ProRule PRU00995

General rule information [?]

Accession PRU00995
Dates 14-JAN-2013 (Created)
19-NOV-2022 (Last updated, Version 24)
Data class Domain;
Predictors PROSITE; PS50880; TOPRIM
Name Toprim domain
Function The Toprim domain is a catalytic domain involved in DNA strand breakage and rejoining.
Scope(s) Eukaryota
Example(s) P06786 (TOP2_YEAST);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTGroup:2>
Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).;
else case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case

Keywords [?]

end case
case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
case <FTGroup:2>
GO:0003677; Molecular function:DNA binding

Features [?]

From: PS50880
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Toprim #"
BINDING 7 7 /ligand="Mg(2+)"
E 1
BINDING 65 65 /ligand="Mg(2+)"
D 1
SITE 38 38 /note="Interaction with DNA" K 2
SITE 41 41 /note="Interaction with DNA" N 2

Additional information [?]

Size range 105-128 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]