ProRule PRU00995
General rule information
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| Accession | PRU00995 |
| Dates | 14-JAN-2013 (Created)
19-NOV-2022 (Last updated, Version 24) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50880; TOPRIM |
Name | Toprim domain |
| Function | The Toprim domain is a catalytic domain involved in DNA strand breakage and rejoining. |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | P06786 (TOP2_YEAST); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> and <FTGroup:2> | |
| Protein name | + RecName: EC=5.6.2.2; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).; |
| else case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
Keywords
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| DNA-binding | |
| end case | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| case <FTGroup:2> | |
| GO:0003677; Molecular function:DNA binding | |
Features
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| From: PS50880 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Toprim #" | |||||||||
| BINDING | 7 | 7 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" /ligand_note="catalytic" |
E | 1 | |||||||
| BINDING | 65 | 65 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" /ligand_note="catalytic" |
D | 1 | |||||||
| SITE | 38 | 38 | /note="Interaction with DNA" | K | 2 | |||||||
| SITE | 41 | 41 | /note="Interaction with DNA" | N | 2 | |||||||
Additional information
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| Size range | 105-128 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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