ProRule PRU00955
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00955 |
| Accession | PRU00955 |
| Dates | 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
case c? <OC:Fungi> and <Length>=1149> and <Length<=1723>
PROSITE; PS51623; SAM_MT_TRMH_1 end case
|
Name | tRNA guanosine-2'-O-methyltransferase |
| Function | tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine. |
| Scope(s) |
Eukaryota Saccharomyces |
| Example(s) | Q07527 (TRM3_YEAST); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.34; |
Comments
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| CATALYTIC ACTIVITY | Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34; |
| SIMILARITY | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. |
Keywords
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Gene Ontology
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| GO:0003723; Molecular function:RNA binding |
| GO:0141100; Molecular function:tRNA (guanine(18)-2'-O)-methyltransferase activity |
| GO:0008033; Biological process:tRNA processing |
| GO:0032259; Biological process:methylation |
| GO:0046500; Biological process:S-adenosylmethionine metabolic process |
Features
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| From: PS51623 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 1389 | 1389 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 1409 | 1409 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
I | ||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [1] All [ 1 ]
- Retrieve set of proteins with 3D structure for this domain