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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01002


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01002
General rule information [?]

Accession PRU01002
Dates 28-MAY-2013 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51667; WRC
Name WRC domain
Function The WRC domain contains two distinctive features, namely a putative nuclear localization signal and a zinc-finger motif consisting of the conserved spacing of three Cys and one His residues (C3H motif). It has been suggested that the WRC domain functions in DNA binding.
Scope(s) Eukaryota
Magnoliopsida
Example(s) O81001;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
SUBCELLULAR LOCATIONNucleus.
end case

Keywords [?]

Nucleus
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005634; Cellular component:nucleus

Features [?]

From: PS51667
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="WRC #"
MOTIF 6 16 /note="Bipartite nuclear localization signal" R-C-[KR]-R-T-D-G-K-K-W-R 1
MOTIF 34 41 /note="Bipartite nuclear localization signal" [KR]-[GNS]-[KR]-[GHKNP]-R-[AS]-R-K 1

Additional information [?]

Size range 35-55 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]