We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01010
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01010
General rule information
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| Accession | PRU01010 |
| Dates | 24-MAY-2013 (Created)
16-FEB-2023 (Last updated, Version 14) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51674; 4FE4S_WBL |
Name | 4Fe-4S WhiB-like (Wbl)-type iron-sulfur binding domain |
| Function | Wbl-mediated transcription regulation is dependent upon the presence or absence and state (nitrosylated or non-nitrosylated) of the [4Fe-4S] cluster. |
| Scope(s) |
Bacteria Actinomycetes Viruses Timquatrovirus |
| Example(s) | Q6MX01; |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.; |
| PTM | The Fe-S cluster can be nitrosylated by nitric oxide (NO). |
| PTM | Upon Fe-S cluster removal intramolecular disulfide bonds are formed. |
| end case | |
Keywords
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| 4Fe-4S | |
| Disulfide bond | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0035731; Molecular function:dinitrosyl-iron complex binding | |
Features
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| From: PS51674 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="4Fe-4S Wbl-type #" | |||||||||
| BINDING | 2 | 2 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 29 | 29 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 32 | 32 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 38 | 38 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
Additional information
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| Size range | 44-84 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [24] Viruses [1] All [ 25 ]
- Retrieve set of proteins with 3D structure for this domain