 |
|
| annotation rule: PRU00948 |
General rule information
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| Accession | PRU00948 |
| Dates | 14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 7) |
| Data class | Domain |
case <Length>=211> and <Length<=317>
| Predictors | PROSITE; PS51616; SAM_NNMT_PNMT_TEMT_2 |
end case
| Name | Amine N-methyltransferase |
| Function | Amine N-methyltransferase (EC 2.1.1.49) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to an amine to form a methylated amine and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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| + RecName: EC 2.1.1.49; |
Comments
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| Catalytic activity | RHEA:53928: a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49 |
| RHEA:53924: a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49 |
|
| RHEA:23136: a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.49 |
|
| Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. |
Gene Ontology
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GO:0030748; Molecular function: amine N-methyltransferase activity.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Features
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| From: PS51616 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 64 | 65 | S-adenosyl-L-methionine binding | |||||||||
| REGION | 143 | 144 | S-adenosyl-L-methionine binding | |||||||||
| BINDING | 21 | 21 | S-adenosyl-L-methionine | Y | ||||||||
| BINDING | 26 | 26 | S-adenosyl-L-methionine | Y | ||||||||
| BINDING | 70 | 70 | S-adenosyl-L-methionine | Y | ||||||||
| BINDING | 86 | 86 | S-adenosyl-L-methionine | D | ||||||||
| BINDING | 91 | 91 | S-adenosyl-L-methionine | N | ||||||||
| BINDING | 164 | 164 | S-adenosyl-L-methionine; via carbonyl oxygen | [FLT] | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | O97972 (INMT_RABIT) |
| Scope | Eukaryota; Euarchontoglires |
| Comments | None |
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