ProRule PRU00932

Accession	PRU00932
Dates	6-MAR-2012 (Created) 19-NOV-2022 (Last updated, Version 13)
Data class	Domain;
Predictors	PROSITE; PS51600; SAM_GNMT
Name	Glycine and glycine/sarcosine N-methyltransferase
Function	Glycine N-methyltransferase (EC 2.1.1.20) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to form sarcosine and S-adenosyl-L-homocysteine. Glycine/sarcosine N-methyltransferase (EC 2.1.1.156) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to form sarcosine and S-adenosyl-L-homocysteine AND transfers a methyl group from S-adenosyl-L-methionine (SAM) to sarcosine to form N,N-dimethylglycine and S-adenosyl-L-homocysteine.
Scope(s)	Eukaryota Eutheria Bacteria
Example(s)	P13255 (GNMT_RAT);

From: PS51600
Key	From	To	Description	Tag	Condition	FTGroup
case <FTGroup:1>
BINDING	122	123	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[DN]-W
end case
BINDING	27	27	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		Y	1
case <FTGroup:1>
BINDING	36	36	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[WY]
BINDING	39	39	/ligand="substrate"		Y
BINDING	46	46	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		R
BINDING	70	70	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[AS]
BINDING	91	91	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		D
BINDING	143	143	/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789"		[FMLQ]
BINDING	145	145	/ligand="substrate"		[NS]
end case
BINDING	179	179	/ligand="substrate"		R	1
case <FTGroup:1>
BINDING	223	223	/ligand="substrate"
end case