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annotation rule: PRU00898

General rule information [?]

Accession PRU00898
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain
Predictors PROSITE; PS51565; SAM_MT85_SETD3
Name SETD3 actin-histidine N-methyltransferase (EC
Function SETD3 Actin-histidine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-histidine-[actin] to form N(tele)-methyl-L-histidine-[actin] and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:19369: L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
PhysiologicalDirection=left-to-right (RHEA:19370)
Similarity Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.

Gene Ontology [?]

GO:0018021; Biological process: peptidyl-histidine methylation.
GO:0030047; Biological process: actin modification.

Keywords [?]

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q86TU7 (SETD3_HUMAN)
Comments None


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UniProtKB rule member sequences [?]