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ProRule PRU00940


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00940
Accession PRU00940
Dates 14-DEC-2011 (Created)
26-SEP-2024 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51608; SAM_MT_UBIE
Name UbiE family SAM-binding methyltransferase
Function 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to 2-methoxy-6-all-trans-polyprenyl-1,4 benzoquinol to form 6-methoxy-3-methyl- 2-all-trans polyprenyl-1,4-benzoquinol and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Example(s) Q54VN2 (COQ5_DICDI);

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Eukaryota>
Protein name + RecName: EC=2.1.1.163;
end case
case <OC:Eukaryota> or <OC:Pseudomonadota>
Protein name + RecName: EC=2.1.1.201;
end case

Comments [?]

case not <OC:Eukaryota>
CATALYTIC ACTIVITY Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;
end case
case <OC:Eukaryota> or <OC:Pseudomonadota>
CATALYTIC ACTIVITY Reaction=a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S- adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]

case not <OC:Eukaryota>
Menaquinone biosynthesis
end case
Methyltransferase
S-adenosyl-L-methionine
Transferase
case <OC:Eukaryota> or <OC:Pseudomonadota>
Ubiquinone biosynthesis
end case

Gene Ontology [?]

GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity
case <OCellular component:Eukaryota> or <OC:Pseudomonadota>
GO:0006744; Biological process:ubiquinone biosynthetic process
end case
case not <OCellular component:Eukaryota>
GO:0009234; Biological process:menaquinone biosynthetic process
end case
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Cross-references [?]

PROSITE PS01183; UBIE_1; 1;
PROSITE PS01184; UBIE_2; 1;

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]