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ProRule PRU01046


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PURL: https://purl.expasy.org/prosite/rule/PRU01046
General rule information [?]

Accession PRU01046
Dates 28-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51709; G_TRME
Name TrmE-type guanine nucleotide-binding (G) domain
Function TrmE (also called MnmE) contains a canonical G domain and is conserved in all three kingdoms of life.case
Scope(s) Bacteria
Eukaryota
Example(s) P25522 (MNME_ECOLI);

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case

Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
end case
case <FTGroup:3>
Potassium
end case
case <FTGroup:2> or <FTGroup:3>
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0000287; Molecular function:magnesium ion binding
end case
case <FTGroup:3>
GO:0030955; Molecular function:potassium ion binding
end case
case <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS51709
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TrmE-type G #"
BINDING 8 15 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 G-x(4)-G-K-[ST] 1
BINDING 34 38 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 x(2)-[ST]-x(2) 1
BINDING 55 58 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 D-x(2)-G 1
BINDING 115 118 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [NT]-K-x-D 1
BINDING 139 141 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 1
BINDING 15 15 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 36 36 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 11 11 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 N 3
BINDING 30 30 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ST] 3
BINDING 32 32 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ILV] 3
BINDING 35 35 /ligand="K(+)"
/ligand_id="ChEBI:CHEBI:29103"		 [ST] 3

Additional information [?]

Size range 128-277 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]