PRU00958

Accession	PRU00958
Dates	14-DEC-2011 (Created) 21-NOV-2019 (Last updated, Version 14)

Data class

Domain

Predictors

PROSITE; PS51626; SAM_MT_TRM1

Name	tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216)

Function

tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) is an enzyme that transfers a methyl group from 2 S-adenosyl-L-methionine (SAM) to guanine(26) in tRNA to form N(2)-dimethylguanine(26) in tRNA and 2 S- adenosyl-L-homocysteine.

+ RecName: EC 2.1.1.216;

Catalytic activity

RHEA:43140: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine EC 2.1.1.216

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

GO:0000049; Molecular function: tRNA binding.
GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.

Methyltransferase
RNA-binding
S-adenosyl-L-methionine
Transferase
tRNA processing
tRNA-binding

From: PS51626

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

Trm1 methyltransferase #

Size range	58-472 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q9LFU5 (TRM1_ARATH)
Scope	Archaea Eukaryota Bacteria; Aquifex
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Archaea	[52]
  Bacteria	[1]
  Eukaryota	[15]
  All	[ 68 ]

  
  
• Retrieve set of proteins with 3D structure for this domain