ProRule PRU00898
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00898 |
| Accession | PRU00898 |
| Dates | 25-NOV-2011 (Created)
3-SEP-2024 (Last updated, Version 15) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51565; SAM_MT85_SETD3 |
Name | SETD3 actin-histidine N-methyltransferase (EC 2.1.1.85) |
| Function | SETD3 Actin-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-histidine-[actin] to form N(tele)-methyl-L-histidine-[actin] and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q86TU7 (SETD3_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.85; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)- methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:19369, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:11600, ChEBI:CHEBI:15378, ChEBI:CHEBI:16367, ChEBI:CHEBI:29979, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.85; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19370; |
| SIMILARITY | Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. |
Keywords
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Gene Ontology
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| GO:0018021; Biological process:peptidyl-histidine methylation |
| GO:0030047; Biological process:actin modification |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain