ProRule PRU00957

General rule information [?]

Accession PRU00957
Dates 14-DEC-2011 (Created)
13-OCT-2023 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51625; SAM_MT_TRMB
Name tRNA (guanine-N(7)-)-methyltransferase
Function tRNA (guanine-N(7)-)-methyltransferase (EC is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing N(7)-methylguanine and S-adenosyl-L-homocysteine.
Scope(s) Bacteria
Example(s) Q6NU94 (TRMB_XENLA);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)- methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42708, Rhea:RHEA-COMP:10188, Rhea:RHEA-COMP:10189, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74480; EC=;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Keywords [?]

Gene Ontology [?]

GO:0000049; Molecular function:tRNA binding
GO:0008176; Molecular function:tRNA (guanine(46)-N7)-methyltransferase activity
GO:0008033; Biological process:tRNA processing
GO:0032259; Biological process:methylation
GO:0046500; Biological process:S-adenosylmethionine metabolic process

Features [?]

From: PS51625
Key From To Description Tag Condition FTGroup
case <OC:Eukaryota> and <Feature:PS51625:74-75=E-[IL]>
BINDING 74 75 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Eukaryota> and <Feature:PS51625:101-102=N-[AST]>
BINDING 101 102 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Eukaryota> and <Feature:PS51625:197=T>
BINDING 197 199 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Bacteria> and <Feature:PS51625:197-200=T-[AEKNRSY]-[FY]-E>
BINDING 197 200 /ligand="substrate"
end case
ACT_SITE 124 124 D
case <OC:Bacteria>
BINDING 49 49 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Eukaryota>
BINDING 51 51 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Bacteria>
BINDING 74 74 /ligand="S-adenosyl-L-methionine"
BINDING 101 101 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Eukaryota>
BINDING 121 121 /ligand="S-adenosyl-L-methionine"
end case
case <OC:Bacteria>
BINDING 124 124 /ligand="S-adenosyl-L-methionine"
BINDING 128 128 /ligand="substrate" K
BINDING 160 160 /ligand="substrate" D
end case

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]