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ProRule PRU00955


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PURL: https://purl.expasy.org/prosite/rule/PRU00955
General rule information [?]

Accession PRU00955
Dates 14-DEC-2011 (Created)
03-SEP-2024 (Last updated, Version 12)
Data class Domain;
Predictors
case c? <OC:Fungi> and <Length>=1149> and <Length<=1723>
PROSITE; PS51623; SAM_MT_TRMH_1
end case
Name tRNA guanosine-2'-O-methyltransferase
Function tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing 2'-O-methylguanosine and S-adenosyl-L-homocysteine.
Scope(s) Eukaryota
Saccharomyces
Example(s) Q07527;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.34;

Comments [?]

CATALYTIC ACTIVITY Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34;
SIMILARITYBelongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
GO:0141100; Molecular function:tRNA (guanine(18)-2'-O)-methyltransferase activity
GO:0008033; Biological process:tRNA processing
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51623
Key From To Description Tag Condition FTGroup
BINDING 1389 1389 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 1409 1409 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 I

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]