We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU00944

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00944

General rule information [?]

Accession	PRU00944
Dates	14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 12)
Data class	Domain;
Predictors	PROSITE; PS51612; SAM_MT_2O_PK
Name	Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family
Function	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Scope(s)	Viruses Chordopoxvirinae
Example(s)	P07617;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name

+ RecName: EC=2.1.1.-;

Comments [?]

SIMILARITY

Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.

Keywords [?]

Methyltransferase

S-adenosyl-L-methionine

Transferase

mRNA capping

mRNA processing

Features [?]

From: PS51612

Key

From

Description

Tag

Condition

FTGroup

REGION

167

246

/note="Binding to NPH-I"

P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV]

BINDING

175

178

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

R-C-P-F

BINDING

203

205

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

S-A-E

ACT_SITE

173

/note="For methyltransferase activity"

BINDING

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

BINDING