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General rule information [?]

Accession PRU00902
Dates 28-FEB-2012 (Created)
27-MAR-2023 (Last updated, Version 22)
Data class Domain
Predictors PROSITE; PS51569; DOT1
Name Histone-lysine N-methyltransferase DOT1 (EC
Function Histone-lysine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ RecName: EC 2.1.1.-;

Comments [?]

Catalytic activity RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0042054; Molecular function: histone methyltransferase activity.
GO:0034968; Biological process: histone lysine methylation.
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

end case

Features [?]

From: PS51569
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DOT1 #        
case <FTGroup:1>
BINDING     120     123       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     Y-G-E-x  
BINDING     143     152       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [FLV]-x-D-x-G-[ACS]-G-x-G-x  
BINDING     206     207       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     x-F  
end case

BINDING     170     170       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [DE]   1

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q04089 (DOT1_YEAST)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]