Home  |  Contact
annotation rule: PRU01031

General rule information [?]

Accession PRU01031
Dates 21-AUG-2014 (Created)
14-MAY-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51694; PEPTIDASE_M66
Name Peptidase family M66 domain
Function The peptidase family M66 domain is a zinc metalloprotease.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 3.4.24.-;
end case


Comments [?]

case <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case


Gene Ontology [?]

case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case

case <FTGroup:1>
GO:0006508; Biological process: proteolysis.
GO:0004222; Molecular function: metalloendopeptidase activity.
end case


Keywords [?]

case <FTGroup:1>
Hydrolase
Metalloprotease
Protease
end case

case <FTGroup:2>
Metal-binding
Zinc
end case


Features [?]

From: PS51694
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase M66        
ACT_SITE     154     154             E   1
BINDING     153     153       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1,2
BINDING     157     157       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1,2
BINDING     163     163       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1,2

Additional information [?]

Size range 245-282 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O82882 (STCE_ECO57)
Scope
Bacteria; Proteobacteria
Eukaryota; Dictyostelium
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View rule in raw text format (no links)


UniProtKB rule member sequences [?]