General rule information
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Accession |
PRU00898 |
Dates |
25-NOV-2011 (Created) 21-NOV-2019 (Last updated, Version 14) |
Predictors |
PROSITE; PS51565; SAM_MT85_SETD3
|
Name |
SETD3 actin-histidine N-methyltransferase (EC 2.1.1.85) |
Function |
SETD3 Actin-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-histidine-[actin] to form N(tele)-methyl-L-histidine-[actin] and S-adenosyl-L-homocysteine. |
Propagated annotation
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Catalytic activity |
RHEA:19369: L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine
EC 2.1.1.85
PhysiologicalDirection=left-to-right
(RHEA:19370)
|
Similarity |
Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. |
GO:0018021; Biological process: peptidyl-histidine methylation.
GO:0030047; Biological process: actin modification.
Additional information
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Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q86TU7 (SETD3_HUMAN) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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