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| annotation rule: PRU00898 |
General rule information
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| Accession | PRU00898 |
| Dates | 25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 14) |
| Data class | Domain |
| Predictors | PROSITE; PS51565; SAM_MT85_SETD3 |
| Name | SETD3 actin-histidine N-methyltransferase (EC 2.1.1.85) |
| Function | SETD3 Actin-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-histidine-[actin] to form N(tele)-methyl-L-histidine-[actin] and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.85; |
Comments
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| Catalytic activity | RHEA:19369: L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
EC 2.1.1.85 PhysiologicalDirection=left-to-right (RHEA:19370) |
| Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. |
Gene Ontology
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GO:0018021; Biological process: peptidyl-histidine methylation.
GO:0030047; Biological process: actin modification.
GO:0030047; Biological process: actin modification.
Keywords
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Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q86TU7 (SETD3_HUMAN) |
| Scope | Eukaryota |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [14]
- Retrieve set of proteins with 3D structure for this domain