General rule information
[?]
Accession |
PRU00995 |
Dates |
14-JAN-2013 (Created) 21-NOV-2019 (Last updated, Version 20) |
Predictors |
PROSITE; PS50880; TOPRIM
|
Function |
The Toprim domain is a catalytic domain involved in DNA strand breakage and rejoining. |
Propagated annotation
[?]
case <FTGroup:1> and <FTGroup:2>
Catalytic activity |
Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
Cofactor |
Mg(2+) Mn(2+) Ca(2+) Note: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). |
else case <FTGroup:1>
Cofactor |
Mg(2+) Note: Binds two Mg(2+) per subunit. |
end case
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
case <FTGroup:2>
end case
case <FTGroup:1>
end case
From: PS50880 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Toprim #
|
|
|
|
|
|
|
METAL
|
|
7
|
|
7
|
|
Magnesium 1; catalytic
|
|
|
|
E
|
|
1
|
METAL
|
|
65
|
|
65
|
|
Magnesium 1; catalytic
|
|
|
|
D
|
|
1
|
METAL
|
|
65
|
|
65
|
|
Magnesium 2
|
|
|
|
D
|
|
1
|
METAL
|
|
67
|
|
67
|
|
Magnesium 2
|
|
|
|
D
|
|
1
|
SITE
|
|
38
|
|
38
|
|
Interaction with DNA
|
|
|
|
K
|
|
2
|
SITE
|
|
41
|
|
41
|
|
Interaction with DNA
|
|
|
|
N
|
|
2
|
Additional information
[?]
Size range |
105-128 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P06786 (TOP2_YEAST) |
Scope |
Eukaryota
Bacteria
Archaea
Viruses |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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