ProRule PRU01025
General rule information
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| Accession | PRU01025 |
| Dates | 26-AUG-2014 (Created)
22-NOV-2019 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51688; ICA |
Name | Intramolecular chaperone auto-processing (ICA) domain |
| Function | The Intramolecular Chaperone Auto-processing (ICA)] domain, also called Intramolecuar Chaperone Domain (ICD) or C-terminal Intramolecular Chaperone Domain (CIMCD), is capable of catalyzing trimerization-dependent auto-proteolysis. The ICA domain contains two absolutely conserved serine and lysine residues. They form a catalytic dyad that mediates cleavage at the serine residue. The ICA domain belongs to peptidase family S74. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | Q9Y2G1 (MYRF_HUMAN); |
Propagated annotation
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Keywords
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| case <FTGroup:1> | |
| Autocatalytic cleavage | |
| end case | |
Features
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| From: PS51688 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S74 #" | |||||||||
| SITE | 1-1 | 1 | /note="Cleavage; by autolysis" | P-S | 1 | |||||||
Additional information
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| Size range | 88-238 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [11] Viruses [15] All [ 26 ]
- Retrieve set of proteins with 3D structure for this domain