PROSITE logo

ProRule PRU00929


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00929
General rule information [?]

Accession PRU00929
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 11)
Data class Domain;
Predictors
case c? <Length>=235> and <Length<=353>
PROSITE; PS51597; SAM_HNMT
end case
Name Histamine N-methyltransferase
Function Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q5R7C3 (HNMT_PONAB);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.8;

Comments [?]

CATALYTIC ACTIVITY Reaction=histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:19301, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58432, ChEBI:CHEBI:58600, ChEBI:CHEBI:59789; EC=2.1.1.8;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0046539; Molecular function:histamine N-methyltransferase activity
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51597
Key From To Description Tag Condition FTGroup
BINDING 28 28 /ligand="substrate" E
BINDING 283 283 /ligand="substrate" N
BINDING 60 60 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 89 89 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 E
BINDING 94 94 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Q
BINDING 120 120 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 S
BINDING 142 142 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 I
BINDING 283 283 /ligand="substrate" N

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]