ProRule PRU01031
General rule information
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Accession | PRU01031 |
Dates | 21-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 8) |
Data class | Domain; |
Predictors |
PROSITE; PS51694; PEPTIDASE_M66 |
Name | Peptidase family M66 domain |
Function | The peptidase family M66 domain is a zinc metalloprotease. |
Scope(s) |
Bacteria Pseudomonadota Eukaryota Dictyostelium |
Example(s) | O82882 (STCE_ECO57); |
Propagated annotation
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Identifier, protein and gene names
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case <FTGroup:1> | |
Protein name | + RecName: EC=3.4.24.-; |
end case |
Comments
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case <FTGroup:2> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
end case |
Keywords
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case <FTGroup:1> | |
Hydrolase | |
Metalloprotease | |
Protease | |
end case | |
case <FTGroup:2> | |
Metal-binding | |
Zinc | |
end case |
Gene Ontology
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case <FTGroup:2> | |
GO:0046872; Molecular function:metal ion binding | |
end case | |
case <FTGroup:1> | |
GO:0006508; Biological process:proteolysis | |
GO:0004222; Molecular function:metalloendopeptidase activity | |
end case |
Features
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From: PS51694 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase M66" | |||||||||
ACT_SITE | 154 | 154 | E | 1 | ||||||||
BINDING | 153 | 153 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
BINDING | 153 | 153 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 2 | |||||||
BINDING | 157 | 157 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 |
Additional information
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Size range | 245-282 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [12] Eukaryota [5] All [ 17 ]
- Retrieve set of proteins with 3D structure for this domain