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annotation rule: PRU00931

General rule information [?]

Accession PRU00931
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS51599; SAM_PEMT_PEM2
Name Phospholipid methyltransferases (EC and EC= family
Function Phosphatidylethanolamine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. Phosphatidyl-N-methylethanolamine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-methylethanolamine to form phosphatidyl-N- dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N- dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L- homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC; + RecName: EC;

Comments [?]

Function Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Catalytic activity RHEA:32735: 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine
RHEA:32739: 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis.
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.

Gene Ontology [?]

GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.

Keywords [?]

Additional information [?]

Size range 174-211 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q08388 (PEMT_RAT)
Comments None


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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Bacteria [1]
Eukaryota [11]
All [ 12 ]