General rule information
[?]
Accession |
PRU00902 |
Dates |
28-FEB-2012 (Created) 19-NOV-2022 (Last updated, Version 20) |
Name |
Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) |
Function |
Histone-lysine N-methyltransferase (EC 2.1.1.43) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
[?]
case <FTGroup:1>
Catalytic activity |
RHEA:10024: L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine
|
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. |
end case
case <FTGroup:1>
GO:0018024; Molecular function: histone lysine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
end case
From: PS51569 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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DOT1 #
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case <FTGroup:1>
BINDING
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120
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123
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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Y-G-E-x
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BINDING
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143
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152
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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[FLV]-x-D-x-G-[ACS]-G-x-G-x
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BINDING
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206
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207
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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x-F
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end case
BINDING
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170
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170
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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[DE]
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1
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Additional information
[?]
Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q04089 (DOT1_YEAST) |
Scope |
Eukaryota |
Comments |
None |
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UniProtKB rule member sequences
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