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General rule information [?]

Accession PRU00958
Dates 14-DEC-2011 (Created)
21-NOV-2019 (Last updated, Version 14)
Data class Domain
Predictors PROSITE; PS51626; SAM_MT_TRM1
Name tRNA (guanine(26)-N(2))-dimethyltransferase (EC
Function tRNA (guanine(26)-N(2))-dimethyltransferase (EC is an enzyme that transfers a methyl group from 2 S-adenosyl-L-methionine (SAM) to guanine(26) in tRNA to form N(2)-dimethylguanine(26) in tRNA and 2 S- adenosyl-L-homocysteine.

Propagated annotation [?]

Description [?]

case <OC:Eukaryota> and <Length>=425> and <Length<=670>
+ RecName: EC;

Comments [?]

Catalytic activity RHEA:43140: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
end case

Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Gene Ontology [?]

GO:0000049; Molecular function: tRNA binding.
GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0032259; Biological process: methylation.

Keywords [?]

Features [?]

From: PS51626
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Trm1 methyltransferase #        

Additional information [?]

Size range 58-472 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9LFU5 (TRM1_ARATH)
Bacteria; Aquifex
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]