PRU00931
General rule information
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Accession | PRU00931 |
Dates | 14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 12) |
Data class | Domain |
Predictors | PROSITE; PS51599; SAM_PEMT_PEM2 |
Name | Phospholipid methyltransferases (EC 2.1.1.17 and EC=2.1.1.71) family |
Function | Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. Phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-methylethanolamine to form phosphatidyl-N- dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N- dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L- homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.17; + RecName: EC 2.1.1.71; |
Comments
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Function | Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). |
Catalytic activity | RHEA:32735: 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.71 |
RHEA:32739: 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine | |
RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.17 |
|
Pathway | Phospholipid metabolism; phosphatidylcholine biosynthesis. |
Similarity | Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. |
Gene Ontology
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GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.
Keywords
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Methyltransferase
S-adenosyl-L-methionine
Transferase
Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
S-adenosyl-L-methionine
Transferase
Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
Additional information
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Size range | 174-211 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q08388 (PEMT_RAT) |
Scope | Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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