase (EC 2.1.1.1) |
| Function | Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.1; |
Comments
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| Catalytic activity | RHEA:23884: nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine
EC 2.1.1.1 |
| Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Gene Ontology
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GO:0008112; Molecular function: nicotinamide N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Features
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| From: PS51561 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 63 | 64 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | |||||||||
| BINDING | 142 | 143 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | |||||||||
| BINDING | 20 | 20 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 25 | 25 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 69 | 69 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Y | ||||||||
| BINDING | 85 | 85 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | ||||||||
| BINDING | 90 | 90 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | N | ||||||||
| BINDING | 163 | 163 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [AFLT] | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q06AV1 (NNMT_PIG) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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