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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01031


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01031
General rule information [?]

Accession PRU01031
Dates 21-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51694; PEPTIDASE_M66
Name Peptidase family M66 domain
Function The peptidase family M66 domain is a zinc metalloprotease.
Scope(s) Bacteria
Pseudomonadota
Eukaryota
Dictyostelium
Example(s) O82882;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.24.-;
end case

Comments [?]

case <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case

Keywords [?]

case <FTGroup:1>
Hydrolase
Metalloprotease
Protease
end case
case <FTGroup:2>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
end case
case <FTGroup:1>
GO:0006508; Biological process:proteolysis
GO:0004222; Molecular function:metalloendopeptidase activity
end case

Features [?]

From: PS51694
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M66"
ACT_SITE 154 154 E 1
BINDING 153 153 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
BINDING 153 153 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 2
BINDING 157 157 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1

Additional information [?]

Size range 245-282 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]