PRU00957
General rule information
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Accession | PRU00957 |
Dates | 14-DEC-2011 (Created) 19-NOV-2022 (Last updated, Version 11) |
Data class | Domain |
Predictors | PROSITE; PS51625; SAM_MT_TRMB |
Name | tRNA (guanine-N(7)-)-methyltransferase |
Function | tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) is an enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to tRNA to form tRNA containing N(7)-methylguanine and S-adenosyl-L-homocysteine. |
Propagated annotation
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Description
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+ RecName: EC 2.1.1.33; |
Comments
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Catalytic activity | RHEA:42708: guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine
EC 2.1.1.33 |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. |
Gene Ontology
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GO:0000049; Molecular function: tRNA binding.
GO:0008176; Molecular function: tRNA (guanine-N7-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
GO:0008176; Molecular function: tRNA (guanine-N7-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.
GO:0046500; Biological process: S-adenosylmethionine metabolic process.
Keywords
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case <OC:Eukaryota>
end case
Features
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case <OC:Eukaryota> and <Feature:PS51625:74-75=E-[IL]>
From: PS51625 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 74 | 75 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 |
end case
case <OC:Eukaryota> and <Feature:PS51625:101-102=N-[AST]>
end case
case <OC:Eukaryota> and <Feature:PS51625:197=T>
end case
case <OC:Bacteria> and <Feature:PS51625:197-200=T-[AEKNRSY]-[FY]-E>
end case
case <OC:Bacteria>
end case
case <OC:Eukaryota>
end case
case <OC:Bacteria>
BINDING | 74 | 74 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DE] | ||||||||
BINDING | 101 | 101 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DEN] |
end case
case <OC:Eukaryota>
end case
case <OC:Bacteria>
BINDING | 124 | 124 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | ||||||||
BINDING | 128 | 128 | /ligand="substrate | K | ||||||||
BINDING | 160 | 160 | /ligand="substrate | D |
end case
Additional information
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Size range | unlimited amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q6NU94 (TRMB_XENLA) |
Scope | Bacteria
Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Bacteria [497] Eukaryota [60] All [ 557 ]
- Retrieve set of proteins with 3D structure for this domain