ProRule PRU00896
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00896 |
| Accession | PRU00896 |
| Dates | 25-NOV-2011 (Created)
3-SEP-2024 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
case c? <Length>=464> and <Length<=696>
PROSITE; PS51563; SAM_MTA70L_1 end case
|
Name | N6-adenosine-methyltransferase catalytic subunit (EC=2.1.1.348) |
| Function | The N6-methyltransferase complex methylates adenosine residues at the N(6) position of some RNAs. |
| Scope(s) |
Eukaryota |
| Example(s) | F1R777 (MTA70_DANRE); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.348; |
Comments
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| CATALYTIC ACTIVITY | Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)- methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. MT-A70-like family. |
Keywords
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Gene Ontology
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| GO:0003723; Molecular function:RNA binding |
| GO:0016422; Molecular function:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity |
| GO:0001734; Molecular function:mRNA m(6)A methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0001510; Biological process:RNA methylation |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [4] All [ 4 ]
- Retrieve set of proteins with 3D structure for this domain