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ProRule PRU00896


General rule information [?]

Accession PRU00896
Dates 25-NOV-2011 (Created)
25-APR-2024 (Last updated, Version 12)
Data class Domain;
Predictors
case c? <Length>=464> and <Length<=696>
PROSITE; PS51563; SAM_MTA70L_1
end case
Name N6-adenosine-methyltransferase catalytic subunit (EC=2.1.1.348)
Function The N6-methyltransferase complex methylates adenosine residues at the N(6) position of some RNAs.
Scope(s) Eukaryota
Example(s) F1R777 (MTA70_DANRE);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.348;

Comments [?]

CATALYTIC ACTIVITY Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)- methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MT-A70-like family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
GO:0016422; Molecular function:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0001734; Molecular function:mRNA m(6)A methyltransferase activity
GO:0032259; Biological process:methylation
GO:0001510; Biological process:RNA methylation

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]