ProRule PRU00902
General rule information
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| Accession | PRU00902 |
| Dates | 28-FEB-2012 (Created)
3-SEP-2024 (Last updated, Version 24) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51569; DOT1 |
Name | Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) |
| Function | Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q04089 (DOT1_YEAST); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L- lysyl-[histone] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. |
| end case | |
Keywords
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Gene Ontology
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| case <FTGroup:1> | |
| GO:0032259; Biological process:methylation | |
| GO:0042054; Molecular function:histone methyltransferase activity | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0008168; Molecular function:methyltransferase activity | |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process | |
Features
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| From: PS51569 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DOT1 #" | |||||||||
| case <FTGroup:1> | ||||||||||||
| BINDING | 120 | 123 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y-G-E-x | ||||||||
| BINDING | 143 | 152 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[FLV]-x-D-x-G-[ACS]-G-x-G-x | ||||||||
| BINDING | 206 | 207 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
x-F | ||||||||
| end case | ||||||||||||
| BINDING | 170 | 170 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE] | 1 | |||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [21] All [ 21 ]
- Retrieve set of proteins with 3D structure for this domain