General rule information
[?]
Accession |
PRU01010 |
Dates |
24-MAY-2013 (Created) 22-NOV-2019 (Last updated, Version 8) |
Predictors |
PROSITE; PS51674; 4FE4S_WBL
|
Name |
4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain |
Function |
Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster. |
Propagated annotation
[?]
case <FTGroup:1>
Cofactor |
[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit. |
Ptm |
The Fe-S cluster can be nitrosylated by nitric oxide (NO). |
|
Upon Fe-S cluster removal intramolecular disulfide bonds are formed. |
end case
case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0046872; Molecular function: metal ion binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.
end case
From: PS51674 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
4Fe-4S Wbl-type #
|
|
|
|
|
|
|
METAL
|
|
2
|
|
2
|
|
Dinitrosyliron [4Fe-8(NO)]; alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
2
|
|
2
|
|
Iron-sulfur (4Fe-4S); alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
29
|
|
29
|
|
Dinitrosyliron [4Fe-8(NO)]; alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
29
|
|
29
|
|
Iron-sulfur (4Fe-4S); alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
32
|
|
32
|
|
Dinitrosyliron [4Fe-8(NO)]; alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
32
|
|
32
|
|
Iron-sulfur (4Fe-4S); alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
38
|
|
38
|
|
Dinitrosyliron [4Fe-8(NO)]; alternate
|
|
|
|
C
|
|
1
|
METAL
|
|
38
|
|
38
|
|
Iron-sulfur (4Fe-4S); alternate
|
|
|
|
C
|
|
1
|
Additional information
[?]
Size range |
44-84 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q6MX01 (WHB7A_MYCTU) |
Scope |
Bacteria; Actinobacteria
Viruses; Siphoviridae |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]