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annotation rule: PRU00896

General rule information [?]

Accession PRU00896
Dates 25-NOV-2011 (Created)
14-JUN-2019 (Last updated, Version 9)
Data class Domain
case <Length>=464> and <Length<=696>
Predictors PROSITE; PS51563; SAM_MTA70L_1
end case

Names N6-adenosine-methyltransferase catalytic subunit (EC=2.1.1.348); N6-adenosine-methyltransferase 70 kDa subunit (MT-A70)
Function The N6-methyltransferase complex methylates adenosine residues at the N(6) position of some RNAs.

Propagated annotation [?]


Description [?]

+ RecName: EC=2.1.1.348;

Comments [?]

Catalytic activity Reaction=adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. MT-A70-like family.

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0016422; Molecular function: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity.
GO:0001734; Molecular function: mRNA (N6-adenosine)-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0001510; Biological process: RNA methylation.

Keywords [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example F1R777 (MTA70_DANRE)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [1]