We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01027
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01027
General rule information
[?]
| Accession | PRU01027 |
| Dates | 30-OCT-2013 (Created)
22-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51690; ALPHAVIRUS_CP |
Name | Alphavirus core protein (CP) domain |
| Function | The alphavirus CP forms peptidase family S3. |
| Scope(s) |
Viruses Alphavirus |
| Example(s) | P22056; |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.21.90; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|- Ser- bond.; EC=3.4.21.90; |
| end case | |
Keywords
[?]
| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
[?]
| case <FTGroup:1> | |
| GO:0004252; Molecular function:serine-type endopeptidase activity | |
| GO:0006508; Biological process:proteolysis | |
Features
[?]
| From: PS51690 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S3 #" | |||||||||
| ACT_SITE | 27 | 27 | /note="Charge relay system" | H | 1 | |||||||
| ACT_SITE | 49 | 49 | /note="Charge relay system" | D | 1 | |||||||
| ACT_SITE | 101 | 101 | /note="Charge relay system" | S | 1 | |||||||
Additional information
[?]
| Size range | 139-161 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Viruses [35] All [ 35 ]
- Retrieve set of proteins with 3D structure for this domain