PRU00931

Accession	PRU00931
Dates	14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 12)

Data class

Domain

Predictors

PROSITE; PS51599; SAM_PEMT_PEM2

Name	Phospholipid methyltransferases (EC 2.1.1.17 and EC=2.1.1.71) family

Function

Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidylethanolamine to form phosphatidyl-N-methylethanolamine and S- adenosyl-L-homocysteine. Phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N-methylethanolamine to form phosphatidyl-N- dimethylethanolamine and S-adenosyl-L-homocysteine. It also transfers a methyl group from S-adenosyl-L-methionine (SAM) to phosphatidyl-N- dimethylethanolamine to form phosphatidylcholine and S-adenosyl-L- homocysteine.

+ RecName: EC 2.1.1.17; + RecName: EC 2.1.1.71;

Function	Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Catalytic activity	RHEA:32735: 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.71
	RHEA:32739: 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine
	RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.17
Pathway	Phospholipid metabolism; phosphatidylcholine biosynthesis.
Similarity	Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.

GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
GO:0000773; Molecular function: phosphatidyl-N-methylethanolamine N-methyltransferase activity.
GO:0080101; Molecular function: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity.
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.

Methyltransferase
S-adenosyl-L-methionine
Transferase
Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism

Size range	174-211 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q08388 (PEMT_RAT)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB/Swiss-Prot sets

Bacteria	[1]
Eukaryota	[11]
All	[ 12 ]