ProRule PRU00897
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00897 |
| Accession | PRU00897 |
| Dates | 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
case c? <Length>=242> and <Length<=362>
PROSITE; PS51564; SAM_ICMT end case
|
Name | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) |
| Function | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | O60725 (ICMT_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.100; |
Comments
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| CATALYTIC ACTIVITY | Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S- adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L- cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100; |
| SIMILARITY | Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. |
Keywords
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Gene Ontology
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| GO:0004671; Molecular function:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [12] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain