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annotation rule: PRU00957

General rule information [?]

Accession PRU00957
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51625; SAM_MT_TRMB
Name tRNA (guanine-N(7)-)-methyltransferase
Function tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing N(7)-methylguanine and S-adenosyl-L-homocysteine.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.1.1.33;

Comments [?]

Catalytic activity RHEA:42708: guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.33
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Gene Ontology [?]

GO:0000049; Molecular function: tRNA binding.
GO:0008176; Molecular function: tRNA (guanine-N7-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.

Keywords [?]

case <OC:Eukaryota>
end case


Features [?]

case <OC:Eukaryota> and <Feature:PS51625:74-75=E-[IL]>
From: PS51625
Key     From     To       Description   Tag   Condition   FTGroup
REGION     74     75       S-adenosyl-L-methionine binding        
end case

case <OC:Eukaryota> and <Feature:PS51625:101-102=N-[AST]>
REGION     101     102       S-adenosyl-L-methionine binding        
end case

case <OC:Eukaryota> and <Feature:PS51625:197=T>
REGION     197     199       S-adenosyl-L-methionine binding        
end case

case <OC:Bacteria> and <Feature:PS51625:197-200=T-[AEKNRSY]-[FY]-E>
REGION     197     200       Substrate binding        
end case

ACT_SITE     124     124             D  
case <OC:Bacteria>
BINDING     49     49       S-adenosyl-L-methionine     [DE]  
end case

case <OC:Eukaryota>
BINDING     51     51       S-adenosyl-L-methionine; via carbonyl oxygen     G  
end case

case <OC:Bacteria>
BINDING     74     74       S-adenosyl-L-methionine     [DE]  
BINDING     101     101       S-adenosyl-L-methionine     [DEN]  
end case

case <OC:Eukaryota>
BINDING     121     121       S-adenosyl-L-methionine; via carbonyl oxygen     [CL]  
end case

case <OC:Bacteria>
BINDING     124     124       S-adenosyl-L-methionine     D  
BINDING     128     128       Substrate     K  
BINDING     160     160       Substrate     D  
end case


Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6NU94 (TRMB_XENLA)
Scope
Bacteria
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]