General rule information
[?]
Accession |
PRU00952 |
Dates |
14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 10) |
Predictors |
PROSITE; PS51620; SAM_TRM61
|
Names |
tRNA (adenine(57)-N(1)/adenine(58)-N(1) or adenine(58)-N(1))-; methyltransferase |
Function |
tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to adenine(58) in tRNA to form N(1)-methyladenine(58) in tRNA and S-adenosyl-L- homocysteine. tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase (EC=2.1.1.219) is an enzyme that transfers a methyl group from the S-adenosyl-L-methionine (SAM) to adenine(57)/adenine(58) in tRNA to form N(1)-methyladenine57/N(1)- methyladenine58 in tRNA and S-adenosyl-L- homocysteine. |
Propagated annotation
[?]
case <OC:Archaea>
else
end case
case <OC:Archaea>
Catalytic activity |
RHEA:41740: adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine
EC 2.1.1.219
|
else
Catalytic activity |
RHEA:43152: adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.220
|
end case
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. |
GO:0016429; Molecular function: tRNA (adenine-N1-)-methyltransferase activity.
GO:0032259; Biological process: methylation.
From: PS51620 |
Key
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From
|
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To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
BINDING
|
|
102
|
|
102
|
|
S-adenosyl-L-methionine
|
|
|
|
S
|
|
|
BINDING
|
|
123
|
|
123
|
|
S-adenosyl-L-methionine
|
|
|
|
E
|
|
|
BINDING
|
|
151
|
|
151
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
BINDING
|
|
170
|
|
170
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
Additional information
[?]
Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q755M8 (TRM61_ASHGO) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]