ProRule PRU00944

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PURL: https://purl.expasy.org/prosite/rule/PRU00944

General rule information [?]

Accession	PRU00944
Dates	14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 11)
Data class	Domain;
Predictors	PROSITE; PS51612; SAM_MT_2O_PK
Name	Poxvirus/kinetoplastid ribose 2'-O-methyltransferase (EC 2.1.1.57) family
Function	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Scope(s)	Viruses Chordopoxvirinae
Example(s)	P07617 (MCE_VACCW);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name

+ RecName: EC=2.1.1.-;

Comments [?]

SIMILARITY

Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.

Keywords [?]

Methyltransferase

S-adenosyl-L-methionine

Transferase

mRNA capping

mRNA processing

Features [?]

From: PS51612

Key

From

Description

Tag

Condition

FTGroup

REGION

167

246

/note="Binding to NPH-I"

P-[AIV]-A-S-S-L-K-W-R-C-P-F-P-D-Q-W-I-[KR]-D-F-Y-[IV]-P-[CH]-G-[DN]-[EK]-[FM]-[LS]-Q-P-F-A-P-[PS]-[FY]-S-A-E-M-R-L-L-S-[CI]-Y-[ST]-[GR]-[AET]-[NP]-[IM]-R-L-[IKT]-[CR]-[IV]-[DT]-[KQ]-[NQS]-[AD]-[ASV]-[ISV]-[EKN]-Y-E-K-K-M-[FY]-Y-L-N-[KT]-[IK]-[IV]-R-[NP]-[KR]-[IV]-[IV]-[ILV]

BINDING

175

178

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

R-C-P-F

BINDING

203

205

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

S-A-E

ACT_SITE

173

/note="For methyltransferase activity"

BINDING

/ligand="mRNA"
/ligand_id="ChEBI:CHEBI:33699"
/ligand_part="mRNA cap"

BINDING