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ProRule PRU01031


General rule information [?]

Accession PRU01031
Dates 21-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51694; PEPTIDASE_M66
Name Peptidase family M66 domain
Function The peptidase family M66 domain is a zinc metalloprotease.
Scope(s) Bacteria
Pseudomonadota
Eukaryota
Dictyostelium
Example(s) O82882 (STCE_ECO57);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.24.-;
end case

Comments [?]

case <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case

Keywords [?]

case <FTGroup:1>
Hydrolase
Metalloprotease
Protease
end case
case <FTGroup:2>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
end case
case <FTGroup:1>
GO:0006508; Biological process:proteolysis
GO:0004222; Molecular function:metalloendopeptidase activity
end case

Features [?]

From: PS51694
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M66"
ACT_SITE 154 154 E 1
BINDING 153 153 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
BINDING 153 153 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 2
BINDING 157 157 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1

Additional information [?]

Size range 245-282 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]