ProRule PRU00931

General rule information [?]

Accession PRU00931
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51599; SAM_PEMT_PEM2
Name Phospholipid methyltransferases (EC and EC= family
Function Phosphatidylethanolamine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. Phosphatidyl-N-methylethanolamine N-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-methylethanolamine to form phosphatidyl-N- dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N- dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L- homocysteine.
Scope(s) Eukaryota
Example(s) Q08388 (PEMT_RAT);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;
+ RecName: EC=;

Comments [?]

FUNCTIONCatalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
CATALYTIC ACTIVITY Reaction=1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S- adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N- dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32735, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572, ChEBI:CHEBI:64573; EC=;
CATALYTIC ACTIVITY Reaction=1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S- adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64572;
CATALYTIC ACTIVITY Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=;
PATHWAYPhospholipid metabolism; phosphatidylcholine biosynthesis.
SIMILARITYBelongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0004608; Molecular function:phosphatidylethanolamine N-methyltransferase activity
GO:0000773; Molecular function:phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0080101; Molecular function:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
GO:0006656; Biological process:phosphatidylcholine biosynthetic process

Features [?]

Additional information [?]

Size range 174-211 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]