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annotation rule: PRU00944

General rule information [?]

Accession PRU00944
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51612; SAM_MT_2O_PK
Name Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family
Function Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.-;

Comments [?]

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase
mRNA capping
mRNA processing

Features [?]

From: PS51612
Key     From     To       Description   Tag   Condition   FTGroup
REGION     167     246       Binding to NPH-I     P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV]  
REGION     175     178       mRNA cap binding     R-C-P-F  
REGION     203     205       mRNA cap binding     S-A-E  
ACT_SITE     173     173       For methyltransferase activity     K  
BINDING     19     19       mRNA cap     Y  
BINDING     38     38       S-adenosyl-L-methionine     Q  
BINDING     65     65       S-adenosyl-L-methionine     Y  
BINDING     67     67       S-adenosyl-L-methionine; via carbonyl oxygen     G  
BINDING     71     71       S-adenosyl-L-methionine; via amide nitrogen     G  
BINDING     90     90       S-adenosyl-L-methionine     D  
BINDING     93     93       S-adenosyl-L-methionine     R  
BINDING     112     112       S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen     V  
BINDING     134     134       S-adenosyl-L-methionine     D  
BINDING     180     180       mRNA cap     D  
BINDING     230     230       mRNA cap     E  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P07617 (MCE_VACCW)
Scope
Viruses; Chordopoxvirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]