PRU00929

General rule information [?]

Accession	PRU00929
Dates	14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 9)

Data class

Domain

case <Length>=235> and <Length<=353>

Predictors

PROSITE; PS51597; SAM_HNMT

end case

Name	Histamine N-methyltransferase

Function

Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC 2.1.1.8;

Comments [?]

Catalytic activity	RHEA:19301: histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine EC 2.1.1.8
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Gene Ontology [?]

GO:0046539; Molecular function: histamine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Features [?]

From: PS51597

Key From To Description Tag Condition FTGroup

BINDING 28 28 /ligand="substrate E

BINDING 283 283 /ligand="substrate N

BINDING 60 60 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G

BINDING 89 89 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 E

BINDING 94 94 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 Q

BINDING 120 120 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 S

BINDING 142 142 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 I

BINDING 283 283 /ligand="substrate N

Additional information [?]

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q5R7C3 (HNMT_PONAB)
Scope	Eukaryota; Euteleostomi
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [12]
Retrieve set of proteins with 3D structure for this domain