ProRule PRU00929
General rule information
[?]
| PURL | https://purl.expasy.org/prosite/rule/PRU00929 |
| Accession | PRU00929 |
| Dates | 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
case c? <Length>=235> and <Length<=353>
PROSITE; PS51597; SAM_HNMT end case
|
Name | Histamine N-methyltransferase |
| Function | Histamine N-methyltransferase (EC 2.1.1.8) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to histamine to form N(tau) methylhistamine and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q5R7C3 (HNMT_PONAB); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + RecName: EC=2.1.1.8; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:19301, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:58432, ChEBI:CHEBI:58600, ChEBI:CHEBI:59789; EC=2.1.1.8; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0046539; Molecular function:histamine N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
[?]
| From: PS51597 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 28 | 28 | /ligand="substrate" | E | ||||||||
| BINDING | 283 | 283 | /ligand="substrate" | N | ||||||||
| BINDING | 60 | 60 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 89 | 89 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
| BINDING | 94 | 94 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Q | ||||||||
| BINDING | 120 | 120 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
S | ||||||||
| BINDING | 142 | 142 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
I | ||||||||
| BINDING | 283 | 283 | /ligand="substrate" | N | ||||||||
Additional information
[?]
| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [12] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain