PRU00897
General rule information
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Accession | PRU00897 |
Dates | 25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 8) |
Data class | Domain |
case <Length>=242> and <Length<=362>
Predictors | PROSITE; PS51564; SAM_ICMT |
end case
Name | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) |
Function | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.100; |
Comments
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Catalytic activity | RHEA:21672: [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine
EC 2.1.1.100 |
Similarity | Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. |
Gene Ontology
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GO:0004671; Molecular function: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | O60725 (ICMT_HUMAN) |
Scope | Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [12]
- Retrieve set of proteins with 3D structure for this domain