ProRule PRU00902

General rule information [?]

Accession PRU00902
Dates 28-FEB-2012 (Created)
1-MAR-2024 (Last updated, Version 23)
Data class Domain;
Predictors PROSITE; PS51569; DOT1
Name Histone-lysine N-methyltransferase DOT1 (EC
Function Histone-lysine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Example(s) Q04089 (DOT1_YEAST);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=2.1.1.-;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
end case

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0032259; Biological process:methylation
GO:0042054; Molecular function:histone methyltransferase activity
GO:0016740; Molecular function:transferase activity
GO:0008168; Molecular function:methyltransferase activity
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51569
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DOT1 #"
case <FTGroup:1>
BINDING 120 123 /ligand="S-adenosyl-L-methionine"
BINDING 143 152 /ligand="S-adenosyl-L-methionine"
BINDING 206 207 /ligand="S-adenosyl-L-methionine"
end case
BINDING 170 170 /ligand="S-adenosyl-L-methionine"
[DE] 1

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]