PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01046


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01046
General rule information [?]

Accession PRU01046
Dates 28-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51709; G_TRME
Name TrmE-type guanine nucleotide-binding (G) domain
Function TrmE (also called MnmE) contains a canonical G domain and is conserved in all three kingdoms of life.case
Scope(s) Bacteria
Eukaryota
Example(s) P25522;

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case

Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
end case
case <FTGroup:3>
Potassium
end case
case <FTGroup:2> or <FTGroup:3>
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0000287; Molecular function:magnesium ion binding
end case
case <FTGroup:3>
GO:0030955; Molecular function:potassium ion binding
end case
case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS51709
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TrmE-type G #"
BINDING 8 15 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 G-x(4)-G-K-[ST] 1
BINDING 34 38 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 x(2)-[ST]-x(2) 1
BINDING 55 58 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 D-x(2)-G 1
BINDING 115 118 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [NT]-K-x-D 1
BINDING 139 141 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 1
BINDING 15 15 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 36 36 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 11 11 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 N 3
BINDING 30 30 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ST] 3
BINDING 32 32 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ILV] 3
BINDING 35 35 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ST] 3

Additional information [?]

Size range 128-277 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]