PRU00901
General rule information
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| Accession | PRU00901 |
| Dates | 25-NOV-2011 (Created) 30-SEP-2022 (Last updated, Version 11) |
| Data class | Domain |
| Predictors | PROSITE; PS51568; SAM_MT43_SET2_1 |
| Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
| Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.-; |
Comments
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| Catalytic activity | RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
| Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. |
Gene Ontology
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GO:0046975; Molecular function: histone H3K36 methyltransferase activity.
Keywords
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Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q757Y8 (SET2_ASHGO) |
| Scope | Eukaryota |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [18]
- Retrieve set of proteins with 3D structure for this domain