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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01070


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PURL: https://purl.expasy.org/prosite/rule/PRU01070
General rule information [?]

Accession PRU01070
Dates 14-OCT-2014 (Created)
22-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors
case c? <OC:Bacteria>
PROSITE; PS00409; PROKAR_NTER_METHYL
end case
Name Prokaryotic N-terminal methylation
Function Gram-negative bacteria produce pilin which are characterized by the presence of a very short leader peptide of 6 to 7 residues, followed by a methylated N-terminal phenylalanine residue and by a highly conserved sequence of about 24 hydrophobic residues. This class of pilin is often referred to as NMePhe or type-4 pili.
Scope(s) Bacteria
Example(s) P02975;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name Flags: Precursor;

Features [?]

From: PS00409
Key From To Description Tag Condition FTGroup
PROPEP Nter 2
CHAIN 3 Cter /note=""
MOD_RES 3 3 /note="N-methylphenylalanine" F
MOD_RES 3 3 /note="N-methyltyrosine" Y
MOD_RES 3 3 /note="N-methylleucine" L
MOD_RES 3 3 /note="N-methylisoleucine" I
MOD_RES 3 3 /note="N-methylmethionine" M

Additional information [?]

Size range 11-31 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]