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annotation rule: PRU00902

General rule information [?]

Accession PRU00902
Dates 28-FEB-2012 (Created)
21-NOV-2019 (Last updated, Version 16)
Data class Domain
Predictors PROSITE; PS51569; DOT1
Name Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43)
Function Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0018024; Molecular function: histone-lysine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

end case


Features [?]

From: PS51569
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DOT1 #        
case <FTGroup:1>
REGION     120     123       S-adenosyl-L-methionine binding     Y-G-E-x  
REGION     143     152       S-adenosyl-L-methionine binding     [FLV]-x-D-x-G-[ACS]-G-x-G-x  
REGION     206     207       S-adenosyl-L-methionine binding     x-F  
end case

BINDING     170     170       S-adenosyl-L-methionine     [DE]   1

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined