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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00929


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PURL: https://purl.expasy.org/prosite/rule/PRU00929
General rule information [?]

Accession PRU00929
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 11)
Data class Domain;
Predictors
case c? <Length>=235> and <Length<=353>
PROSITE; PS51597; SAM_HNMT
end case
Name Histamine N-methyltransferase
Function Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q5R7C3;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.8;

Comments [?]

CATALYTIC ACTIVITY Reaction=histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:19301, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58432, ChEBI:CHEBI:58600, ChEBI:CHEBI:59789; EC=2.1.1.8;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0046539; Molecular function:histamine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51597
Key From To Description Tag Condition FTGroup
BINDING 28 28 /ligand="substrate" E
BINDING 283 283 /ligand="substrate" N
BINDING 60 60 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 89 89 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 E
BINDING 94 94 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Q
BINDING 120 120 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 S
BINDING 142 142 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 I
BINDING 283 283 /ligand="substrate" N

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]