General rule information
[?]
Accession |
PRU00948 |
Dates |
14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 7) |
case <Length>=211> and <Length<=317>
Predictors |
PROSITE; PS51616; SAM_NNMT_PNMT_TEMT_2
|
end case
Name |
Amine N-methyltransferase |
Function |
Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. |
Propagated annotation
[?]
Catalytic activity |
RHEA:53928: a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
|
|
RHEA:53924: a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
|
|
RHEA:23136: a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
|
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
GO:0030748; Molecular function: amine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
From: PS51616 |
Key
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From
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To
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Description
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|
Tag
|
|
Condition
|
|
FTGroup
|
REGION
|
|
64
|
|
65
|
|
S-adenosyl-L-methionine binding
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|
|
|
|
|
|
REGION
|
|
143
|
|
144
|
|
S-adenosyl-L-methionine binding
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|
|
|
|
|
|
BINDING
|
|
21
|
|
21
|
|
S-adenosyl-L-methionine
|
|
|
|
Y
|
|
|
BINDING
|
|
26
|
|
26
|
|
S-adenosyl-L-methionine
|
|
|
|
Y
|
|
|
BINDING
|
|
70
|
|
70
|
|
S-adenosyl-L-methionine
|
|
|
|
Y
|
|
|
BINDING
|
|
86
|
|
86
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
BINDING
|
|
91
|
|
91
|
|
S-adenosyl-L-methionine
|
|
|
|
N
|
|
|
BINDING
|
|
164
|
|
164
|
|
S-adenosyl-L-methionine; via carbonyl oxygen
|
|
|
|
[FLT]
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Additional information
[?]
Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
O97972 (INMT_RABIT) |
Scope |
Eukaryota; Euarchontoglires |
Comments |
None |
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(CC BY-NC-ND 4.0) License, see
prosite_license.html.