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annotation rule: PRU00932

General rule information [?]

Accession PRU00932
Dates 6-MAR-2012 (Created)
27-OCT-2018 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51600; SAM_GNMT
Names Glycine and glycine/sarcosine N-methyltransferase; EC 2.1.1.20 and EC 2.1.1.156
Function Glycine N-methyltransferase (EC 2.1.1.20) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to form sarcosine and S-adenosyl-L-homocysteine. Glycine/sarcosine N-methyltransferase (EC 2.1.1.156) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to glycine to form sarcosine and S-adenosyl-L-homocysteine AND transfers a methyl group from S-adenosyl-L-methionine (SAM) to sarcosine to form N,N-dimethylglycine and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
+ RecName: EC=2.1.1.156;
else case <FTGroup:1>
+ RecName: EC=2.1.1.20;
end case


Comments [?]

case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
Catalytic activity Reaction=glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:32463, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57856, ChEBI:CHEBI:58251, ChEBI:CHEBI:59789; EC=2.1.1.156;.
else case <FTGroup:1>
Catalytic activity Reaction=glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine; Xref=Rhea:RHEA:19937, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:57433, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.20;.
end case

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0017174; Molecular function: glycine N-methyltransferase activity.
end case

case <FTGroup:1> and (<OC:Bacteria> or <OC:Archaea>)
GO:0052730; Molecular function: sarcosine N-methyltransferase activity.
end case

case <FTGroup:1>
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
end case


Keywords [?]

case <FTGroup:1>
end case


Features [?]

case <FTGroup:1>
From: PS51600
Key     From     To       Description   Tag   Condition   FTGroup
REGION     122     123       S-adenosyl-L-methionine binding     [DN]-W  
end case

BINDING     27     27       S-adenosyl-L-methionine     Y   1
case <FTGroup:1>
BINDING     36     36       S-adenosyl-L-methionine     [WY]  
BINDING     39     39       Substrate     Y  
BINDING     46     46       S-adenosyl-L-methionine     R  
BINDING     70     70       S-adenosyl-L-methionine; via carbonyl oxygen     [AS]  
BINDING     91     91       S-adenosyl-L-methionine     D  
BINDING     143     143       S-adenosyl-L-methionine; via carbonyl oxygen     [FMLQ]  
BINDING     145     145       Substrate     [NS]  
end case

BINDING     179     179       Substrate     R   1
case <FTGroup:1>
BINDING     223     223       Substrate        
end case


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P13255 (GNMT_RAT)
Scope
Eukaryota; Eutheria
Bacteria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]