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annotation rule: PRU01046

General rule information [?]

Accession PRU01046
Dates 28-MAR-2014 (Created)
22-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51709; G_TRME
Name TrmE-type guanine nucleotide-binding (G) domain
Function TrmE (also called MnmE) contains a canonical G domain and is conserved in all three kingdoms of life.

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
Cofactor Mg(2+)
end case

case <FTGroup:3>
Cofactor K(+)
Note: Binds 1 potassium ion per subunit.
end case

Similarity Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
end case

case <FTGroup:2>
GO:0000287; Molecular function: magnesium ion binding.
end case

case <FTGroup:3>
GO:0030955; Molecular function: potassium ion binding.
end case

case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
end case

Keywords [?]

case <FTGroup:1>
end case

case <FTGroup:2>
end case

case <FTGroup:3>
end case

case <FTGroup:2> or <FTGroup:3>
end case

Features [?]

From: PS51709
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       TrmE-type G #        
NP_BIND     8     15       GTP     G-x(4)-G-K-[ST]   1
NP_BIND     34     38       GTP     x(2)-[ST]-x(2)   1
NP_BIND     55     58       GTP     D-x(2)-G   1
NP_BIND     115     118       GTP     [NT]-K-x-D   1
NP_BIND     139     141       GTP         1
METAL     15     15       Magnesium     [ST]   2
METAL     36     36       Magnesium     [ST]   2
METAL     11     11       Potassium     N   3
METAL     30     30       Potassium; via carbonyl oxygen     [ST]   3
METAL     32     32       Potassium; via carbonyl oxygen     [ILV]   3
METAL     35     35       Potassium     [ST]   3

Additional information [?]

Size range 128-277 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P25522 (MNME_ECOLI)
Comments None


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UniProtKB rule member sequences [?]