General rule information
[?]
Accession |
PRU00957 |
Dates |
14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 8) |
Predictors |
PROSITE; PS51625; SAM_MT_TRMB
|
Name |
tRNA (guanine-N(7)-)-methyltransferase |
Function |
tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing N(7)-methylguanine and S-adenosyl-L-homocysteine. |
Propagated annotation
[?]
Catalytic activity |
RHEA:42708: guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.33
|
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. |
GO:0000049; Molecular function: tRNA binding.
GO:0008176; Molecular function: tRNA (guanine-N7-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
case <OC:Eukaryota>
end case
case <OC:Eukaryota> and <Feature:PS51625:74-75=E-[IL]>
From: PS51625 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
REGION
|
|
74
|
|
75
|
|
S-adenosyl-L-methionine binding
|
|
|
|
|
|
|
end case
case <OC:Eukaryota> and <Feature:PS51625:101-102=N-[AST]>
REGION
|
|
101
|
|
102
|
|
S-adenosyl-L-methionine binding
|
|
|
|
|
|
|
end case
case <OC:Eukaryota> and <Feature:PS51625:197=T>
REGION
|
|
197
|
|
199
|
|
S-adenosyl-L-methionine binding
|
|
|
|
|
|
|
end case
case <OC:Bacteria> and <Feature:PS51625:197-200=T-[AEKNRSY]-[FY]-E>
REGION
|
|
197
|
|
200
|
|
Substrate binding
|
|
|
|
|
|
|
end case
case <OC:Bacteria>
BINDING
|
|
49
|
|
49
|
|
S-adenosyl-L-methionine
|
|
|
|
[DE]
|
|
|
end case
case <OC:Eukaryota>
BINDING
|
|
51
|
|
51
|
|
S-adenosyl-L-methionine; via carbonyl oxygen
|
|
|
|
G
|
|
|
end case
case <OC:Bacteria>
BINDING
|
|
74
|
|
74
|
|
S-adenosyl-L-methionine
|
|
|
|
[DE]
|
|
|
BINDING
|
|
101
|
|
101
|
|
S-adenosyl-L-methionine
|
|
|
|
[DEN]
|
|
|
end case
case <OC:Eukaryota>
BINDING
|
|
121
|
|
121
|
|
S-adenosyl-L-methionine; via carbonyl oxygen
|
|
|
|
[CL]
|
|
|
end case
case <OC:Bacteria>
BINDING
|
|
124
|
|
124
|
|
S-adenosyl-L-methionine
|
|
|
|
D
|
|
|
BINDING
|
|
128
|
|
128
|
|
Substrate
|
|
|
|
K
|
|
|
BINDING
|
|
160
|
|
160
|
|
Substrate
|
|
|
|
D
|
|
|
end case
Additional information
[?]
Size range |
unlimited amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q6NU94 (TRMB_XENLA) |
Scope |
Bacteria
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]