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annotation rule: PRU00952

General rule information [?]

Accession PRU00952
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51620; SAM_TRM61
Names tRNA (adenine(57)-N(1)/adenine(58)-N(1) or adenine(58)-N(1))-; methyltransferase
Function tRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to adenine(58) in tRNA to form N(1)-methyladenine(58) in tRNA and S-adenosyl-L- homocysteine. tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase (EC=2.1.1.219) is an enzyme that transfers a methyl group from the S-adenosyl-L-methionine (SAM) to adenine(57)/adenine(58) in tRNA to form N(1)-methyladenine57/N(1)- methyladenine58 in tRNA and S-adenosyl-L- homocysteine.

Propagated annotation [?]


Description [?]

case <OC:Archaea>
+ RecName: EC 2.1.1.219;
else
+ RecName: EC 2.1.1.220;
end case


Comments [?]

case <OC:Archaea>
Catalytic activity RHEA:41740: adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine
EC 2.1.1.219
else
Catalytic activity RHEA:43152: adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.220
end case

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

Gene Ontology [?]

GO:0016429; Molecular function: tRNA (adenine-N1-)-methyltransferase activity.
GO:0032259; Biological process: methylation.

Keywords [?]

Methyltransferase
S-adenosyl-L-methionine
Transferase
tRNA processing

Features [?]

From: PS51620
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     102     102       S-adenosyl-L-methionine     S  
BINDING     123     123       S-adenosyl-L-methionine     E  
BINDING     151     151       S-adenosyl-L-methionine     D  
BINDING     170     170       S-adenosyl-L-methionine     D  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q755M8 (TRM61_ASHGO)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]