ProRule PRU00910
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00910 |
| Accession | PRU00910 |
| Dates | 25-NOV-2011 (Created)
3-SEP-2024 (Last updated, Version 22) |
| Data class | Domain; |
| Predictors |
case c? <Length>=315> and <Length<=473>
PROSITE; PS51577; SAM_MT43_SET7 end case
|
Name | Histone-lysine N-methyltransferase |
| Function | Histone-lysine N-methyltransferase is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota Chordata |
| Example(s) | Q8WTS6 (SETD7_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.364; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)- methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364; |
| SIMILARITY | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily. |
Keywords
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Gene Ontology
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| GO:0032259; Biological process:methylation |
| GO:0042054; Molecular function:histone methyltransferase activity |
| GO:0016740; Molecular function:transferase activity |
| GO:0008168; Molecular function:methyltransferase activity |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51577 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 247 | 249 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain