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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01037


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01037
General rule information [?]

Accession PRU01037
Dates 22-AUG-2014 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51700; SEPARIN
Name SEPARIN core domain
Function The separin core domain contains a conserved histidine and cyteine residue, which are hallmarks of cysteine proteases. The separin core domain forms the peptidase C50 family.
Scope(s) Eukaryota
Example(s) Q14674;

Propagated annotation [?]

Keywords [?]

case <FTTag:protease>
Hydrolase
Protease
Thiol protease
end case

Features [?]

From: PS51700
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C50 #"
ACT_SITE 85 85 protease C

Additional information [?]

Size range 85-110 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]