ProRule PRU00901
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00901 |
| Accession | PRU00901 |
| Dates | 25-NOV-2011 (Created)
3-SEP-2024 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51568; SAM_MT43_SET2_1 |
Name | Histone-lysine N-methyltransferase (EC 2.1.1.43) |
| Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q757Y8 (SET2_EREGS); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L- lysyl-[histone] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; |
| SIMILARITY | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. |
Keywords
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Gene Ontology
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| GO:0046975; Molecular function:histone H3K36 methyltransferase activity |
Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [18] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain