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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00897


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PURL: https://purl.expasy.org/prosite/rule/PRU00897
General rule information [?]

Accession PRU00897
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 9)
Data class Domain;
Predictors
case c? <Length>=242> and <Length<=362>
PROSITE; PS51564; SAM_ICMT
end case
Name Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100)
Function Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to a protein C-terminal S-farnesyl-L-cysteine to form a protein C-terminal S- farnesyl-L-cysteine methyl ester and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Example(s) O60725;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.100;

Comments [?]

CATALYTIC ACTIVITY Reaction=[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S- adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L- cysteine methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:21672, Rhea:RHEA-COMP:12125, Rhea:RHEA-COMP:12126, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90510, ChEBI:CHEBI:90511; EC=2.1.1.100;
SIMILARITYBelongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0004671; Molecular function:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]