ProRule PRU00952

General rule information [?]

Accession	PRU00952
Dates	14-DEC-2011 (Created) 3-SEP-2024 (Last updated, Version 15)
Data class	Domain;
Predictors	PROSITE; PS51620; SAM_TRM61
Name	tRNA (adenine(57)-N(1)/adenine(58)-N(1) or adenine(58)-N(1))-
Function	tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to adenine(58) in tRNA to form N(1)-methyladenine(58) in tRNA and S-adenosyl-L- homocysteine. tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase (EC=2.1.1.219) is an enzyme that transfers a methyl group from the S-adenosyl-L-methionine (SAM) to adenine(57)/adenine(58) in tRNA to form N(1)-methyladenine57/N(1)- methyladenine58 in tRNA and S-adenosyl-L- homocysteine.
Scope(s)	Eukaryota
Example(s)	Q755M8 (TRM61_EREGS);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Archaea>
Protein name	+ RecName: EC=2.1.1.219;
else
Protein name	+ RecName: EC=2.1.1.220;
end case

Comments [?]

case <OC:Archaea>
CATALYTIC ACTIVITY	Reaction=adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L- methionine = N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+); Xref=Rhea:RHEA:41740, Rhea:RHEA-COMP:9580, Rhea:RHEA-COMP:9582, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.219;
else
CATALYTIC ACTIVITY	Reaction=adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)- methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:43152, Rhea:RHEA-COMP:10365, Rhea:RHEA-COMP:10366, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; EC=2.1.1.220;
end case
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

Keywords [?]

Methyltransferase

S-adenosyl-L-methionine

Transferase

tRNA processing

Gene Ontology [?]

case <OCellular component:Archaea>
GO:0043827; Molecular function:tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0160107; Molecular function:tRNA (adenine(58)-N1)-methyltransferase activity
end case
GO:0032259; Biological process:methylation

Features [?]

From: PS51620

Key

From

Description

Tag

Condition

FTGroup

BINDING

102

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

123

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

151

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

BINDING

170

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

Additional information [?]

Size range	unlimited amino acids
Related rules	None
Fusion	None
Repeats	1
Topology	Undefined

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View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Archaea	[2]
Bacteria	[4]
Eukaryota	[18]
All	[ 24 ]

Retrieve set of proteins with 3D structure for this domain