ProRule PRU00898

General rule information [?]

Accession PRU00898
Dates 25-NOV-2011 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain;
Predictors PROSITE; PS51565; SAM_MT85_SETD3
Name SETD3 actin-histidine N-methyltransferase (EC
Function SETD3 Actin-histidine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-histidine-[actin] to form N(tele)-methyl-L-histidine-[actin] and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Example(s) Q86TU7 (SETD3_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19369, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:11600, ChEBI:CHEBI:15378, ChEBI:CHEBI:16367, ChEBI:CHEBI:29979, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19370;
SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0018021; Biological process:peptidyl-histidine methylation
GO:0030047; Biological process:actin modification

Features [?]

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]