PRU00902
General rule information
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Accession | PRU00902 |
Dates | 28-FEB-2012 (Created) 27-MAR-2023 (Last updated, Version 22) |
Data class | Domain |
Predictors | PROSITE; PS51569; DOT1 |
Name | Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) |
Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
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Description
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case <FTGroup:1>
+ RecName: EC 2.1.1.-; |
Comments
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Catalytic activity | RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. |
end case
Gene Ontology
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case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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end case
Features
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From: PS51569 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | DOT1 # |
case <FTGroup:1>
end case
Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q04089 (DOT1_YEAST) |
Scope | Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Eukaryota [21]
- Retrieve set of proteins with 3D structure for this domain