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annotation rule: PRU00948

General rule information [?]

Accession PRU00948
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
case <Length>=211> and <Length<=317>
Predictors PROSITE; PS51616; SAM_NNMT_PNMT_TEMT_2
end case

Name Amine N-methyltransferase
Function Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.49;

Comments [?]

Catalytic activity RHEA:53928: a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
RHEA:53924: a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
RHEA:23136: a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

Gene Ontology [?]

GO:0030748; Molecular function: amine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51616
Key     From     To       Description   Tag   Condition   FTGroup
REGION     64     65       S-adenosyl-L-methionine binding        
REGION     143     144       S-adenosyl-L-methionine binding        
BINDING     21     21       S-adenosyl-L-methionine     Y  
BINDING     26     26       S-adenosyl-L-methionine     Y  
BINDING     70     70       S-adenosyl-L-methionine     Y  
BINDING     86     86       S-adenosyl-L-methionine     D  
BINDING     91     91       S-adenosyl-L-methionine     N  
BINDING     164     164       S-adenosyl-L-methionine; via carbonyl oxygen     [FLT]  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example O97972 (INMT_RABIT)
Scope
Eukaryota; Euarchontoglires
Comments None

Copyright

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