ProRule PRU01010
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01010 |
| Accession | PRU01010 |
| Dates | 24-MAY-2013 (Created)
16-FEB-2023 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51674; 4FE4S_WBL |
Name | 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain |
| Function | Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster. |
| Scope(s) |
Bacteria Actinomycetes Viruses Timquatrovirus |
| Example(s) | Q6MX01 (WHB7A_MYCTU); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.; |
| PTM | The Fe-S cluster can be nitrosylated by nitric oxide (NO). |
| PTM | Upon Fe-S cluster removal intramolecular disulfide bonds are formed. |
| end case | |
Keywords
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| 4Fe-4S | |
| Disulfide bond | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0035731; Molecular function:dinitrosyl-iron complex binding | |
Features
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| From: PS51674 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="4Fe-4S Wbl-type #" | |||||||||
| BINDING | 2 | 2 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 29 | 29 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 32 | 32 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 38 | 38 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
Additional information
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| Size range | 44-84 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [24] Viruses [1] All [ 25 ]
- Retrieve set of proteins with 3D structure for this domain