We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00948
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00948
General rule information
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| Accession | PRU00948 |
| Dates | 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
case c? <Length>=211> and <Length<=317>
PROSITE; PS51616; SAM_NNMT_PNMT_TEMT_2 end case
|
Name | Amine N-methyltransferase |
| Function | Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Euarchontoglires |
| Example(s) | O97972; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.49; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:53928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:137982, ChEBI:CHEBI:137983; EC=2.1.1.49; |
| CATALYTIC ACTIVITY | Reaction=a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:53924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:137419, ChEBI:CHEBI:137984; EC=2.1.1.49; |
| CATALYTIC ACTIVITY | Reaction=a primary amine + S-adenosyl-L-methionine = a methylated primary amine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:23136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65296, ChEBI:CHEBI:131823; EC=2.1.1.49; |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Keywords
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Gene Ontology
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| GO:0030748; Molecular function:amine N-methyltransferase activity |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51616 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 64 | 65 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| BINDING | 143 | 144 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
|||||||||
| BINDING | 21 | 21 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 26 | 26 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 70 | 70 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 86 | 86 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 91 | 91 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
| BINDING | 164 | 164 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[FLT] | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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