General rule information
27-OCT-2018 (Last updated, Version 7)
case <Length>=242> and <Length<=362>
||PROSITE; PS51564; SAM_ICMT
||Protein-S-isoprenylcysteine O-methyltransferase (EC 220.127.116.11) |
|| Protein-S-isoprenylcysteine O-methyltransferase (EC 18.104.22.168) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine. |
|| Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S- adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)- farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA- COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=22.214.171.124;.
||Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
; Molecular function: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
; Biological process: methylation.
; Biological process: S-adenosylmethionine metabolic process.
||unlimited amino acids
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(CC BY-NC-ND 4.0) License, see prosite_license.html
UniProtKB rule member sequences