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| annotation rule: PRU00944 |
General rule information
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| Accession | PRU00944 |
| Dates | 14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 8) |
| Data class | Domain |
| Predictors | PROSITE; PS51612; SAM_MT_2O_PK |
| Name | Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family |
| Function | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.-; |
Comments
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| Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family. |
Keywords
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Features
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| From: PS51612 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 167 | 246 | Binding to NPH-I | P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV] | ||||||||
| REGION | 175 | 178 | mRNA cap binding | R-C-P-F | ||||||||
| REGION | 203 | 205 | mRNA cap binding | S-A-E | ||||||||
| ACT_SITE | 173 | 173 | For methyltransferase activity | K | ||||||||
| BINDING | 19 | 19 | mRNA cap | Y | ||||||||
| BINDING | 38 | 38 | S-adenosyl-L-methionine | Q | ||||||||
| BINDING | 65 | 65 | S-adenosyl-L-methionine | Y | ||||||||
| BINDING | 67 | 67 | S-adenosyl-L-methionine; via carbonyl oxygen | G | ||||||||
| BINDING | 71 | 71 | S-adenosyl-L-methionine; via amide nitrogen | G | ||||||||
| BINDING | 90 | 90 | S-adenosyl-L-methionine | D | ||||||||
| BINDING | 93 | 93 | S-adenosyl-L-methionine | R | ||||||||
| BINDING | 112 | 112 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen | V | ||||||||
| BINDING | 134 | 134 | S-adenosyl-L-methionine | D | ||||||||
| BINDING | 180 | 180 | mRNA cap | D | ||||||||
| BINDING | 230 | 230 | mRNA cap | E | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P07617 (MCE_VACCW) |
| Scope | Viruses; Chordopoxvirinae |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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