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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01048


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PURL: https://purl.expasy.org/prosite/rule/PRU01048
General rule information [?]

Accession PRU01048
Dates 01-APR-2014 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51711; G_FEOB
Name FeoB-type guanine nucleotide-binding (G) domain
Function FeoB is involved in the uptake of ferrous iron (Fe(2+)), an important cofactor in biological electron transfer and catalysis.
Scope(s) Bacteria
Archaea
Methanocaldococcus
Example(s) P33650;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.

Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
GO:0000287; Molecular function:magnesium ion binding
end case

Features [?]

From: PS51711
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="FeoB-type G #"
BINDING 8 15 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#"		 G-x(4)-G-K-[ST] 1
BINDING 33 37 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#"		 x(2)-[ST]-x(2) 1
BINDING 54 57 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#"		 D-x(2)-G 1
BINDING 114 117 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 N-x(2)-D 1
BINDING 143 145 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 1
BINDING 15 15 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 35 35 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2

Additional information [?]

Size range 151-177 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]