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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00940


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00940
General rule information [?]

Accession PRU00940
Dates 14-DEC-2011 (Created)
26-SEP-2024 (Last updated, Version 14)
Data class Domain;
Predictors PROSITE; PS51608; SAM_MT_UBIE
Name UbiE family SAM-binding methyltransferase
Function 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to 2-methoxy-6-all-trans-polyprenyl-1,4 benzoquinol to form 6-methoxy-3-methyl- 2-all-trans polyprenyl-1,4-benzoquinol and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Example(s) Q54VN2;

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Eukaryota>
Protein name + RecName: EC=2.1.1.163;
end case
case <OC:Eukaryota> or <OC:Pseudomonadota>
Protein name + RecName: EC=2.1.1.201;
end case

Comments [?]

case not <OC:Eukaryota>
CATALYTIC ACTIVITY Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;
end case
case <OC:Eukaryota> or <OC:Pseudomonadota>
CATALYTIC ACTIVITY Reaction=a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S- adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords [?]

case not <OC:Eukaryota>
Menaquinone biosynthesis
end case
Methyltransferase
S-adenosyl-L-methionine
Transferase
case <OC:Eukaryota> or <OC:Pseudomonadota>
Ubiquinone biosynthesis
end case

Gene Ontology [?]

GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity
case <OCellular component:Eukaryota> or <OC:Pseudomonadota>
GO:0006744; Biological process:ubiquinone biosynthetic process
end case
case not <OCellular component:Eukaryota>
GO:0009234; Biological process:menaquinone biosynthetic process
end case
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Cross-references [?]

PROSITE PS01183; UBIE_1; 1;
PROSITE PS01184; UBIE_2; 1;

Features [?]


Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]