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annotation rule: PRU01053

General rule information [?]

Accession PRU01053
Dates 11-MAY-2020 (Created)
11-MAY-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51716; G_IRG
Name IRG-type guanine nucleotide-binding (G) domain
Function The p47 or immunity-related GTPases (IRG) are at least as old as the vertebrates. The IRG proteins are an essential resistance system in the mouse for immunity against pathogens that enter the cell via a vacuole. Despite its importance for the mouse, the IRG resistance system is absent from humans because it has been lost during the divergent evolution of the primates. The IRG proteins appear to be accompanied phylogenetically by homologous proteins, named 'quasi IRG' (IRGQ) proteins, that probably lack nucleotide binding or hydrolysis function, and that may form regulatory heterodimers with functional IRG proteins.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

Gene Ontology [?]

case <Feature:PS51716:9-16=G-x(4)-G-[KM]-S> and <Feature:PS51716:59-62=D-x(2)-G> and <Feature:PS51716:116-119=[NT]-x-x-D>
GO:0005525; Molecular function: GTP binding.

Keywords [?]

end case


Features [?]

From: PS51716
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       IRG-type G #        

Additional information [?]

Size range 140-237 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6AYC2 (IRGM_RAT)
Scope
Eukaryota; Eutheria
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]