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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00896


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00896
General rule information [?]

Accession PRU00896
Dates 25-NOV-2011 (Created)
03-SEP-2024 (Last updated, Version 14)
Data class Domain;
Predictors
case c? <Length>=464> and <Length<=696>
PROSITE; PS51563; SAM_MTA70L_1
end case
Name N6-adenosine-methyltransferase catalytic subunit (EC=2.1.1.348)
Function The N6-methyltransferase complex methylates adenosine residues at the N(6) position of some RNAs.
Scope(s) Eukaryota
Example(s) F1R777;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.348;

Comments [?]

CATALYTIC ACTIVITY Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)- methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MT-A70-like family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
GO:0016422; Molecular function:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0001734; Molecular function:mRNA m(6)A methyltransferase activity
GO:0032259; Biological process:methylation
GO:0001510; Biological process:RNA methylation

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]