ProRule PRU00897

General rule information [?]

Accession PRU00897
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain;
case c? <Length>=242> and <Length<=362>
end case
Name Protein-S-isoprenylcysteine O-methyltransferase (EC
Function Protein-S-isoprenylcysteine O-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Example(s) O60725 (ICMT_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S- adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L- cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=;
SIMILARITYBelongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0004671; Molecular function:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]