General rule information
[?]
Accession |
PRU00910 |
Dates |
25-NOV-2011 (Created) 10-JUL-2020 (Last updated, Version 13) |
case <Length>=315> and <Length<=473>
Predictors |
PROSITE; PS51577; SAM_MT43_SET7
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end case
Name |
Histone-lysine N-methyltransferase |
Function |
Histone-lysine N-methyltransferase is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
Propagated annotation
[?]
Catalytic activity |
RHEA:60264: L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
EC 2.1.1.364
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Similarity |
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily. |
GO:0018024; Molecular function: histone-lysine N-methyltransferase activity.
From: PS51577 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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247
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249
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S-adenosyl-L-methionine binding
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Additional information
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Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q8WTS6 (SETD7_HUMAN) |
Scope |
Eukaryota; Chordata |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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