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General rule information [?]

Accession PRU00929
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain
case <Length>=235> and <Length<=353>
Predictors PROSITE; PS51597; SAM_HNMT
end case

Name Histamine N-methyltransferase
Function Histamine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:19301: histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Gene Ontology [?]

GO:0046539; Molecular function: histamine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Features [?]

From: PS51597
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     28     28       /ligand="substrate     E  
BINDING     283     283       /ligand="substrate     N  
BINDING     60     60       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G  
BINDING     89     89       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     E  
BINDING     94     94       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     Q  
BINDING     120     120       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     S  
BINDING     142     142       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     I  
BINDING     283     283       /ligand="substrate     N  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5R7C3 (HNMT_PONAB)
Eukaryota; Euteleostomi
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]