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ProRule PRU00910


General rule information [?]

Accession PRU00910
Dates 25-NOV-2011 (Created)
1-MAR-2024 (Last updated, Version 21)
Data class Domain;
Predictors
case c? <Length>=315> and <Length<=473>
PROSITE; PS51577; SAM_MT43_SET7
end case
Name Histone-lysine N-methyltransferase
Function Histone-lysine N-methyltransferase is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to L-lysine- [histone] to form N(6)-methyl-L-lysine-[histone] and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Chordata
Example(s) Q8WTS6 (SETD7_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.364;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0032259; Biological process:methylation
GO:0042054; Molecular function:histone methyltransferase activity
GO:0016740; Molecular function:transferase activity
GO:0008168; Molecular function:methyltransferase activity
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51577
Key From To Description Tag Condition FTGroup
BINDING 247 249 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]