PRU00955

Accession	PRU00955
Dates	14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 9)

Data class

Domain

Predictors

PROSITE; PS51623; SAM_MT_TRMH_1

Name	tRNA guanosine-2'-O-methyltransferase

Function

tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine.

+ RecName: EC 2.1.1.34;

Catalytic activity	RHEA:20077: guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.34
Similarity	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

GO:0003723; Molecular function: RNA binding.
GO:0009020; Molecular function: tRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

From: PS51623

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

1389

1389

/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789

G

BINDING

1409

1409

/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789

I

Size range	unlimited amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q07527 (TRM3_YEAST)
Scope	Eukaryota; Saccharomyces
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB/Swiss-Prot sets

Eukaryota

[1]