We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01051
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01051
General rule information
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| Accession | PRU01051 |
| Dates | 20-MAY-2020 (Created)
20-MAY-2020 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51714; G_BMS1 |
Name | Bms1-type guanine nucleotide-binding (G) domain |
| Function | Bms1p and Tsr1p represent a new family of factors required for ribosome biogenesis. They are each independently required for 40S ribosomal subunit biogenesis. Bms1p, a protein required for pre-rRNA processing, contains an evolutionarily conserved G domain with five conserved polypeptide loops designated G1 through G5, which form contact sites with the guanine nucleotide or coordinate the Mg(2+) ion. Tsr1p lacks a P-loop and is not predicted to bind GTP. |
| Scope(s) |
Eukaryota |
| Example(s) | Q07381; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. |
Keywords
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| GTP-binding | |
| Nucleotide-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0005525; Molecular function:GTP binding | |
Features
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| From: PS51714 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Bms1-type G #" | |||||||||
| REGION | 10 | 17 | /note="G1 #" | G-x(4)-G-K-[ST] | 1 | |||||||
| REGION | 42 | 46 | /note="G2 #" | x(2)-T-x(2) | 1 | |||||||
| REGION | 57 | 60 | /note="G3 #" | E-x(3) | 1 | |||||||
| REGION | 110 | 113 | /note="G4 #" | T-H-x-D | 1 | |||||||
| REGION | 144 | 146 | /note="G5 #" | 1 | ||||||||
Additional information
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| Size range | 157-195 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [13] All [ 13 ]
- Retrieve set of proteins with 3D structure for this domain