ProRule PRU00931
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PURL: https://purl.expasy.org/prosite/rule/PRU00931
General rule information
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| Accession | PRU00931 |
| Dates | 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 15) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51599; SAM_PEMT_PEM2 |
Name | Phospholipid methyltransferases (EC 2.1.1.17 and EC=2.1.1.71) family |
| Function | Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. Phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-methylethanolamine to form phosphatidyl-N- dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N- dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L- homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q08388 (PEMT_RAT); |
Propagated annotation
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Identifier, protein and gene names
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Comments
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| FUNCTION | Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). |
| CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S- adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N- dimethylethanolamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:32735, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572, ChEBI:CHEBI:64573; EC=2.1.1.71; |
| CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:32739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572; |
| CATALYTIC ACTIVITY | Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17; |
| PATHWAY | Phospholipid metabolism; phosphatidylcholine biosynthesis. |
| SIMILARITY | Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. |
Keywords
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| Methyltransferase |
| S-adenosyl-L-methionine |
| Transferase |
| Lipid biosynthesis |
| Lipid metabolism |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
Gene Ontology
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| GO:0004608; Molecular function:phosphatidylethanolamine N-methyltransferase activity |
| GO:0000773; Molecular function:phosphatidyl-N-methylethanolamine N-methyltransferase activity |
| GO:0006656; Biological process:phosphatidylcholine biosynthetic process |
Features
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Additional information
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| Size range | 174-211 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [1] Eukaryota [11] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain