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ProRule PRU01010


General rule information [?]

Accession PRU01010
Dates 24-MAY-2013 (Created)
16-FEB-2023 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51674; 4FE4S_WBL
Name 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain
Function Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster.
Scope(s) Bacteria
Actinomycetes
Viruses
Timquatrovirus
Example(s) Q6MX01 (WHB7A_MYCTU);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.;
PTMThe Fe-S cluster can be nitrosylated by nitric oxide (NO).
PTMUpon Fe-S cluster removal intramolecular disulfide bonds are formed.
end case

Keywords [?]

4Fe-4S
Disulfide bond
Iron
Iron-sulfur
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0046872; Molecular function:metal ion binding
GO:0035731; Molecular function:dinitrosyl-iron complex binding

Features [?]

From: PS51674
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="4Fe-4S Wbl-type #"
BINDING 2 2 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C 1
BINDING 29 29 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C 1
BINDING 32 32 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C 1
BINDING 38 38 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C 1

Additional information [?]

Size range 44-84 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]