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annotation rule: PRU00955

General rule information [?]

Accession PRU00955
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
case <OC:Fungi> and <Length>=1149> and <Length<=1723>
Predictors PROSITE; PS51623; SAM_MT_TRMH_1
end case

Name tRNA guanosine-2'-O-methyltransferase
Function tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.34;

Comments [?]

Catalytic activity RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.34
Similarity Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]


Features [?]

From: PS51623
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     1389     1389       S-adenosyl-L-methionine; via carbonyl oxygen     G  
BINDING     1409     1409       S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen     I  

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q07527 (TRM3_YEAST)
Scope
Eukaryota; Saccharomyces
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [1]