ProRule PRU01025

General rule information [?]

Accession PRU01025
Dates 26-AUG-2014 (Created)
22-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51688; ICA
Name Intramolecular chaperone auto-processing (ICA) domain
Function The Intramolecular Chaperone Auto-processing (ICA)] domain, also called Intramolecuar Chaperone Domain (ICD) or C-terminal Intramolecular Chaperone Domain (CIMCD), is capable of catalyzing trimerization-dependent auto-proteolysis. The ICA domain contains two absolutely conserved serine and lysine residues. They form a catalytic dyad that mediates cleavage at the serine residue. The ICA domain belongs to peptidase family S74.
Scope(s) Eukaryota
Example(s) Q9Y2G1 (MYRF_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Autocatalytic cleavage
end case

Features [?]

From: PS51688
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S74 #"
SITE 1-1 1 /note="Cleavage; by autolysis" P-S 1

Additional information [?]

Size range 88-238 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]