ProRule PRU00894
General rule information
[?]
Accession | PRU00894 |
Dates | 25-NOV-2011 (Created)
19-NOV-2022 (Last updated, Version 14) |
Data class | Domain; |
Predictors |
case c? <Length>=211> and <Length<=317>
PROSITE; PS51561; SAM_NNMT_PNMT_TEMT_1 end case
|
Name | Nicotinamide N-methyltransferase (EC 2.1.1.1) |
Function | Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine. |
Scope(s) |
Eukaryota Metazoa |
Example(s) | Q06AV1 (NNMT_PIG); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name | + RecName: EC=2.1.1.1; |
Comments
[?]
CATALYTIC ACTIVITY | Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1; |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Keywords
[?]
Gene Ontology
[?]
GO:0008112; Molecular function:nicotinamide N-methyltransferase activity |
GO:0032259; Biological process:methylation |
GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
[?]
From: PS51561 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 63 | 64 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
BINDING | 142 | 143 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
BINDING | 20 | 20 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 25 | 25 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 69 | 69 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
BINDING | 85 | 85 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 90 | 90 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
BINDING | 163 | 163 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[AFLT] |
Additional information
[?]
Size range | unlimited amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.