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ProRule PRU00958


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00958
Accession PRU00958
Dates 14-DEC-2011 (Created)
3-SEP-2024 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS51626; SAM_MT_TRM1
Name tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216)
Function tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) is an enzyme that transfers a methyl group from 2 S-adenosyl-L-methionine (SAM) to guanine(26) in tRNA to form N(2)-dimethylguanine(26) in tRNA and 2 S- adenosyl-L-homocysteine.
Scope(s) Archaea
Eukaryota
Bacteria
Aquifex
Example(s) Q9LFU5 (TRM1_ARATH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Eukaryota> and <Length>=425> and <Length<=670>
Protein name + RecName: EC=2.1.1.216;

Comments [?]

CATALYTIC ACTIVITY Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)- dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+); Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Keywords [?]

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

Gene Ontology [?]

case <OCellular component:Eukaryota> and <Length>=425> and <Length<=670>
GO:0160104; Molecular function:tRNA (guanine(26)-N2)-dimethyltransferase activity
end case
GO:0000049; Molecular function:tRNA binding
GO:0008033; Biological process:tRNA processing
GO:0032259; Biological process:methylation

Features [?]

From: PS51626
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Trm1 methyltransferase #"

Additional information [?]

Size range 58-472 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]