PROSITE

Accession	PRU01010
Dates	24-MAY-2013 (Created) 22-NOV-2019 (Last updated, Version 8)

Data class

Domain

Predictors

PROSITE; PS51674; 4FE4S_WBL

Name	4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain

Function

Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster.

Cofactor	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Ptm	The Fe-S cluster can be nitrosylated by nitric oxide (NO).
	Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0046872; Molecular function: metal ion binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.

4Fe-4S
Disulfide bond
Iron
Iron-sulfur
Metal-binding

From: PS51674
Key		From		To		Description		Tag		Condition		FTGroup
DOMAIN		from		to		4Fe-4S Wbl-type #
METAL		2		2		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		2		2		Iron-sulfur (4Fe-4S); alternate				C		1
METAL		29		29		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		29		29		Iron-sulfur (4Fe-4S); alternate				C		1
METAL		32		32		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		32		32		Iron-sulfur (4Fe-4S); alternate				C		1
METAL		38		38		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		38		38		Iron-sulfur (4Fe-4S); alternate				C		1

Size range	44-84 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q6MX01 (WHB7A_MYCTU)
Scope	Bacteria; Actinobacteria Viruses; Siphoviridae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Bacteria	[24]
  Viruses	[1]
  All	[ 25 ]

  
  
• Retrieve set of proteins with 3D structure for this domain