ProRule PRU00940
General rule information
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| Accession | PRU00940 |
| Dates | 14-DEC-2011 (Created)
26-SEP-2024 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51608; SAM_MT_UBIE |
Name | UbiE family SAM-binding methyltransferase |
| Function | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (EC 2.1.1.201) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to 2-methoxy-6-all-trans-polyprenyl-1,4 benzoquinol to form 6-methoxy-3-methyl- 2-all-trans polyprenyl-1,4-benzoquinol and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota |
| Example(s) | Q54VN2 (COQ5_DICDI); |
Propagated annotation
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Identifier, protein and gene names
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| case not <OC:Eukaryota> | |
| Protein name | + RecName: EC=2.1.1.163; |
| end case | |
| case <OC:Eukaryota> or <OC:Pseudomonadota> | |
| Protein name | + RecName: EC=2.1.1.201; |
| end case | |
Comments
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| case not <OC:Eukaryota> | |
| CATALYTIC ACTIVITY | Reaction=a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:42640, Rhea:RHEA-COMP:9539, Rhea:RHEA-COMP:9563, ChEBI:CHEBI:15378, ChEBI:CHEBI:18151, ChEBI:CHEBI:55437, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.163; |
| end case | |
| case <OC:Eukaryota> or <OC:Pseudomonadota> | |
| CATALYTIC ACTIVITY | Reaction=a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S- adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:28286, Rhea:RHEA-COMP:10858, Rhea:RHEA-COMP:10859, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:84166, ChEBI:CHEBI:84167; EC=2.1.1.201; |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. |
Keywords
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| case not <OC:Eukaryota> | |
| Menaquinone biosynthesis | |
| end case | |
| Methyltransferase | |
| S-adenosyl-L-methionine | |
| Transferase | |
| case <OC:Eukaryota> or <OC:Pseudomonadota> | |
| Ubiquinone biosynthesis | |
| end case | |
Gene Ontology
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| GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity | |
| case <OCellular component:Eukaryota> or <OC:Pseudomonadota> | |
| GO:0006744; Biological process:ubiquinone biosynthetic process | |
| end case | |
| case not <OCellular component:Eukaryota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| end case | |
| GO:0032259; Biological process:methylation | |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process | |
Cross-references
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Features
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [394] Eukaryota [17] All [ 411 ]
- Retrieve set of proteins with 3D structure for this domain