PRU00955
General rule information
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Accession | PRU00955 |
Dates | 14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 9) |
Data class | Domain |
case <OC:Fungi> and <Length>=1149> and <Length<=1723>
Predictors | PROSITE; PS51623; SAM_MT_TRMH_1 |
end case
Name | tRNA guanosine-2'-O-methyltransferase |
Function | tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.34; |
Comments
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Catalytic activity | RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.34 |
Similarity | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. |
Gene Ontology
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GO:0003723; Molecular function: RNA binding.
GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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Features
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From: PS51623 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 1389 | 1389 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
BINDING | 1409 | 1409 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | I |
Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q07527 (TRM3_YEAST) |
Scope | Eukaryota; Saccharomyces |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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