PRU00929
General rule information
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Accession | PRU00929 |
Dates | 14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 9) |
Data class | Domain |
case <Length>=235> and <Length<=353>
Predictors | PROSITE; PS51597; SAM_HNMT |
end case
Name | Histamine N-methyltransferase |
Function | Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.8; |
Comments
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Catalytic activity | RHEA:19301: histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine
EC 2.1.1.8 |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. |
Gene Ontology
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GO:0046539; Molecular function: histamine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Features
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From: PS51597 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 28 | 28 | /ligand="substrate | E | ||||||||
BINDING | 283 | 283 | /ligand="substrate | N | ||||||||
BINDING | 60 | 60 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
BINDING | 89 | 89 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | E | ||||||||
BINDING | 94 | 94 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Q | ||||||||
BINDING | 120 | 120 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | S | ||||||||
BINDING | 142 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | I | ||||||||
BINDING | 283 | 283 | /ligand="substrate | N |
Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q5R7C3 (HNMT_PONAB) |
Scope | Eukaryota; Euteleostomi |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [12]
- Retrieve set of proteins with 3D structure for this domain