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annotation rule: PRU00940

General rule information [?]

Accession PRU00940
Dates 14-DEC-2011 (Created)
27-OCT-2018 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51608; SAM_MT_UBIE
Name UbiE family SAM-binding methyltransferase
Function 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to 2-methoxy-6-all-trans-polyprenyl-1,4 benzoquinol to form 6-methoxy-3-methyl- 2-all-trans polyprenyl-1,4-benzoquinol and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

case not <OC:Eukaryota>
+ RecName: EC=2.1.1.163;
end case

case <OC:Eukaryota> or <OC:Proteobacteria>
+ RecName: EC=2.1.1.201;
end case


Comments [?]

case not <OC:Eukaryota>
Catalytic activity Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163;.
end case

case <OC:Eukaryota> or <OC:Proteobacteria>
Catalytic activity Reaction=a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201;.
end case

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Cross-references [?]

PROSITE PS01183; UBIE_1; 1;
PS01184; UBIE_2; 1;

Gene Ontology [?]

GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.
case <OC:Eukaryota> or <OC:Proteobacteria>
GO:0006744; Biological process: ubiquinone biosynthetic process.
end case

case not <OC:Eukaryota>
GO:0009234; Biological process: menaquinone biosynthetic process.
end case

GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

case not <OC:Eukaryota>
end case

case <OC:Eukaryota> or <OC:Proteobacteria>
end case


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q54VN2 (COQ5_DICDI)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]