ProRule logo

General rule information [?]

Accession PRU01010
Dates 24-MAY-2013 (Created)
16-FEB-2023 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS51674; 4FE4S_WBL
Name 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain
Function Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Ptm The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0046872; Molecular function: metal ion binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.

Keywords [?]

end case

Features [?]

From: PS51674
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       4Fe-4S Wbl-type #        
BINDING     2     2       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     29     29       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     32     32       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     38     38       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1

Additional information [?]

Size range 44-84 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6MX01 (WHB7A_MYCTU)
Bacteria; Actinomycetes
Viruses; Timquatrovirus
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]