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annotation rule: PRU00894

General rule information [?]

Accession PRU00894
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain
case <Length>=211> and <Length<=317>
Predictors PROSITE; PS51561; SAM_NNMT_PNMT_TEMT_1
end case

Name Nicotinamide N-methyltransferase (EC 2.1.1.1)
Function Nicotinamide N-methyltransferase (EC 2.1.1.1) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide to form 1-methylnicotinamide and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.1;

Comments [?]

Catalytic activity RHEA:23884: nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine
EC 2.1.1.1
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

Gene Ontology [?]

GO:0008112; Molecular function: nicotinamide N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51561
Key     From     To       Description   Tag   Condition   FTGroup
REGION     63     64       S-adenosyl-L-methionine binding        
REGION     142     143       S-adenosyl-L-methionine binding        
BINDING     20     20       S-adenosyl-L-methionine     Y  
BINDING     25     25       S-adenosyl-L-methionine     Y  
BINDING     69     69       S-adenosyl-L-methionine     Y  
BINDING     85     85       S-adenosyl-L-methionine     D  
BINDING     90     90       S-adenosyl-L-methionine     N  
BINDING     163     163       S-adenosyl-L-methionine; via carbonyl oxygen     [AFLT]  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q06AV1 (NNMT_PIG)
Scope
Eukaryota; Metazoa
Comments None

Copyright

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