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General rule information [?]

Accession PRU00955
Dates 14-DEC-2011 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain
case <OC:Fungi> and <Length>=1149> and <Length<=1723>
Predictors PROSITE; PS51623; SAM_MT_TRMH_1
end case

Name tRNA guanosine-2'-O-methyltransferase
Function tRNA guanosine-2'-O-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
Similarity Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

Features [?]

From: PS51623
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     1389     1389       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G  
BINDING     1409     1409       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     I  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q07527 (TRM3_YEAST)
Eukaryota; Saccharomyces
Comments None


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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [1]