We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01053
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01053
General rule information
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| Accession | PRU01053 |
| Dates | 11-MAY-2020 (Created)
11-MAY-2020 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51716; G_IRG |
Name | IRG-type guanine nucleotide-binding (G) domain |
| Function | The p47 or immunity-related GTPases (IRG) are at least as old as the vertebrates. The IRG proteins are an essential resistance system in the mouse for immunity against pathogens that enter the cell via a vacuole. Despite its importance for the mouse, the IRG resistance system is absent from humans because it has been lost during the divergent evolution of the primates. The IRG proteins appear to be accompanied phylogenetically by homologous proteins, named 'quasi IRG' (IRGQ) proteins, that probably lack nucleotide binding or hydrolysis function, and that may form regulatory heterodimers with functional IRG proteins. |
| Scope(s) |
Eukaryota Eutheria |
| Example(s) | Q6AYC2; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. |
Keywords
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| GTP-binding | |
| Hydrolase | |
| Nucleotide-binding | |
| end case | |
Gene Ontology
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| case <Feature:PS51716:9-16=G-x(4)-G-[KM]-S> and <Feature:PS51716:59-62=D-x(2)-G> and <Feature:PS51716:116-119=[NT]-x-x-D> | |
| GO:0005525; Molecular function:GTP binding | |
Features
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| From: PS51716 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="IRG-type G #" | |||||||||
Additional information
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| Size range | 140-237 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [15] All [ 15 ]
- Retrieve set of proteins with 3D structure for this domain