ProRule PRU00894
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00894 |
| Accession | PRU00894 |
| Dates | 25-NOV-2011 (Created)
19-NOV-2022 (Last updated, Version 14) |
| Data class | Domain; |
| Predictors |
case c? <Length>=211> and <Length<=317>
PROSITE; PS51561; SAM_NNMT_PNMT_TEMT_1 end case
|
Name | Nicotinamide N-methyltransferase (EC 2.1.1.1) |
| Function | Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q06AV1 (NNMT_PIG); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Keywords
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Gene Ontology
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| GO:0008112; Molecular function:nicotinamide N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51561 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 63 | 64 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| BINDING | 142 | 143 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| BINDING | 20 | 20 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 25 | 25 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 69 | 69 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 85 | 85 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 90 | 90 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
| BINDING | 163 | 163 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[AFLT] | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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