ProRule PRU00924

General rule information [?]

Accession	PRU00924
Dates	25-NOV-2011 (Created) 11-JAN-2024 (Last updated, Version 21)
Data class	Domain;
Predictors	PROSITE; PS51591; RNA_CAP01_NS5_MT
Name	mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57)
Function	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) is an enzyme that transfers a methyl group from SAM to G(5')pppR-RNA to form m(7)G(5')pppR-RNA and SAH. mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) is an enzyme that transfers a methyl group from SAM to m(7)G(5')pppR-RNA to form m(7)G(5')pppRm-RNA and SAH.
Scope(s)	Viruses Flavivirus
Example(s)	P12823 (POLG_DEN2P); P06935 (POLG_WNV); P03314 (POLG_YEFV1);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name

+ RecName: EC=2.1.1.56;
EC=2.1.1.57;

Comments [?]

CATALYTIC ACTIVITY	Reaction=a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S- adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA- COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617; EC=2.1.1.56;
CATALYTIC ACTIVITY	Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- adenosyl-L-homocysteine; Xref=Rhea:RHEA:67020, Rhea:RHEA-COMP:17167, Rhea:RHEA-COMP:17168, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167609; EC=2.1.1.57;
SIMILARITY	In the N-terminal section; belongs to the class I-like SAM- binding methyltransferase superfamily. mRNA cap 0-1 NS5-type methyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding

GO:0004482; Molecular function:mRNA 5'-cap (guanine-N7-)-methyltransferase activity

GO:0004483; Molecular function:mRNA (nucleoside-2'-O-)-methyltransferase activity

GO:0006370; Biological process:7-methylguanosine mRNA capping

GO:0032259; Biological process:methylation

GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51591

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="mRNA cap 0-1 NS5-type MT #"

BINDING