PRU00897

General rule information [?]

Accession	PRU00897
Dates	25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 8)

Data class

Domain

case <Length>=242> and <Length<=362>

Predictors

PROSITE; PS51564; SAM_ICMT

end case

Name	Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100)

Function

Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC 2.1.1.100;

Comments [?]

Catalytic activity	RHEA:21672: [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine EC 2.1.1.100
Similarity	Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Gene Ontology [?]

GO:0004671; Molecular function: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Additional information [?]

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	O60725 (ICMT_HUMAN)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [12]
Retrieve set of proteins with 3D structure for this domain