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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01036


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01036
General rule information [?]

Accession PRU01036
Dates 22-AUG-2014 (Created)
30-SEP-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51699; SEA_DG
Name DG-type SEA domain
Function The DG-type SEA domain forms the peptidase S72 family.
Scope(s) Eukaryota
Eutheria
Example(s) Q62165;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
PTMAutolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological conditions, shedding of beta-dystroglcan can occur releasing a peptide of about 30 kDa.
end case

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0016011; Cellular component:dystroglycan complex

Features [?]

From: PS51699
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S72 #"
SITE 53 54 /note="Cleavage; by autolysis" G-S 1

Additional information [?]

Size range 100-120 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]